scholarly journals A role for docosahexaenoic acid-derived neuroprotectin D1 in neural cell survival and Alzheimer disease

2005 ◽  
Vol 115 (10) ◽  
pp. 2774-2783 ◽  
Author(s):  
W. J. Lukiw
Keyword(s):  
Alzheimer Disease ◽  
Docosahexaenoic Acid ◽  
Cell Survival ◽  
Neural Cell ◽  
Neuroprotectin D1

scholarly journals Docosahexaenoic Acid-Derived Neuroprotectin D1 Induces Neuronal Survival via Secretase- and PPARγ-Mediated Mechanisms in Alzheimer's Disease Models

PLoS ONE ◽  
2011 ◽  
Vol 6 (1) ◽  
pp. e15816 ◽  
Author(s):  
Yuhai Zhao ◽  
Frederic Calon ◽  
Carl Julien ◽  
Jeremy W. Winkler ◽  
Nicos A. Petasis ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Docosahexaenoic Acid ◽  
Neuronal Survival ◽  
Disease Models ◽  
Neuroprotectin D1

scholarly journals Neurogenesis and Increase in Differentiated Neural Cell Survival via Phosphorylation of Akt1 after Fluoxetine Treatment of Stem Cells

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Anahita Rahmani ◽  
Danial Kheradmand ◽  
Peyman Keyhanvar ◽  
Alireza Shoae-Hassani ◽  
Amir Darbandi-Azar
Keyword(s):  
Survival Rate ◽  
Cell Survival ◽  
Neural Cell ◽  
Neural Cells ◽  
Chain Reaction ◽  
Serine Threonine Kinase ◽  
Threonine Kinase ◽  
Fluoxetine Treatment ◽  
Polymerase Chain

Fluoxetine (FLX) is a selective serotonin reuptake inhibitor (SSRI). Its action is possibly through an increase in neural cell survival. The mechanism of improved survival rate of neurons by FLX may relate to the overexpression of some kinases such as Akt protein. Akt1 (a serine/threonine kinase) plays a key role in the modulation of cell proliferation and survival. Our study evaluated the effects of FLX on mesenchymal stem cell (MSC) fate and Akt1 phosphorylation levels in MSCs. Evaluation tests included reverse transcriptase polymerase chain reaction, western blot, and immunocytochemistry assays. Nestin, MAP-2, andβ-tubulin were detected after neurogenesis as neural markers. TenμM of FLX upregulated phosphorylation of Akt1 protein in induced hEnSC significantly. Also FLX did increase viability of these MSCs. Continuous FLX treatment after neurogenesis elevated the survival rate of differentiated neural cells probably by enhanced induction of Akt1 phosphorylation. This study addresses a novel role of FLX in neurogenesis and differentiated neural cell survival that may contribute to explaining the therapeutic action of fluoxetine in regenerative pharmacology.

Spleen Cell Survival and Proliferation Are Differentially Altered by Docosahexaenoic Acid

1997 ◽  
Vol 180 (2) ◽  
pp. 153-161 ◽  
Author(s):  
John M. Scherer ◽  
William Stillwell ◽  
Laura J. Jenski
Keyword(s):  
Docosahexaenoic Acid ◽  
Cell Survival ◽  
Spleen Cell ◽  
Cell Survival And Proliferation

scholarly journals Association of Docosahexaenoic Acid Supplementation With Alzheimer Disease Stage in Apolipoprotein E ε4 Carriers

2017 ◽  
Vol 74 (3) ◽  
pp. 339 ◽  
Author(s):  
Hussein N. Yassine ◽  
Meredith N. Braskie ◽  
Wendy J. Mack ◽  
Katherine J. Castor ◽  
Alfred N. Fonteh ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Docosahexaenoic Acid ◽  
Apolipoprotein E ◽  
Disease Stage ◽  
Acid Supplementation
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