scholarly journals The crucial role of Campylobacter jejuni genes in anti-ganglioside antibody induction in Guillain-Barré syndrome

2004 ◽  
Vol 114 (11) ◽  
pp. 1659-1665 ◽  
Author(s):  
Peggy C.R. Godschalk ◽  
Astrid P. Heikema ◽  
Michel Gilbert ◽  
Tomoko Komagamine ◽  
C. Wim Ang ◽  
...  
Keyword(s):  
Campylobacter Jejuni ◽  
Crucial Role ◽  
Guillain Barre Syndrome ◽  
Guillain Barré Syndrome ◽  
Antibody Induction ◽  
Guillain Barré

Increased incidence of Campylobacter jejuni-associated Guillain–Barré syndromes in the Greater Paris area

2013 ◽  
Vol 142 (8) ◽  
pp. 1609-1613 ◽  
Author(s):  
V. SIVADON-TARDY ◽  
R. PORCHER ◽  
D. ORLIKOWSKI ◽  
E. RONCO ◽  
E. GAULT ◽  
...  
Keyword(s):  
Campylobacter Jejuni ◽  
Guillain Barre Syndrome ◽  
Annual Increment ◽  
Paris Area ◽  
Guillain Barré Syndrome ◽  
Paris Region ◽  
Guillain Barré ◽  
Mean Annual Increment

SUMMARYThe role of Campylobacter jejuni as the triggering agent of Guillain–Barré syndrome (GBS) has not been reassessed since the end of the 1990s in France. We report that the number of C. jejuni-related GBS cases increased continuously between 1996 and 2007 in the Paris region (mean annual increment: 7%, P = 0·007).

scholarly journals Antibodies to ganglioside GM1 and Campylobacter jejuni in patients with Guillain-Barre syndrome

2005 ◽  
Vol 133 (3-4) ◽  
pp. 123-128 ◽  
Author(s):  
Ivana Basta ◽  
Ljubica Suturkova ◽  
Ana Vujic ◽  
Stojanka Aleksic ◽  
Ana Poceva ◽  
...  
Keyword(s):  
Campylobacter Jejuni ◽  
High Titer ◽  
Guillain Barre Syndrome ◽  
Motor Neuropathy ◽  
Serum Antibodies ◽  
Guillain Barré Syndrome ◽  
Flagellar Protein ◽  
Antecedent Infection ◽  
Guillain Barré

Guillain-Barre syndrome (GBS) is an acute immune mediated neuropathy, polyradiculoneuritis, characterized by rapid onset of symmetric extremity muscle paralysis, areflexia and albuminocytological dissociation in the cerebrospinal fluid (CSF). Recently, the heterogeneity of GBS has been noticed with definition of several GBS variants. The axonal GBS associated with anti-GM1 antibodies is the most important variant with the specific role of Campylobacter jejuni (CJ) in the induction of the disease. The role of our study was to determine the frequency of antecedent infection with CJ in the population of our patients with GBS, the association with anti-GM1 antibodies and the distribution of these antibodies within clinical forms of the disease. The diagnosis of GBS has been established in 17 patients according to clinical, electrophysiological and laboratory (CSF) criteria. The serum antibodies to 63 kDa flagellar protein isolated from CJ serotype 0:19 were determined by ELISA and Western blot and serum anti-GM1 antibodies by ELISA. In relation to the disability score two patients were ambulatory, five were ambulatory with support, seven were bedridden and two patients needed respirator. Five (29%) patients had pure motor, while 12 (71%) had sensorimotor GBS. The crania! nerves were involved in 11 (65%) and 9 (53%) patients had autonomic dysfunction. Electromyoneurography showed primary axonal, predominantly motor neuropathy in 6 (35%) and demyelinating sensorimotor neuropathy in 11 (65%) patients. The CSF protein content ranged from 0.47 to 3.88 g/L. The antecedent infection with CJ was shown by serum antibodies to CJ flagellar protein in 12 (71%) patients. Fifteen (88%) patients had IgG anti-GMI antibodies. Twelve (71%) patients had both antibodies. In relation to the clinical form, anti-CJ antibodies were found in 8 (73%) out of 11 patients with demyelinating GBS and in 4 (66.6%) out of b patients with axonal GBS. The high titer of anti-GM1 antibodies was found in all patients (100%) with axonal and in 9 (82%) out of 11 patients with demyelinating GBS. The association of IgG anti-CJ and IgG anti-GM1 antibodies was found in 4 (66.6%) out of b patients with axonal and in 8 (73%) out of 11 patients with demyelinating GBS. The main features of our patients with GBS were high frequency of antecedent infection with CJ, unusually frequent association with anti-GM1 antibodies, and equally frequent association of anti CJ and anti-GM1 antibodies in both, axonal and demyelinating GBS.

Role of Gancyclovir and HAART Administration in the Treatment of a Rare Complication of HIV Disease: Cytomegalovirus-Associated Guillain-Barré Syndrome

2001 ◽  
Vol 13 (5) ◽  
pp. 575-577 ◽  
Author(s):  
L. Calza ◽  
R. Manfredi ◽  
G. Marinacci ◽  
E. Briganti ◽  
R. Giuliani S. Talo' ◽  
...  
Keyword(s):  
Rare Complication ◽  
Guillain Barre Syndrome ◽  
Hiv Disease ◽  
Guillain Barré Syndrome ◽  
Guillain Barré
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