scholarly journals Myc confers androgen-independent prostate cancer cell growth

2003 ◽  
Vol 112 (11) ◽  
pp. 1724-1731 ◽  
Author(s):  
David Bernard ◽  
Albin Pourtier-Manzanedo ◽  
Jesús Gil ◽  
David H. Beach
Keyword(s):  
Prostate Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Cancer Cell Growth ◽  
Androgen Independent

scholarly journals Evidence that androgen-independent stromal growth factor signals promote androgen-insensitive prostate cancer cell growth in vivo

2009 ◽  
Vol 16 (2) ◽  
pp. 415-428 ◽  
Author(s):  
Kenichiro Ishii ◽  
Tetsuya Imamura ◽  
Kazuhiro Iguchi ◽  
Shigeki Arase ◽  
Yuko Yoshio ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Growth Factor ◽  
Cell Growth ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Receptor Expression ◽  
Urogenital Sinus ◽  
Cancer Cell Growth ◽  
Androgen Ablation ◽  
Androgen Independent

Activation of tumor–stromal interactions is considered to play a critical role in the promotion of tumorigenesis. To discover new therapeutic targets for hormone-refractory prostate tumor growth under androgen ablation therapy, androgen-sensitive LNCaP cells and the derived sublines, E9 (androgen-low-sensitive), and AIDL (androgen-insensitive), were recombined with androgen-dependent embryonic rat urogenital sinus mesenchyme (UGM). Tumors of E9+UGM and AIDL+UGM were approximately three times as large as those of LNCaP+UGM. Tumors grown in castrated hosts exhibited reduced growth as compared with those in intact hosts. However, in castrated hosts, E9+UGM and AIDL+UGM tumors were still approximately twice as large as those of LNCaP+UGM. Cell proliferation in tumors of E9+UGM and AIDL+UGM grown in castrated host, was significantly higher than that in tumors of LNCaP+UGM. In vitro, expression of fibroblast growth factor (FGF)-2 and IGF-I, but not FGF-7 mRNA, was significantly reduced in UGM under androgen starvation. In cell culture, E9 cells were responsive to FGF-2 and FGF-7 stimulation, while AIDL responded to FGF-7 and IGF-1. Expression of FGFR1 and FGFR2 was considerably higher in E9 than those in LNCaP, similarly expression of FGFR2 and IGF-IR were elevated in AIDL. These data suggest that activation of prostate cancer cell growth through growth factor receptor expression may result in the activity of otherwise androgen-independent stromal growth factor signals such as FGF-7 under conditions of androgen ablation.

Phosphoproteome analysis demonstrates the potential role of THRAP3 phosphorylation in androgen-independent prostate cancer cell growth

PROTEOMICS ◽  
2016 ◽  
Vol 16 (7) ◽  
pp. 1069-1078 ◽  
Author(s):  
Yoko Ino ◽  
Noriaki Arakawa ◽  
Hitoshi Ishiguro ◽  
Hiroji Uemura ◽  
Yoshinobu Kubota ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Potential Role ◽  
Prostate Cancer Cell ◽  
Cancer Cell Growth ◽  
Androgen Independent

scholarly journals Protocadherin-PC promotes androgen-independent prostate cancer cell growth

The Prostate ◽  
2006 ◽  
Vol 66 (10) ◽  
pp. 1100-1113 ◽  
Author(s):  
Stephane Terry ◽  
Luis Queires ◽  
Sixtina Gil-Diez-de-Medina ◽  
Min-Wei Chen ◽  
Alexandre de la Taille ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Cancer Cell Growth ◽  
Androgen Independent

935 Activation of HIF1α promotes androgen independent prostate cancer cell growth

2013 ◽  
Vol 12 (1) ◽  
pp. e935
Author(s):  
M. Tran ◽  
F. Lo ◽  
A. Ramos-Montoya ◽  
H. Scott ◽  
S. Menon ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Cancer Cell Growth ◽  
Androgen Independent

scholarly journals SUMOylation of TBL1 and TBLR1 promotes androgen-independent prostate cancer cell growth

Oncotarget ◽  
2016 ◽  
Vol 7 (27) ◽  
pp. 41110-41122 ◽  
Author(s):  
Soo-Yeon Park ◽  
Younghwa Na ◽  
Mee-Hee Lee ◽  
Jae-Sung Seo ◽  
Yoo-Hyun Lee ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Cancer Cell Growth ◽  
Androgen Independent

794: Valproic Acid Inhibits Prostate Cancer Cell Growth in Vitro and in Vivo

2006 ◽  
Vol 175 (4S) ◽  
pp. 257-257
Author(s):  
Jennifer Sung ◽  
Qinghua Xia ◽  
Wasim Chowdhury ◽  
Shabana Shabbeer ◽  
Michael Carducci ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Valproic Acid ◽  
Cell Growth ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Cancer Cell Growth
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