scholarly journals Induction of CD4+ T cell–dependent antitumor immunity by TAT-mediated tumor antigen delivery into dendritic cells

2002 ◽  
Vol 109 (11) ◽  
pp. 1463-1470 ◽  
Author(s):  
Helen Y. Wang ◽  
Tihui Fu ◽  
Gang Wang ◽  
Gang Zeng ◽  
Donna M. Perry-Lalley ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
Tumor Antigen ◽  
Antitumor Immunity ◽  
Cd4 T Cell ◽  
Antigen Delivery

scholarly journals A novel CD4 T-cell epitope described from one of the cervical cancer patients vaccinated with HPV 16 or 18 E7-pulsed dendritic cells

2008 ◽  
Vol 58 (2) ◽  
pp. 309-309
Author(s):  
Xuelian Wang ◽  
Alessandro D. Santin ◽  
Stefania Bellone ◽  
Sushil Gupta ◽  
Mayumi Nakagawa
Keyword(s):  
Cervical Cancer ◽  
Dendritic Cells ◽  
T Cell ◽  
Cancer Patients ◽  
Cell Epitope ◽  
Cd4 T Cell ◽  
T Cell Epitope ◽  
Hpv 16

scholarly journals B-cell follicle development remodels the conduit system and allows soluble antigen delivery to follicular dendritic cells

Blood ◽  
2009 ◽  
Vol 114 (24) ◽  
pp. 4989-4997 ◽  
Author(s):  
Marc Bajénoff ◽  
Ronald N. Germain
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
B Cell ◽  
Soluble Antigen ◽  
Antigen Delivery ◽  
Follicular Dendritic Cells ◽  
Conduit System ◽  
Follicular Dendritic ◽  
Conduit Network ◽  
Cell Zone

Abstract Afferent lymph is transported throughout lymph nodes (LNs) by the conduit system. Whereas this conduit network is dense in the T-cell zone, it is sparse in B-cell follicles. In this study, we show that this differential organization emerges during lymph node development. Neonatal LNs lack B follicles, but have a developed T-cell zone and a dense conduit network. As new T and B cells enter the developing LN, the conduit network density is maintained in the T, but not the B zone, leading to a profound remodeling of the follicular network that nevertheless maintains its connectivity. In adults, the residual follicular conduits transport soluble antigen to deep regions, where follicular dendritic cells are abundant and appear to replace the fibroblastic reticular cells that enwrap conduits in the T zone. This strategic location correlates with the capacity of the follicular dendritic cells to capture antigen even in the absence of antigen-specific antibodies. Together, these results describe how the stromal organization of the T and B regions of LNs diverges during development, giving rise to distinct antigen transport and delivery modes in the 2 compartments.

RNF2 ablation reprograms the tumor-immune microenvironment and stimulates durable NK and CD4+ T-cell-dependent antitumor immunity

Nature Cancer ◽  
2021 ◽  
Vol 2 (10) ◽  
pp. 1018-1038
Author(s):  
Zhuo Zhang ◽  
Lin Luo ◽  
Chuan Xing ◽  
Yu Chen ◽  
Peng Xu ◽  
...  
Keyword(s):  
T Cell ◽  
Antitumor Immunity ◽  
Cd4 T Cell ◽  
Immune Microenvironment ◽  
Tumor Immune Microenvironment
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