scholarly journals Antigen-specific CD4+ T cells drive airway smooth muscle remodeling in experimental asthma

2005 ◽  
Vol 115 (6) ◽  
pp. 1580-1589 ◽  
Author(s):  
David Ramos-Barbón ◽  
John F. Presley ◽  
Qutayba A. Hamid ◽  
Elizabeth D. Fixman ◽  
James G. Martin
Keyword(s):  
T Cells ◽  
Smooth Muscle ◽  
Airway Smooth Muscle ◽  
Cd4 T Cells ◽  
Muscle Remodeling

scholarly journals CD4+T cells enhance the unloaded shortening velocity of airway smooth muscle by altering the contractile protein expression

2014 ◽  
Vol 592 (14) ◽  
pp. 2999-3012 ◽  
Author(s):  
Oleg S. Matusovsky ◽  
Emily M. Nakada ◽  
Linda Kachmar ◽  
Elizabeth D. Fixman ◽  
Anne-Marie Lauzon
Keyword(s):  
T Cells ◽  
Smooth Muscle ◽  
Protein Expression ◽  
Airway Smooth Muscle ◽  
Cd4 T Cells ◽  
Contractile Protein ◽  
Shortening Velocity

scholarly journals Nanotubes Connect CD4+T Cells to Airway Smooth Muscle Cells: Novel Mechanism of T Cell Survival

2015 ◽  
Vol 194 (12) ◽  
pp. 5626-5634 ◽  
Author(s):  
Saba Al Heialy ◽  
Melissa Zeroual ◽  
Soroor Farahnak ◽  
Toby McGovern ◽  
Paul-André Risse ◽  
...  
Keyword(s):  
T Cells ◽  
Smooth Muscle ◽  
T Cell ◽  
Smooth Muscle Cells ◽  
Cell Survival ◽  
Airway Smooth Muscle ◽  
Cd4 T Cells ◽  
Muscle Cells ◽  
Airway Smooth Muscle Cells ◽  
T Cell Survival

scholarly journals Contact between Cd4+ T Cells and Smooth Muscle Tissue Enhances Contractile Function

2013 ◽  
Vol 104 (2) ◽  
pp. 452a-453a
Author(s):  
Oleg S. Matusovsky ◽  
Emily M. Nakada ◽  
Linda Kachmar ◽  
Elizabeth Fixman ◽  
Anne-Marie Lauzon
Keyword(s):  
T Cells ◽  
Smooth Muscle ◽  
Muscle Tissue ◽  
Cd4 T Cells ◽  
Contractile Function ◽  
Smooth Muscle Tissue

Contribution of SRF, Elk-1, and myocardin to airway smooth muscle remodeling in heaves, an asthma-like disease of horses

2015 ◽  
Vol 309 (1) ◽  
pp. L37-L45 ◽  
Author(s):  
Mylène Chevigny ◽  
Karine Guérin-Montpetit ◽  
Amandine Vargas ◽  
Josiane Lefebvre-Lavoie ◽  
Jean-Pierre Lavoie
Keyword(s):  
Smooth Muscle ◽  
Airway Smooth Muscle ◽  
Serum Response Factor ◽  
Smooth Muscles ◽  
Peripheral Airways ◽  
Myocyte Differentiation ◽  
Antigenic Exposure ◽  
Serum Response ◽  
Muscle Remodeling

Myocyte hyperplasia and hypertrophy contribute to the increased mass of airway smooth muscle (ASM) in asthma. Serum-response factor (SRF) is a transcription factor that regulates myocyte differentiation in vitro in vascular and intestinal smooth muscles. When SRF is associated with phosphorylated (p)Elk-1, it promotes ASM proliferation while binding to myocardin (MYOCD) leading to the expression of contractile elements in these tissues. The objective of this study was therefore to characterize the expression of SRF, pElk-1, and MYOCD in ASM cells from central and peripheral airways in heaves, a spontaneously occurring asthma-like disease of horses, and in controls. Six horses with heaves and five aged-matched controls kept in the same environment were studied. Nuclear protein expression of SRF, pElk-1, and MYOCD was evaluated in peripheral airways and endobronchial biopsies obtained during disease remission and after 1 and 30 days of naturally occurring antigenic exposure using immunohistochemistry and immunofluorescence techniques. Nuclear expression of SRF ( P = 0.03, remission vs. 30 days) and MYOCD ( P = 0.05, controls vs. heaves at 30 days) increased in the peripheral airways of horses with heaves during disease exacerbation, while MYOCD ( P = 0.04, remission vs. 30 days) decreased in the central airways of control horses. No changes were observed in the expression of pElk-1 protein in either tissue. In conclusion, SRF and its cofactor MYOCD likely contribute to the hypertrophy of peripheral ASM observed in equine asthmatic airways, while the remodeling of the central airways is more static or involves different transcription factors.

Neutrophil-Derived Exosomes: A New Mechanism Contributing to Airway Smooth Muscle Remodeling

2016 ◽  
Vol 55 (3) ◽  
pp. 450-461 ◽  
Author(s):  
Amandine Vargas ◽  
Florence Roux-Dalvai ◽  
Arnaud Droit ◽  
Jean-Pierre Lavoie
Keyword(s):  
Smooth Muscle ◽  
Airway Smooth Muscle ◽  
Muscle Remodeling
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