scholarly journals The role of estrogen receptor signaling in suppressing the immune response to cancer

2021 ◽  
Vol 131 (24) ◽  
Author(s):  
James M. Rae ◽  
Marc E. Lippman
Keyword(s):  
Immune Response ◽  
Estrogen Receptor ◽  
Receptor Signaling ◽  
Estrogen Receptor Signaling ◽  
Immune Response To Cancer

scholarly journals The role of estrogens and estrogen receptor signaling pathways in cancer and infertility: the case of schistosomes

2015 ◽  
Vol 31 (6) ◽  
pp. 246-250 ◽  
Author(s):  
Mónica C. Botelho ◽  
Helena Alves ◽  
Alberto Barros ◽  
Gabriel Rinaldi ◽  
Paul J. Brindley ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Signaling Pathways ◽  
Receptor Signaling ◽  
Estrogen Receptor Signaling

scholarly journals Antiestrogen resistance in breast cancer and the role of estrogen receptor signaling

Oncogene ◽  
2003 ◽  
Vol 22 (47) ◽  
pp. 7316-7339 ◽  
Author(s):  
Robert Clarke ◽  
Minetta C Liu ◽  
Kerrie B Bouker ◽  
Zhiping Gu ◽  
Richard Y Lee ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Antiestrogen Resistance ◽  
Receptor Signaling ◽  
Estrogen Receptor Signaling

Abstract 2101: Role of CDK8 in estrogen receptor signaling in breast cancers

2014 ◽  
Author(s):  
Martina McDermott ◽  
Balazs Gyorffy ◽  
Chang-uk Lim ◽  
Alexander Chumanevich ◽  
Zhengguan Yang ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Receptor Signaling ◽  
Breast Cancers ◽  
Estrogen Receptor Signaling

scholarly journals Role of direct estrogen receptor signaling in wear particle-induced osteolysis

Biomaterials ◽  
2013 ◽  
Vol 34 (3) ◽  
pp. 641-650 ◽  
Author(s):  
Christophe Nich ◽  
Allison J. Rao ◽  
Roberto D. Valladares ◽  
Chenguang Li ◽  
Jane E. Christman ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Wear Particle ◽  
Receptor Signaling ◽  
Estrogen Receptor Signaling

scholarly journals Fulvestrant-Mediated Inhibition of Estrogen Receptor Signaling Slows Lung Cancer Progression

2014 ◽  
Vol 22 (1) ◽  
pp. 13-20 ◽  
Author(s):  
Hexiao Tang ◽  
Yongde Liao ◽  
Chao Zhang ◽  
Guang Chen ◽  
Liqiang Xu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Estrogen Receptor ◽  
Cancer Progression ◽  
Estrogen Signaling ◽  
Control Group ◽  
Cancer Tissue ◽  
Mrna Levels ◽  
Receptor Signaling ◽  
Estrogen Receptor Signaling

Estrogens are key signaling molecules that regulate various physiological processes such as cell growth, development, and differentiation. They also play a major role in many pathological conditions, such as hormone-dependent cancer. The importance of inhibiting estrogen receptor signaling in diseases of estrogen target tissues, such as breast cancer, is well documented. However, the role of estrogen signaling in diseases of nontarget tissues, such as lung cancer, is not well characterized. The aim of the current study is to examine the expression of estrogen receptor (ER) and the roles of estradiol (E2) and fulvestrant on the progression of lung cancer. Tissue microarray (TMA) and immunohistochemistry (IHC) analyses were used to detect the expression of aromatase, ER, and ER in 198 patients. We performed analyses to determine if there was any correlation among these three proteins. A mouse model of urethane-induced lung adenocarcinoma was used in the study. Mice were divided into three treatment groups: blank control, E2 alone, and E2 + fulvestrant (ER antagonist). Western blot analysis and fluorescence quantitative PCR (FQ-PCR) were used to measure expression of ER protein and mRNA levels, respectively. ER, but not ER, was overexpressed in NSCLC samples. Lung cancer progression in mice treated with E2 was significantly increased compared to either the control group or the E2 + fulvestrant group. Mice in the E2 treatment group had significantly increased expression of ER at both the mRNA and protein levels compared to mice treated with E2 + fulvestrant or control. Our data suggest that ER promotes lung cancer progression in mice and that this progression can be inhibited with fulvestrant. These findings may help elucidate the role of ER in lung cancer and suggest that estrogen receptor antagonists, such as fulvestrant, may be therapeutically beneficial for the treatment of the disease.

Sign in / Sign up

Export Citation Format

Share Document