scholarly journals Therapeutic implications of activating noncanonical PIK3CA mutations in head and neck squamous cell carcinoma

2021 ◽  
Vol 131 (22) ◽  
Author(s):  
Nan Jin ◽  
Bhumsuk Keam ◽  
Janice Cho ◽  
Michelle J. Lee ◽  
Hye Ryun Kim ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Pik3ca Mutations ◽  
Therapeutic Implications

H-RAS and PIK3CA mutations and response to cetuximab in head and neck squamous cell carcinoma (HNSCC).

2011 ◽  
Vol 29 (15_suppl) ◽  
pp. 5513-5513 ◽  
Author(s):  
T. Rampias ◽  
A. Giagini ◽  
K. Florou ◽  
P. Gouveris ◽  
E. Vaja ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Pik3ca Mutations

scholarly journals Angiogenic heterogeneity in head and neck squamous cell carcinoma: biological and therapeutic implications

2008 ◽  
Vol 88 (4) ◽  
pp. 342-353 ◽  
Author(s):  
Rifat Hasina ◽  
Mark E Whipple ◽  
Leslie E Martin ◽  
Winston Patrick Kuo ◽  
Lucila Ohno-Machado ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Therapeutic Implications

scholarly journals Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Marcus M. Monroe ◽  
Eric C. Anderson ◽  
Daniel R. Clayburgh ◽  
Melissa H. Wong
Keyword(s):  
Stem Cells ◽  
Squamous Cell Carcinoma ◽  
Cancer Stem Cells ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Current Knowledge ◽  
Treatment Resistance ◽  
Neck Squamous Cell Carcinoma ◽  
Therapeutic Implications

Accumulating evidence suggests that self-renewal and differentiation capabilities reside only in a subpopulation of tumor cells, termed cancer stem cells (CSCs), whereas the remaining tumor cell population lacks the ability to initiate tumor development or support continued tumor growth. In head and neck squamous cell carcinoma (HNSCC), as with other malignancies, cancer stem cells have been increasingly shown to have an integral role in tumor initiation, disease progression, metastasis and treatment resistance. In this paper we summarize the current knowledge of the role of CSCs in HNSCC and discuss the therapeutic implications and future directions of this field.

scholarly journals PIK3CA Mutations in Head and Neck Squamous Cell Carcinoma

2006 ◽  
Vol 12 (5) ◽  
pp. 1441-1446 ◽  
Author(s):  
Wanglong Qiu ◽  
Frank Schönleben ◽  
Xiaojun Li ◽  
Daniel J. Ho ◽  
Lanny G. Close ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Pik3ca Mutations

scholarly journals Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma: Identification, Characterization and Clinical Implications

Cancers ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 616 ◽  
Author(s):  
Claudia Peitzsch ◽  
Jacqueline Nathansen ◽  
Sebastian I. Schniewind ◽  
Franziska Schwarz ◽  
Anna Dubrovska
Keyword(s):  
Stem Cells ◽  
Squamous Cell Carcinoma ◽  
Cancer Stem Cells ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Locally Advanced ◽  
Neck Squamous Cell Carcinoma ◽  
Therapeutic Implications ◽  
Patients At Risk

Head and neck squamous cell carcinoma (HNSCC) is the sixth most commonly diagnosed cancer worldwide. Despite advances in the treatment management, locally advanced disease has a poor prognosis, with a 5-year survival rate of approximately 50%. The growth of HNSCC is maintained by a population of cancer stem cells (CSCs) which possess unlimited self-renewal potential and induce tumor regrowth if not completely eliminated by therapy. The population of CSCs is not only a promising target for tumor treatment, but also an important biomarker to identify the patients at risk for therapeutic failure and disease progression. This review aims to provide an overview of the recent pre-clinical and clinical studies on the biology and potential therapeutic implications of HNSCC stem cells.

Radioresistance in head and neck squamous cell carcinoma: Biological bases and therapeutic implications

Head & Neck ◽  
2015 ◽  
Vol 37 (5) ◽  
pp. 763-770 ◽  
Author(s):  
Francesco Perri ◽  
Roberto Pacelli ◽  
Giuseppina Della Vittoria Scarpati ◽  
Laura Cella ◽  
Mario Giuliano ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Therapeutic Implications

Feasibility of Targeting PIK3CA Mutations in Head and Neck Squamous Cell Carcinoma

2015 ◽  
Vol 22 (1) ◽  
pp. 35-40 ◽  
Author(s):  
Julie A. Theurer ◽  
William Stecho ◽  
John Yoo ◽  
Keith Kwan ◽  
Bret Wehrli ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Pik3ca Mutations
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