scholarly journals BCG turns 100: its nontraditional uses against viruses, cancer, and immunologic diseases

2021 ◽  
Vol 131 (11) ◽  
Author(s):  
Alok K. Singh ◽  
Mihai G. Netea ◽  
William R. Bishai
Keyword(s):  
Immunologic Diseases

scholarly journals Covid-19 Pandemic Era: Is It Time To Promote Home Dialysis And Peritoneal Dialysis?

2021 ◽  
Author(s):  
Mario Cozzolino ◽  
Ferruccio Conte ◽  
Fulvia Zappulo ◽  
Paola Ciceri ◽  
Andrea Galassi ◽  
...  
Keyword(s):  
Severe Infection ◽  
Human Interaction ◽  
World Health ◽  
Older Individuals ◽  
Home Dialysis ◽  
Renal Replacement Therapies ◽  
Home Based ◽  
Immunologic Diseases ◽  
Novel Coronavirus ◽  
Health Organization

ABSTRACT The novel coronavirus, called SARS-CoV-2 has been declared a pandemic on March 2020, by the World Health Organization. Older individuals and patients with comorbid conditions such as hypertension, heart disease, diabetes, lung disease, chronic kidney disease (CKD), and immunologic diseases are at higher risk of contracting this severe infection. In particular, patients with advanced CKD constitute a vulnerable population and a challenge in the prevention and control of the disease. Home-based renal replacement therapies offer opportunity to manage patients remotely, thus reducing the likelihood of infection due to direct human interaction. Patients are seen less frequently, limiting the close interaction between patients and healthcare workers who may contract and spread the disease. On the other hand, while home dialysis is reasonable selection at his time due to the advantage of isolation of patients, measures must be assured to implement the program. Despite its logistical benefits, outpatient hemodialysis also presents certain challenges during times of crises such as COVID 19 pandemic and potentially future ones.

scholarly journals Where Are You Going, Nephrology? Considerations on Models of Care in an Evolving Discipline

2018 ◽  
Vol 7 (8) ◽  
pp. 199 ◽  
Author(s):  
Giorgina Piccoli ◽  
Conrad Breuer ◽  
Gianfranca Cabiddu ◽  
Angelo Testa ◽  
Christelle Jadeau ◽  
...  
Keyword(s):  
Internal Medicine ◽  
Kidney Disease ◽  
Kidney Diseases ◽  
Models Of Care ◽  
Scientific Model ◽  
Dialysis Treatment ◽  
Cost Constraints ◽  
Common Diseases ◽  
Nephrology Care ◽  
Immunologic Diseases

Nephrology is a complex discipline, including care of kidney disease, dialysis, and transplantation. While in Europe, about 1:10 individuals is affected by chronic kidney disease (CKD), 1:1000 lives thanks to dialysis or transplantation, whose costs are as high as 2% of all the health care budget. Nephrology has important links with surgery, bioethics, cardiovascular and internal medicine, and is, not surprisingly, in a delicate balance between specialization and comprehensiveness, development and consolidation, cost constraints, and competition with internal medicine and other specialties. This paper proposes an interpretation of the different systems of nephrology care summarising the present choices into three not mutually exclusive main models (“scientific”, “pragmatic”, “holistic”, or “comprehensive”), and hypothesizing an “ideal-utopic” prevention-based fourth one. The so-called scientific model is built around kidney transplantation and care of glomerulonephritis and immunologic diseases, which probably pose the most important challenges in our discipline, but do not mirror the most common clinical problems. Conversely, the pragmatic one is built around dialysis (the most expensive and frequent mode of renal replacement therapy) and pre-dialysis treatment, focusing attention on the most common diseases, the holistic, or comprehensive, model comprehends both, and is integrated by several subspecialties, such as interventional nephrology, obstetric nephrology, and the ideal-utopic one is based upon prevention, and early care of common diseases. Each model has strength and weakness, which are commented to enhance discussion on the crucial issue of the philosophy of care behind its practical organization. Increased reflection and research on models of nephrology care is urgently needed if we wish to rise to the challenge of providing earlier and better care for older and more complex kidney patients with acute and chronic kidney diseases, with reduced budgets.

scholarly journals Impact of patient programs on adherence and persistence in inflammatory and immunologic diseases: a meta-analysis

2015 ◽  
pp. 435 ◽  
Author(s):  
Chakkarin Burudpakdee ◽  
Zeba M Khan ◽  
Merena Nanavaty ◽  
Satyin Kaura ◽  
Smeet Gala
Keyword(s):  
Meta Analysis ◽  
Immunologic Diseases

Biologics in allergic and immunologic diseases

2018 ◽  
Vol 120 (4) ◽  
pp. 350-353 ◽  
Author(s):  
Mauli Desai ◽  
John Oppenheimer
Keyword(s):  
Immunologic Diseases

Immunology in Clinical Medicine, ed. 2, by J. L. Turk, M.D., D.Sc. (Lond.), M.R.C.P., M.R.C. Path. New York: Appleton-Century-Crofts, 1972, 259 pp., $9.75

PEDIATRICS ◽  
1974 ◽  
Vol 53 (4) ◽  
pp. 591-591
Author(s):  
Paul G. Quie
Keyword(s):  
New York ◽  
Clinical Medicine ◽  
Underlying Disease ◽  
Immunologic Diseases

This second edition (1972) of Dr. Turk's book "Immunology in Clinical Medicine," first published in 1969, is a welcome guide for clinicians in the tangled pathways of immunologic information. As in the first edition, Dr. Turk has provided his readers with concepts of immunology underlying disease processes. The author is ever mindful that his reader is concerned with patients, and the information about immunologic concepts is intended to provide helpful understanding of the pathophysiology of immunologic diseases.

scholarly journals Expression of Matrix Metalloproteinases and Their Tissue Inhibitors in Chronic Rhinosinusitis With Nasal Polyps: Etiopathogenesis and Recurrence

2020 ◽  
pp. 014556131989663
Author(s):  
Germano Guerra ◽  
Domenico Testa ◽  
Francesco Antonio Salzano ◽  
Domenico Tafuri ◽  
Eleonora Hay ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Matrix Metalloproteinases ◽  
Chronic Rhinosinusitis ◽  
Nasal Polyps ◽  
Polymerase Chain Reaction Analysis ◽  
Sinus Surgery ◽  
Control Group ◽  
Nonallergic Rhinitis ◽  
Tissue Inhibitors ◽  
Immunologic Diseases

Chronic rhinosinusitis with nasal polyps is a multifactorial disease of the nasal and paranasal sinus mucosa and it includes, as comorbidities, anatomic and morphologic alterations, allergic rhinitis, and immunologic diseases. We investigated matrix metalloproteinases (MMP-2, MMP-7, and MMP-9) and their tissue inhibitors (TIMP-1 and TIMP-2) concentration in different etiopathogenetical groups of patients with nasal polyposis (NP) in relation to recurrence after sinonasal surgery. The study group consisted of 45 patients with NP (those with allergic rhinitis, nonallergic rhinitis and asthma or nonallergic rhinitis, and obstruction of osteomeatal complex [OMC]) who underwent endonasal sinus surgery. We also collected 10 patients who underwent septoplasty as control. Immunohistochemistry of nasal mucosa fragments, Western blotting, and polymerase chain reaction analysis showed increased MMPs levels (MMP-9 more than MMP-2 and MMP-7) and decreased tissue inhibitors of MMPs levels (TIMP-1 less than TIMP-2), in patients with chronic rhinosinusitis with nasal polyps compared with control group, in particular in patients with nonallergic rhinitis and asthma compared to those with allergic rhinitis and nonallergic rhinitis and obstruction of OMC. We observed a higher risk of recurrence in patients with nonallergic rhinitis and asthma than in those with allergic rhinitis and nonallergic rhinitis and obstruction of OMC after 36 months from surgery. In this research, we evaluated pathogenesis of NP related to MMPs and their inhibitors concentrations in polypoid tissue.

scholarly journals Immunology and Immunologic Diseases of the Lung

Thorax ◽  
1989 ◽  
Vol 44 (4) ◽  
pp. 313-313
Author(s):  
Keyword(s):  
Immunologic Diseases
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