scholarly journals UDP-glucose and P2Y14 receptor amplify allergen-induced airway eosinophilia

2021 ◽  
Vol 131 (7) ◽  
Author(s):  
Tadeusz P. Karcz ◽  
Gregory S. Whitehead ◽  
Keiko Nakano ◽  
Hideki Nakano ◽  
Sara A. Grimm ◽  
...  
Keyword(s):  
Airway Eosinophilia

scholarly journals The JAK1/2 inhibitor baricitinib suppresses eosinophil effector function and restricts allergen-induced airway eosinophilia

2021 ◽  
pp. 114690
Author(s):  
Petra Luschnig ◽  
Melanie Kienzl ◽  
David Roula ◽  
Johannes Pilic ◽  
Reham Atallah ◽  
...  
Keyword(s):  
Effector Function ◽  
Airway Eosinophilia

scholarly journals Regulation of Eosinophilia in Asthma—New Therapeutic Approaches for Asthma Treatment

Cells ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 817
Author(s):  
Ruth P. Cusack ◽  
Christiane E. Whetstone ◽  
Yanqing Xie ◽  
Maral Ranjbar ◽  
Gail M. Gauvreau
Keyword(s):  
Drug Targets ◽  
Airflow Obstruction ◽  
Chronic Inflammatory Disease ◽  
Therapeutic Approaches ◽  
Eosinophilic Asthma ◽  
Airway Eosinophilia ◽  
Gm Csf ◽  
New Therapeutic Approaches ◽  
Cellular Apoptosis ◽  
Reversible Airflow Obstruction

Asthma is a complex and chronic inflammatory disease of the airways, characterized by variable and recurring symptoms, reversible airflow obstruction, bronchospasm, and airway eosinophilia. As the pathophysiology of asthma is becoming clearer, the identification of new valuable drug targets is emerging. IL-5 is one of these such targets because it is the major cytokine supporting eosinophilia and is responsible for terminal differentiation of human eosinophils, regulating eosinophil proliferation, differentiation, maturation, migration, and prevention of cellular apoptosis. Blockade of the IL-5 pathway has been shown to be efficacious for the treatment of eosinophilic asthma. However, several other inflammatory pathways have been shown to support eosinophilia, including IL-13, the alarmin cytokines TSLP and IL-33, and the IL-3/5/GM-CSF axis. These and other alternate pathways leading to airway eosinophilia will be described, and the efficacy of therapeutics that have been developed to block these pathways will be evaluated.

scholarly journals CTLA4Ig Inhibits Airway Eosinophilia and Hyperresponsiveness by Regulating the Development of Th1/Th2 Subsets in a Murine Model of Asthma

1998 ◽  
Vol 18 (4) ◽  
pp. 453-462 ◽  
Author(s):  
Philip A. Padrid ◽  
Mudit Mathur ◽  
Xiantang Li ◽  
Karin Herrmann ◽  
Yimin Qin ◽  
...  
Keyword(s):  
Murine Model ◽  
Airway Eosinophilia

High-fat feeding redirects cytokine responses and decreases allergic airway eosinophilia

2009 ◽  
Vol 39 (5) ◽  
pp. 731-739 ◽  
Author(s):  
A. de Vries ◽  
L. Hazlewood ◽  
P. M. Fitch ◽  
J. R. Seckl ◽  
P. Foster ◽  
...  
Keyword(s):  
High Fat ◽  
Airway Eosinophilia ◽  
Cytokine Responses ◽  
Fat Feeding

scholarly journals Similar immune mechanisms control experimental airway eosinophilia elicited by different allergens and treatment protocols

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Evelyn J. Hyde ◽  
Kirsty A. Wakelin ◽  
Naomi J. Daniels ◽  
Sayani Ghosh ◽  
Franca Ronchese
Keyword(s):  
Treatment Protocols ◽  
Airway Eosinophilia ◽  
Immune Mechanisms

IFN-γ secretion by CD8+T cells inhibits allergen-induced airway eosinophilia but not late airway responses

2002 ◽  
Vol 109 (5) ◽  
pp. 803-809 ◽  
Author(s):  
Masaru Suzuki ◽  
Karim Maghni ◽  
Sophie Molet ◽  
Ayako Shimbara ◽  
Qutayba A. Hamid ◽  
...  
Keyword(s):  
T Cells ◽  
Cd8 T Cells ◽  
Airway Eosinophilia ◽  
Ifn Γ ◽  
Airway Responses

scholarly journals Mast cells contribute to double-stranded RNA-induced augmentation of airway eosinophilia in a murine model of asthma

2013 ◽  
Vol 14 (1) ◽  
pp. 28 ◽  
Author(s):  
Keiko Kan-o ◽  
Yuko Matsunaga ◽  
Satoru Fukuyama ◽  
Atsushi Moriwaki ◽  
Hiroko Hirai-Kitajima ◽  
...  
Keyword(s):  
Mast Cells ◽  
Murine Model ◽  
Double Stranded Rna ◽  
Airway Eosinophilia
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