scholarly journals An experiment of nature: genetic l-arginine deficiency and NO insufficiency

2001 ◽  
Vol 108 (5) ◽  
pp. 663-664 ◽  
Author(s):  
Joseph Loscalzo
Keyword(s):  
Nature Genetic ◽  
Arginine Deficiency

scholarly journals Alteration of serum amino acid profiles by dietary adenine supplementation inhibits fatty liver development in rats

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Hiroki Nishi ◽  
Daisuke Yamanaka ◽  
Masato Masuda ◽  
Yuki Goda ◽  
Koichi Ito ◽  
...  
Keyword(s):  
Amino Acid ◽  
Fatty Liver ◽  
Causative Factor ◽  
Amino Acid Profile ◽  
Liver Development ◽  
Concentration Data ◽  
Amino Acid Profiles ◽  
Arginine Deficiency ◽  
Branched Chain ◽  
Tag Accumulation

AbstractStudies on animal models have demonstrated that feeding a low-arginine diet inhibits triacylglycerol (TAG) secretion from the liver, resulting in marked fatty liver development in rats. Here, we first showed that culturing hepatocytes in the medium mimicking the serum amino acid profile of low-arginine diet-fed rats induced TAG accumulation in the cells, indicating that the specific amino acid profile caused TAG accumulation in hepatocytes. Dietary adenine supplementation completely recovered hepatic TAG secretion and abolished hepatic TAG accumulation in rats. A comprehensive non-linear analysis revealed that inhibition of hepatic TAG accumulation by dietary adenine supplementation could be predicted using only serum amino acid concentration data. Comparison of serum amino acid concentrations indicated that histidine, methionine, and branched-chain amino acid (BCAA) concentrations were altered by adenine supplementation. Furthermore, when the serum amino acid profiles of low-arginine diet-fed rats were altered by modifying methionine or BCAA concentrations in their diets, their hepatic TAG accumulation was abolished. Altogether, these results suggest that an increase in methionine and BCAA levels in the serum in response to dietary arginine deficiency is a key causative factor for hepatic TAG accumulation, and dietary adenine supplementation could disrupt this phenomenon by altering serum amino acid profiles.

Using Genetic Algorithms to Develop Investment Strategies

2021 ◽  
pp. 197-214
Keyword(s):  
Genetic Algorithms ◽  
Large Degree ◽  
Human Mind ◽  
Trading Strategies ◽  
Investment Strategies ◽  
Nature Genetic ◽  
Search Technique ◽  
Combined Model ◽  
Stock Trading ◽  
Trading Systems

Genetic algorithms (GAs) are a powerful search technique. The use of genetic algorithms (GAs) will help in the development of better trading systems. The genetic algorithms (GAs) help the researcher to explore various combinations of trading rules or their parameters, which the human mind is unable to find. This chapter explains genetic algorithms (GAs) in brief and gives insight on how they find better trading strategies. Some of the manual trading strategies are good in nature. Genetic algorithms (GAs) only addition to them. Interfacing genetic algorithms (GAs) with stock trading systems or developing a combined model requires a large degree of imagination and creativity. It is an art not a scientific invention. Genetic algorithms (GAs) make use of computers to find various interesting trading systems.

Effect of Arginine Deficiency on Synthesis of DNA and Immunoglobulin Receptor of Burkitt Lymphoma Cells

Nature ◽  
1970 ◽  
Vol 227 (5256) ◽  
pp. 398-399 ◽  
Author(s):  
B. O. OSUNKOYA ◽  
W. H. ADLER ◽  
R. T. SMITH
Keyword(s):  
Burkitt Lymphoma ◽  
Lymphoma Cells ◽  
Immunoglobulin Receptor ◽  
Arginine Deficiency

Arginine Deficiency during Gestation and Lactation in the Rat

1981 ◽  
Vol 111 (1) ◽  
pp. 184-193 ◽  
Author(s):  
M. Y. Pau ◽  
J. A. Milner
Keyword(s):  
Arginine Deficiency

scholarly journals Dietary Protein or Arginine Deficiency Impairs Constitutive and Inducible Nitric Oxide Synthesis by Young Rats

1999 ◽  
Vol 129 (7) ◽  
pp. 1347-1354 ◽  
Author(s):  
Guoyao Wu ◽  
Nick E. Flynn ◽  
Sean P. Flynn ◽  
Christopher A. Jolly ◽  
Paula K. Davis
Keyword(s):  
Nitric Oxide ◽  
Dietary Protein ◽  
Nitric Oxide Synthesis ◽  
Young Rats ◽  
Arginine Deficiency ◽  
Inducible Nitric Oxide

scholarly journals Characterization of the argA Gene Required for Arginine Biosynthesis and Syringomycin Production by Pseudomonas syringae pv. syringae

2003 ◽  
Vol 69 (12) ◽  
pp. 7273-7280 ◽  
Author(s):  
Shi-En Lu ◽  
Jonathan D. Soule ◽  
Dennis C. Gross
Keyword(s):  
Pseudomonas Syringae ◽  
Culture Media ◽  
Toxin Production ◽  
Arginine Biosynthesis ◽  
Reading Frame ◽  
High Conservation ◽  
Plant Pathogenicity ◽  
Arginine Deficiency ◽  
Dna Fragment

ABSTRACT Two types of necrosis-inducing lipodepsipeptide toxins, called syringomycin and syringopeptin, are major virulence factors of Pseudomonas syringae pv. syringae strain B301D. A previous study showed that a locus, called syrA, was required for both syringomycin production and plant pathogenicity, and the syrA locus was speculated to encode a regulator of toxin production. In this study, sequence analysis of the 8-kb genomic DNA fragment that complements the syrA phenotype revealed high conservation among a broad spectrum of fluorescent pseudomonads. The putative protein encoded by open reading frame 4 (ORF4) (1,299 bp) in the syrA locus region exhibited 85% identity to ArgA, which is involved in arginine biosynthesis in Pseudomonas aeruginosa. Growth of strain W4S2545, the syrA mutant, required supplementation of N minimal medium with arginine. Similarly, syringomycin production of syrA mutant W4S2545 was restored by the addition of arginine to culture media. Furthermore, the insertion of Tn5 in the genome of the syrA mutant W4S2545 was localized between nucleotides 146 and 147 in ORF4, and syringomycin production was complemented in trans with the wild-type DNA fragment containing intact ORF4. These results demonstrate that the syrA locus is the argA gene of P. syringae pv. syringae and that argA is directly involved in arginine biosynthesis and therefore indirectly affects syringomycin production because of arginine deficiency.

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