scholarly journals Revealing the molecular signaling pathways of mucus stasis in cystic fibrosis

2019 ◽  
Vol 129 (10) ◽  
pp. 4089-4090 ◽  
Author(s):  
Susan E. Birket ◽  
Steven M. Rowe
Keyword(s):  
Cystic Fibrosis ◽  
Signaling Pathways ◽  
Molecular Signaling ◽  
Molecular Signaling Pathways

scholarly journals Fibrosis after Myocardial Infarction: An Overview on Cellular Processes, Molecular Pathways, Clinical Evaluation and Prognostic Value

2021 ◽  
Vol 9 (1) ◽  
pp. 16
Author(s):  
Renato Francesco Maria Scalise ◽  
Rosalba De Sarro ◽  
Alessandro Caracciolo ◽  
Rita Lauro ◽  
Francesco Squadrito ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Signaling Pathways ◽  
Ventricular Dysfunction ◽  
Healing Process ◽  
Molecular Signaling ◽  
Cellular Processes ◽  
Molecular Signaling Pathways ◽  
Fibrotic Scar ◽  
Life Threatening

The ischemic injury caused by myocardial infarction activates a complex healing process wherein a powerful inflammatory response and a reparative phase follow and balance each other. An intricate network of mediators finely orchestrate a large variety of cellular subtypes throughout molecular signaling pathways that determine the intensity and duration of each phase. At the end of this process, the necrotic tissue is replaced with a fibrotic scar whose quality strictly depends on the delicate balance resulting from the interaction between multiple actors involved in fibrogenesis. An inflammatory or reparative dysregulation, both in term of excess and deficiency, may cause ventricular dysfunction and life-threatening arrhythmias that heavily affect clinical outcome. This review discusses cellular process and molecular signaling pathways that determine fibrosis and the imaging technique that can characterize the clinical impact of this process in-vivo.

scholarly journals Transcriptome dynamics in early in vivo developing and in vitro produced porcine embryos

2020 ◽  
Author(s):  
Vera A van der Weijden ◽  
Meret Schmidhauser ◽  
Mayuko Kurome ◽  
Johannes Knubben ◽  
Veronika L Flöter ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Early Stage ◽  
Developmental Competence ◽  
Molecular Signaling ◽  
Developmental Potential ◽  
Stage Of Development ◽  
Molecular Signaling Pathways ◽  
Canonical Pathways

Abstract Background: The transcriptional changes around the time of embryonic genome activation in pre-implantation embryos indicate that this process is highly dynamic. In vitro produced porcine blastocysts are known to be less competent than in vivo developed blastocysts. To understand the conditions that compromise developmental competence of in vitro embryos, it is crucial to evaluate the transcriptional profile of porcine embryos during pre-implantation stages. In this study, we investigated the transcriptome dynamics in in vivo developed and in vitro produced 4-cell embryos, morulae and hatched blastocysts.Results: In vivo developed and in vitro produced embryos displayed largely similar transcriptome profiles during development. Enriched canonical pathways from the 4-cell to the morula transition that were shared between in vivo developed and in vitro produced embryos included oxidative phosphorylation, tRNA charging, and EIF2 signaling. The shared canonical pathways from the morula to the hatched blastocyst transition were 14-3-3-mediated signaling, signaling of Rho family GTPases, and NRF2-mediated oxidative stress response. The in vivo developed and in vitro produced hatched blastocysts were compared to identify molecular signaling pathways indicative of lower developmental competence of in vitro produced hatched blastocysts. A higher metabolic rate and expression of the arginine transporter SLC7A1 were found in in vitro produced hatched blastocysts.Conclusions: Our findings suggest that embryos with compromised developmental potential are arrested at an early stage of development, while embryos developing to the hatched blastocyst stage display largely similar transcriptome profiles, irrespective of the embryo source. The hatched blastocysts derived from the in vitro fertilization-pipeline showed an enrichment in molecular signaling pathways associated with lower developmental competence, compared to the in vivo developed embryos.

Deoxyelephantopin impairs growth of cervical carcinoma SiHa cells and induces apoptosis by targeting multiple molecular signaling pathways

2014 ◽  
Vol 30 (6) ◽  
pp. 331-343 ◽  
Author(s):  
Arakkaveettil Kabeer Farha ◽  
Sethumadhavannair Rajalekshmi Dhanya ◽  
Sivasankaran Nair Mangalam ◽  
Balakrishnan Sreedevi Geetha ◽  
Panickamparambil Gopalakrishnan Latha ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Cervical Carcinoma ◽  
Molecular Signaling ◽  
Siha Cells ◽  
Molecular Signaling Pathways

Cancerous perturbations within the ERK, PI3K/Akt, and Wnt/β-catenin signaling network constitutively activate inter-pathway positive feedback loops

2017 ◽  
Vol 13 (5) ◽  
pp. 830-840 ◽  
Author(s):  
Rahul Rao Padala ◽  
Rishabh Karnawat ◽  
Satish Bharathwaj Viswanathan ◽  
Abhishek Vijay Thakkar ◽  
Asim Bikas Das
Keyword(s):  
Signaling Pathways ◽  
Malignant Transformation ◽  
Positive Feedback ◽  
Feedback Loops ◽  
Signaling Network ◽  
Molecular Signaling ◽  
Activated State ◽  
Molecular Signaling Pathways

Perturbations in molecular signaling pathways result in a constitutively activated state, leading to malignant transformation of cells.

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