scholarly journals Calcium-dependent blood-brain barrier breakdown by NOX5 limits postreperfusion benefit in stroke

2019 ◽  
Vol 129 (4) ◽  
pp. 1772-1778 ◽  
Author(s):  
Ana I. Casas ◽  
Pamela W.M. Kleikers ◽  
Eva Geuss ◽  
Friederike Langhauser ◽  
Thure Adler ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Calcium Dependent ◽  
Blood Brain ◽  
Barrier Breakdown ◽  
Blood Brain Barrier Breakdown

scholarly journals Calcium-dependent reactive oxygen formation and blood-brain barrier breakdown by NOX5 limits post-reperfusion outcome in stroke

2018 ◽  
Author(s):  
Ana I Casas ◽  
Pamela WM Kleikers ◽  
Eva Geuss ◽  
Friederike Langhauser ◽  
Javier Egea ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Infarct Volume ◽  
Reactive Oxygen ◽  
Brain Barrier ◽  
Dependent Manner ◽  
Calcium Dependent ◽  
Mechanical Removal ◽  
Blood Brain ◽  
Barrier Breakdown ◽  
Blood Brain Barrier Breakdown

AbstractIschemic stroke is a predominant cause of disability worldwide, with thrombolytic or mechanical removal of the occlusion being the only therapeutic options. Reperfusion bears the risk of an acute deleterious calcium-dependent breakdown of the blood-brain-barrier. Its mechanism, however, is unknown. Here we identify type 5 NADPH oxidase (NOX5), a calcium-activated, reactive oxygen species (ROS)-forming enzyme as missing link. Using a humanised knock-in mouse model and in vitro in organotypic cultures, we find re-oxygenation or calcium overload to increase brain ROS levels in a NOX5-dependent manner. In vivo, post-ischemic ROS formation, infarct volume and functional outcomes were worsened in NOX5 knock-in mice. Of clinical and therapeutic relevance, in a human blood-barrier model pharmacological NOX inhibition also prevented acute re-oxygenation induced leakage. Our data therefore identify NOX5 as sufficient to induce acute post-reperfusion calcium-dependent blood-brain-barrier breakdown. We suggest urgent clinical validation by conducting protective post-stroke re-canalisation in the presence of a NOX inhibitor.

scholarly journals Evidences of endocytosis via caveolae following blood–brain barrier breakdown by Phoneutria nigriventer spider venom

2014 ◽  
Vol 229 (3) ◽  
pp. 415-422 ◽  
Author(s):  
Edilene Siqueira Soares ◽  
Monique Culturato Padilha Mendonça ◽  
Silvia Pierre Irazusta ◽  
Andressa Coope ◽  
Leila Miguel Stávale ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Spider Venom ◽  
Blood Brain ◽  
Barrier Breakdown ◽  
Blood Brain Barrier Breakdown ◽  
Phoneutria Nigriventer

Blood-brain barrier breakdown, neuroinflammation, and cognitive decline in older adults

2018 ◽  
Vol 14 (12) ◽  
pp. 1640-1650 ◽  
Author(s):  
Gene L. Bowman ◽  
Loïc Dayon ◽  
Richard Kirkland ◽  
Jérôme Wojcik ◽  
Gwendoline Peyratout ◽  
...  
Keyword(s):  
Older Adults ◽  
Cognitive Decline ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Blood Brain ◽  
Barrier Breakdown ◽  
Blood Brain Barrier Breakdown
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