scholarly journals T-cell involvement in drug-induced acute generalized exanthematous pustulosis

2001 ◽  
Vol 107 (11) ◽  
pp. 1433-1441 ◽  
Author(s):  
Markus Britschgi ◽  
Urs C. Steiner ◽  
Simone Schmid ◽  
Jan P.H. Depta ◽  
Gabriela Senti ◽  
...  
Keyword(s):  
T Cell ◽  
Drug Induced ◽  
Acute Generalized Exanthematous Pustulosis ◽  
Exanthematous Pustulosis

Acute Generalized Exanthematous Pustulosis With Multiple Organ Dysfunction Syndrome

2013 ◽  
Vol 22 (3) ◽  
pp. 270-273 ◽  
Author(s):  
Ghulam Rehman Mohyuddin ◽  
Manar Al Asad ◽  
Lindsay Scratchko ◽  
Ghulam Khaleeq
Keyword(s):  
Lower Extremity ◽  
Rare Condition ◽  
Skin Condition ◽  
Multiple Organ ◽  
Drug Induced ◽  
Acute Generalized Exanthematous Pustulosis ◽  
Left Lower Extremity ◽  
Causative Drug ◽  
Diffuse Erythema ◽  
Exanthematous Pustulosis

Acute generalized exanthematous pustulosis is a rare condition characterized by sterile pustules on erythematous and edematous tissue. Mostly drug induced, this condition can also be caused by other factors. Cases due to vancomycin are rare. A 67-year-old woman with cellulitis of the left lower extremity was admitted with marked bilateral lymphedema of the lower extremities and diffuse erythema of the left lower extremity from foot to knee. She was given clindamycin and then vancomycin. On day 5, her condition worsened, with erythema involving the entire back. Although treatment with clindamycin and vancomycin was discontinued, acute generalized exanthematous pustulosis developed. After successful treatment of other complications, the skin condition improved. Because vancomycin is frequently used, clinicians should be aware of the possibility of acute generalized exanthematous pustulosis. Because the pustulosis decreases after withdrawal of the causative drug, being able to diagnose and differentiate the abnormality from other conditions is prudent.

scholarly journals Acute generalized exanthematous pustulosis (AGEP). Case report

2005 ◽  
Vol 47 (3) ◽  
pp. 171-176 ◽  
Author(s):  
Walter Belda Junior ◽  
Ana Carolina Junqueira Ferolla
Keyword(s):  
Antidepressant Drugs ◽  
Corticosteroid Treatment ◽  
Beta Lactam ◽  
Drug Induced ◽  
Acute Generalized Exanthematous Pustulosis ◽  
Outpatient Unit ◽  
Similar Drug ◽  
Generalized Pustular Psoriasis ◽  
Inflammatory Drugs ◽  
Exanthematous Pustulosis

Acute Generalized Exanthematous Pustulosis (AGEP) is a drug-induced dermatosis characterized by an acute episode of sterile pustules over erythematous-edematous skin. It is accompanied by an episode of fever, which regresses a few days after discontinuation of the drug that caused the condition or as a result of corticosteroid treatment. The main triggering drugs are antibiotics, mainly beta-lactam ones. Other medications, such as antifungal agents, non steroid anti-inflammatory drugs, analgesics, antiarrhythmic, anticonvulsant and antidepressant drugs, may also be responsible. Histologically, it is characterized by the existence of vasculitis, associated with non-follicular subcorneal pustules. A case of a Caucasian female outpatient unit of Dermatology with AGEP, who presented with generalized pustulosis lesions after the use of cephalosporin for urinary infection is related. The diagnosis was confirmed by the clinical and pathological correlations, the resolution of the dermatosis after discontinuation of the drug and use of systemic corticosteroid treatment, and the recurrence of the disorder after the introduction of a similar drug. The importance of the recognition of this drug-induced dermatosis is given by its main differential clinical and histological diagnoses: generalized pustular psoriasis and subcorneal pustulosis.

Acute Generalized Exanthematous Pustulosis Induced by Amoxicillin/Clavulanic Acid

2015 ◽  
Vol 19 (6) ◽  
pp. 592-594 ◽  
Author(s):  
Ekaterini Syrigou ◽  
Dimitra Grapsa ◽  
Andriani Charpidou ◽  
Konstantinos Syrigos
Keyword(s):  
Clavulanic Acid ◽  
Patch Testing ◽  
Clinical Presentation ◽  
Drug Induced ◽  
Acute Generalized Exanthematous Pustulosis ◽  
Amoxicillin Clavulanic Acid ◽  
Exanthematous Pustulosis ◽  
Histopathologic Features

Drug-induced acute generalized exanthematous pustulosis is a rare pustular skin reaction, most commonly triggered by antibiotics. Although its diagnosis is based primarily on the presence of specific clinical and histopathologic features, additional in vivo (patch testing) or in vitro testing may be required, especially in atypical cases, to more accurately determine the causative agent. The authors report a histologically confirmed case of acute generalized exanthematous pustulosis that was induced by amoxicillin/clavulanic acid, as documented by subsequent patch testing, and presented with generalized painful lymphadenopathy, mimicking an acute infectious process. This is a very rare and diagnostically challenging clinical presentation of acute generalized exanthematous pustulosis, which has been reported, to the best of our knowledge, only once previously.

scholarly journals Case report: Acute Localized Exanthematous Pustulosis Following mRNA-1273 SARS-CoV-2 Vaccination

2021 ◽  
Vol 8 (5) ◽  
pp. 01-03
Author(s):  
Peter A. Young ◽  
Jessica B. Chan ◽  
Michael W. Su
Keyword(s):  
Case Report ◽  
T Cell ◽  
Young Adult ◽  
Inflammatory Response ◽  
Adult Female ◽  
Messenger Rna ◽  
Clinical Appearance ◽  
Acute Generalized Exanthematous Pustulosis ◽  
The Face ◽  
Exanthematous Pustulosis

Acute localized exanthematous pustulosis (ALEP) is a rare subtype of acute generalized exanthematous pustulosis (AGEP) with identical histologic findings. It results from a T-cell related neutrophilic inflammatory response and is characterized by monomorphic sterile pustules confined to the face, neck, or chest. Two cases of similar facial pustular eruptions in association with the messenger RNA–1273 SARS-CoV-2 vaccine have been reported, both in males of lighter skin over 50 years old. To highlight this rare reaction and its clinical appearance in patients of pigment-rich skin, we report the case of a young adult female with ALEP following injection of the RNA–1273 SARS-CoV-2 vaccine.

DRUG-INDUCED ACUTE GENERALIZED EXANTHEMATOUS PUSTULOSIS WITH POSITIVE PATCH TESTS

1995 ◽  
Vol 34 (4) ◽  
pp. 263-266 ◽  
Author(s):  
ANNE MOREAU ◽  
ANNE DOMPMARTIN ◽  
BRIGITTE CASTEL ◽  
BRIGITTE REMOND ◽  
DOMINIQUE LEROY
Keyword(s):  
Drug Induced ◽  
Patch Tests ◽  
Acute Generalized Exanthematous Pustulosis ◽  
Exanthematous Pustulosis
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