The mitogen-activated protein kinase pathway can mediate growth inhibition and proliferation in smooth muscle cells. Dependence on the availability of downstream targets.

K E Bornfeldt; J S Campbell; H Koyama; G M Argast; C C Leslie; E W Raines; E G Krebs; R Ross

doi:10.1172/jci119603

The mitogen-activated protein kinase pathway can mediate growth inhibition and proliferation in smooth muscle cells. Dependence on the availability of downstream targets.

Journal of Clinical Investigation ◽

10.1172/jci119603 ◽

1997 ◽

Vol 100 (4) ◽

pp. 875-885 ◽

Cited By ~ 112

Author(s):

K E Bornfeldt ◽

J S Campbell ◽

H Koyama ◽

G M Argast ◽

C C Leslie ◽

...

Keyword(s):

Smooth Muscle ◽

Protein Kinase ◽

Smooth Muscle Cells ◽

Growth Inhibition ◽

Muscle Cells ◽

Mitogen Activated Protein Kinase ◽

Downstream Targets ◽

Mitogen Activated Protein ◽

Kinase Pathway

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Insulin stimulates endogenous angiotensin II production via a mitogen-activated protein kinase pathway in vascular smooth muscle cells

Journal of Hypertension ◽

10.1097/00004872-200409000-00023 ◽

2004 ◽

Vol 22 (9) ◽

pp. 1779-1785 ◽

Cited By ~ 33

Author(s):

Michael L Tuck ◽

Farida Bounoua ◽

Pirooz Eslami ◽

Michael D Nyby ◽

Peter Eggena ◽

...

Keyword(s):

Smooth Muscle ◽

Angiotensin Ii ◽

Protein Kinase ◽

Vascular Smooth Muscle ◽

Smooth Muscle Cells ◽

Vascular Smooth Muscle Cells ◽

Muscle Cells ◽

Mitogen Activated Protein Kinase ◽

Mitogen Activated Protein ◽

Kinase Pathway

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Vascular smooth muscle cells grown on Matrigel. A model of the contractile phenotype with decreased activation of mitogen-activated protein kinase.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(17)32219-6 ◽

1994 ◽

Vol 269 (30) ◽

pp. 19653-19658

Author(s):

X. Li ◽

P. Tsai ◽

E.D. Wieder ◽

A. Kribben ◽

V. Van Putten ◽

...

Keyword(s):

Smooth Muscle ◽

Protein Kinase ◽

Vascular Smooth Muscle ◽

Smooth Muscle Cells ◽

Vascular Smooth Muscle Cells ◽

Muscle Cells ◽

Mitogen Activated Protein Kinase ◽

Contractile Phenotype ◽

Mitogen Activated Protein

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Direct evidence for tyrosine and threonine phosphorylation and activation of mitogen-activated protein kinase by vasopressin in cultured rat vascular smooth muscle cells

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)98388-2 ◽

1993 ◽

Vol 268 (13) ◽

pp. 9564-9569

Author(s):

Y. Granot ◽

E. Erikson ◽

H. Fridman ◽

V. Van Putten ◽

B. Williams ◽

...

Keyword(s):

Smooth Muscle ◽

Protein Kinase ◽

Vascular Smooth Muscle ◽

Smooth Muscle Cells ◽

Vascular Smooth Muscle Cells ◽

Direct Evidence ◽

Muscle Cells ◽

Mitogen Activated Protein Kinase ◽

Mitogen Activated Protein

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The p38 mitogen-activated protein kinase is involved in stress-induced phospholipase D activation in vascular smooth muscle cells

Experimental & Molecular Medicine ◽

10.1038/emm.2002.6 ◽

2002 ◽

Vol 34 (1) ◽

pp. 38-46 ◽

Cited By ~ 9

Author(s):

Do Sik Min ◽

Eun-Young Shin ◽

Eung-Gook Kim

Keyword(s):

Smooth Muscle ◽

Protein Kinase ◽

Vascular Smooth Muscle ◽

Smooth Muscle Cells ◽

Vascular Smooth Muscle Cells ◽

Phospholipase D ◽

Muscle Cells ◽

Mitogen Activated Protein Kinase ◽

Mitogen Activated Protein

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Ceramide-dependent regulation of p42/p44 mitogen-activated protein kinase and c-Jun N-terminal-directed protein kinase in cultured airway smooth muscle cells

Cellular Signalling ◽

10.1016/s0898-6568(00)00119-4 ◽

2000 ◽

Vol 12 (11-12) ◽

pp. 737-743 ◽

Cited By ~ 19

Author(s):

A CONWAY

Keyword(s):

Smooth Muscle ◽

Protein Kinase ◽

Smooth Muscle Cells ◽

Airway Smooth Muscle ◽

Muscle Cells ◽

Mitogen Activated Protein Kinase ◽

Airway Smooth Muscle Cells ◽

Mitogen Activated Protein

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Diverse Effects of Heparin on Mitogen-Activated Protein Kinase–Dependent Signal Transduction in Vascular Smooth Muscle Cells

Circulation Research ◽

10.1161/01.res.81.1.17 ◽

1997 ◽

Vol 81 (1) ◽

pp. 17-23 ◽

Cited By ~ 38

Author(s):

Günter Daum ◽

Ulf Hedin ◽

Yunxia Wang ◽

Trevina Wang ◽

Alexander W. Clowes

Keyword(s):

Signal Transduction ◽

Smooth Muscle ◽

Protein Kinase ◽

Vascular Smooth Muscle ◽

Smooth Muscle Cells ◽

Vascular Smooth Muscle Cells ◽

Muscle Cells ◽

Mitogen Activated Protein Kinase ◽

Mitogen Activated Protein ◽

Dependent Signal

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Protein kinase C-delta negatively regulates migration and proliferation of vascular smooth muscle cells through inhibition of the mitogen activated protein kinase ERK1/2

Journal of Surgical Research ◽

10.1016/j.jss.2005.11.062 ◽

2006 ◽

Vol 130 (2) ◽

pp. 182-183

Author(s):

E. Ryer ◽

B. Liu ◽

R. Hom ◽

K. Sakakibara ◽

S. Trocciola ◽

...

Keyword(s):

Smooth Muscle ◽

Protein Kinase C ◽

Protein Kinase ◽

Vascular Smooth Muscle ◽

Smooth Muscle Cells ◽

Vascular Smooth Muscle Cells ◽

Muscle Cells ◽

Mitogen Activated Protein Kinase ◽

Kinase C ◽

Mitogen Activated Protein

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Interleukin-1β enhances bradykinin-induced phosphoinositide hydrolysis and Ca2+ mobilization in canine tracheal smooth-muscle cells: involvement of the Ras/Raf/mitogen-activated protein kinase (MAPK) kinase (MEK)/MAPK pathway

Biochemical Journal ◽

10.1042/0264-6021:3540439 ◽

2001 ◽

Vol 354 (2) ◽

pp. 439 ◽

Cited By ~ 14

Author(s):

Chuen-Mao YANG ◽

Chin-Sung CHIEN ◽

Chuan-Chwan WANG ◽

Yan-Mei HSU ◽

Chi-Tso CHIU ◽

...

Keyword(s):

Smooth Muscle ◽

Protein Kinase ◽

Smooth Muscle Cells ◽

Mapk Pathway ◽

Muscle Cells ◽

Mitogen Activated Protein Kinase ◽

Interleukin 1Β ◽

Tracheal Smooth Muscle ◽

Mapk Kinase ◽

Mitogen Activated Protein

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Induction of cyclooxygenase-2 expression in human myometrial smooth muscle cells by interleukin-1β: involvement of p38 mitogen-activated protein kinase

The Journal of Physiology ◽

10.1111/j.1469-7793.1999.00399.x ◽

1999 ◽

Vol 520 (2) ◽

pp. 399-406 ◽

Cited By ~ 80

Author(s):

Simon R. Bartlett ◽

Robert Sawdy ◽

Giovanni E. Mann

Keyword(s):

Smooth Muscle ◽

Protein Kinase ◽

Smooth Muscle Cells ◽

Muscle Cells ◽

Cyclooxygenase 2 ◽

Mitogen Activated Protein Kinase ◽

Interleukin 1Β ◽

Mitogen Activated Protein

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Induction of Smooth Muscle α-Actin in Vascular Smooth Muscle Cells by Arginine Vasopressin Is Mediated by c-Jun Amino-terminal Kinases and p38 Mitogen-activated Protein Kinase

Journal of Biological Chemistry ◽

10.1074/jbc.m003000200 ◽

2000 ◽

Vol 275 (29) ◽

pp. 22537-22543 ◽

Cited By ~ 40

Author(s):

Chrystelle Garat ◽

Vicki Van Putten ◽

Zaki A. Refaat ◽

Christina Dessev ◽

Sun-Young Han ◽

...

Keyword(s):

Smooth Muscle ◽

Protein Kinase ◽

Vascular Smooth Muscle ◽

Smooth Muscle Cells ◽

Vascular Smooth Muscle Cells ◽

Arginine Vasopressin ◽

Muscle Cells ◽

Mitogen Activated Protein Kinase ◽

Amino Terminal ◽

Mitogen Activated Protein

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