scholarly journals cGMP-stimulated cyclic nucleotide phosphodiesterase regulates the basal calcium current in human atrial myocytes.

1997 ◽  
Vol 99 (11) ◽  
pp. 2710-2718 ◽  
Author(s):  
M Rivet-Bastide ◽  
G Vandecasteele ◽  
S Hatem ◽  
I Verde ◽  
A Bénardeau ◽  
...  
Keyword(s):  
Cyclic Nucleotide ◽  
Calcium Current ◽  
Cyclic Nucleotide Phosphodiesterase ◽  
Atrial Myocytes ◽  
Human Atrial Myocytes

scholarly journals L-type calcium current in pediatric and adult human atrial myocytes

1996 ◽  
Vol 27 (2) ◽  
pp. 96
Author(s):  
Theresa P. Roca ◽  
John D. Pigott ◽  
Craig W. Clarkson ◽  
Arthur S. Pickoff ◽  
William J. Crumb
Keyword(s):  
Calcium Current ◽  
Atrial Myocytes ◽  
Human Atrial Myocytes ◽  
Adult Human

scholarly journals Nitric oxide regulates the calcium current in isolated human atrial myocytes.

1995 ◽  
Vol 95 (2) ◽  
pp. 794-802 ◽  
Author(s):  
M Kirstein ◽  
M Rivet-Bastide ◽  
S Hatem ◽  
A Bénardeau ◽  
J J Mercadier ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Calcium Current ◽  
Atrial Myocytes ◽  
Human Atrial Myocytes

Chronic Atrial Fibrillation Increases MicroRNA-21 in Human Atrial Myocytes Decreasing L-Type Calcium Current

2014 ◽  
Vol 7 (5) ◽  
pp. 861-868 ◽  
Author(s):  
Adriana Barana ◽  
Marcos Matamoros ◽  
Pablo Dolz-Gaitón ◽  
Marta Pérez-Hernández ◽  
Irene Amorós ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Calcium Current ◽  
Chronic Atrial Fibrillation ◽  
Atrial Myocytes ◽  
Human Atrial Myocytes

Adenosine inhibits the L-type calcium current in human atrial myocytes

1995 ◽  
Vol 351 (3) ◽  
Author(s):  
Brigitte Pelzmann ◽  
Peter Schaffer ◽  
Heinrich M�chler ◽  
Bruno Rigler ◽  
Bernd Koidl
Keyword(s):  
Calcium Current ◽  
Atrial Myocytes ◽  
Human Atrial Myocytes

Developmental differences in L-type calcium current of human atrial myocytes

2004 ◽  
Vol 286 (5) ◽  
pp. H1963-H1969 ◽  
Author(s):  
Srinivas M. Tipparaju ◽  
Rajiv Kumar ◽  
Yanggan Wang ◽  
Ronald W. Joyner ◽  
Mary B. Wagner
Keyword(s):  
Older Adult ◽  
Calcium Current ◽  
Low Dose ◽  
Developmental Differences ◽  
Right Atrial ◽  
Atrial Myocytes ◽  
Adrenergic Stimulation ◽  
Inhibitory Effects ◽  
Human Atrial Myocytes ◽  
Protein Levels

We investigated differences in L-type Ca2+ current ( ICa) between infant (INF, 1–12 mo old), young adult (YAD, 14–18 yr old), and older adult (AD) myocytes from biopsies of right atrial appendages. Basal ICa was smaller in INF myocytes (1.2 ± 0.1 pA/pF, n = 29, 6 ± 1 mo old, 11 patients) than in YAD (2.5 ± 0.2 pA/pF, n = 20, 16 ± 1 yr old, 5 patients) or AD (2.6 ± 0.3 pA/pF, n = 19, 66 ± 3 yr old, 9 patients) myocytes ( P < 0.05). Maximal ICa produced by isoproterenol (Iso) was similar in INF, YAD, and AD cells: 8.4 ± 1.1, 9.6 ± 1.0, and 9.2 ± 1.3 pA/pF, respectively. Efficacy (Emax) was larger in INF (607 ± 50%) than for YAD (371 ± 29%) or AD (455 ± 12%) myocytes. Potency (EC50) was 8- to 10-fold higher in AD (0.82 ± 0.09 nM) or YAD (0.41 ± 0.14 nM) than in INF (7.6 ± 3.5 nM) myocytes. Protein levels were similar for Giα2 but much greater for Giα3 in INF than in AD or YAD atrial tissue. When Giα3 activity was inhibited by inclusion of a Giα3 COOH-terminal decapeptide in the pipette, basal ICa and the response to 10 nM Iso were increased in INF, but not in YAD, cells. We propose that basal ICa and the response to low-dose β-adrenergic stimulation are inhibited in INF (but not YAD or AD) cells as a result of constitutive inhibitory effects of Giα3.

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