scholarly journals Development of experimental model of chronic pyelonephritis with Escherichia coli O75:K5:H-bearing Dr fimbriae: mutation in the dra region prevented tubulointerstitial nephritis.

1997 ◽  
Vol 99 (7) ◽  
pp. 1662-1672 ◽  
Author(s):  
P Goluszko ◽  
S L Moseley ◽  
L D Truong ◽  
A Kaul ◽  
J R Williford ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Experimental Model ◽  
Tubulointerstitial Nephritis ◽  
Chronic Pyelonephritis

scholarly journals Efficacy of Ciprofloxacin in an Experimental Model of Escherichia coli Chorioamnionitis in Rabbits

2009 ◽  
Vol 53 (4) ◽  
pp. 1624-1627 ◽  
Author(s):  
Elise Launay ◽  
Nicolas Joram ◽  
Cédric Jacqueline ◽  
Anne Francoise Miegeville ◽  
Jocelyne Caillon ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Survival Rate ◽  
Experimental Model ◽  
Resistant Mutants ◽  
Selection Of

ABSTRACT Pregnant rabbits were treated with ciprofloxacin alone or with gentamicin in a model of Escherichia coli chorioamnionitis, and the results were compared with those for untreated rabbits. The survival rate increased and the bacteremia decreased significantly in treated fetuses in comparison to controls (P = 0.003). Nevertheless, rapid selection of resistant mutants is a major limit to ciprofloxacin applications.

scholarly journals Assessment of bacterial translocation in obstructive jaundice using Tc-99m Escherichia coli

2005 ◽  
Vol 48 (spe2) ◽  
pp. 45-49 ◽  
Author(s):  
Simone Odília Fernandes Diniz ◽  
Alfredo José Afonso Barbosa ◽  
Ivana Durval Araújo ◽  
David Lee Nelson ◽  
Leonardo Augusto da Silva Machado ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Renal Failure ◽  
Bile Duct ◽  
Obstructive Jaundice ◽  
Experimental Model ◽  
Bacterial Translocation ◽  
Histological Analysis ◽  
Systemic Circulation ◽  
Intestinal Wall ◽  
Pulmonary Dysfunction

In obstructive jaundice, the passage of bacteria and endotoxins through the intestine wall to reach the systemic circulation is associated with septicemia, renal failure and pulmonary dysfunction. The aim of this work was to investigate bacterial translocation utilizing 99mTc-E.coli in an experimental model of obstructive jaundice. The levels of bilirubin in rats that were subjected to ligature of the bile duct were significantly increased when compared to control animals (p < 0.001). The biodistribution results did not show any translocation of 99mTc-E.coli to the mesenteric lymphatic nodules, liver, spleen or lungs of the rats that suffered ligature of the bile duct (p > 0.05). The evaluation of the intestinal permeability using "per os" administration of 99mTc-DTPA showed 1.61 ± 0.57% and 1.39 ± 0.72% of radioactivity in the urine of the control and jaundice animals, respectively. The histological analysis of the distal wall of the ileum showed that the covering epithelium and the crypt were morphologically preserved in both groups. The seven-day period after the ligature of the bile duct may not have been long enough to promote modifications in intestinal wall to occur so as to permit the passage of Tc-99m E.coli.

scholarly journals Efficacy of amoxycillin–clavulanate in an experimental model of murine pneumonia caused by AmpC-non-hyperproducing clinical isolates of Escherichia coli resistant to cefoxitin

2008 ◽  
Vol 14 (6) ◽  
pp. 582-587 ◽  
Author(s):  
F. Docobo-Pérez ◽  
F. Fernández-Cuenca ◽  
M.E. Pachón-Ibáñez ◽  
A. Pascual ◽  
C. Pichardo ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Experimental Model ◽  
Clinical Isolates
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