scholarly journals Interleukin 6 causes growth impairment in transgenic mice through a decrease in insulin-like growth factor-I. A model for stunted growth in children with chronic inflammation.

1997 ◽  
Vol 99 (4) ◽  
pp. 643-650 ◽  
Author(s):  
F De Benedetti ◽  
T Alonzi ◽  
A Moretta ◽  
D Lazzaro ◽  
P Costa ◽  
...  
Keyword(s):  
Growth Factor ◽  
Transgenic Mice ◽  
Chronic Inflammation ◽  
Interleukin 6 ◽  
Insulin Like Growth Factor ◽  
Stunted Growth ◽  
Growth Impairment ◽  
Factor I ◽  
Growth Factor I

Insulin-like growth factor-I overexpression in the testes of transgenic mice

1999 ◽  
Vol 51 (1) ◽  
pp. 419 ◽  
Author(s):  
M.K Dyck ◽  
M Ouellet ◽  
M Gagné ◽  
F Pothier
Keyword(s):  
Growth Factor ◽  
Transgenic Mice ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Growth Factor I

Receptor synergy of interleukin-6 (IL-6) and insulin-like growth factor-I in myeloma cells that highly express IL-6 receptor α

Blood ◽  
2004 ◽  
Vol 103 (6) ◽  
pp. 2291-2298 ◽  
Author(s):  
Saeid Abroun ◽  
Hideaki Ishikawa ◽  
Naohiro Tsuyama ◽  
Shangqin Liu ◽  
Fu-Jun Li ◽  
...  
Keyword(s):  
Growth Factor ◽  
Cell Line ◽  
Interleukin 6 ◽  
Janus Kinase ◽  
Insulin Like Growth Factor ◽  
Myeloma Cells ◽  
Factor I ◽  
Igf I ◽  
Growth Factor I ◽  
Human Myeloma Cells

Abstract Interleukin-6 (IL-6) is a growth and antiapoptotic factor for human myeloma cells. The autocrine loop and increased expression of the growth factor receptors have been postulated as the mechanisms of tumorigenesis. Here we show that IL-6 stimulation induced the phosphorylation of insulin-like growth factor-I (IGF-I) receptors in a human myeloma cell line, NOP2, highly expressing IL-6 receptor α (IL-6Rα) and in the IL-6Rα–transfected U266 cell line. IL-6–dependent complex formation of IL-6Rα with IGF-I receptor β was found in NOP2 where IL-6Rα colocalized with IGF-I receptors at lipid rafts. Moreover, the IL-6–induced phosphorylation of IGF-I receptor β was not blocked by a Janus kinase 2 (Jak2) inhibitor. In addition to the activation of the signal transducer and activator of transcription 3 and extracellular signal-regulated kinase 1/2, IL-6 stimulation led to the activation of Akt, presumably following the phosphorylation of IGF-I receptors. Thus, our results suggest that in NOP2, IL-6Rα and IGF-I receptors exist on the plasma membrane in close proximity, facilitating the efficient assembly of 2 receptors in response to IL-6. The synergistic effects of highly expressed IL-6Rα on IGF-I receptor–mediated signals provide a novel insight into the Jak-independent IL-6 signaling mechanism of receptor cross-talk in human myeloma cells.

Expression of Insulin-Like Growth Factor I Stimulates Normal Somatic Growth in Growth Hormone-Deficient Transgenic Mice

Endocrinology ◽  
1990 ◽  
Vol 127 (3) ◽  
pp. 1033-1040 ◽  
Author(s):  
RICHARD R. BEHRINGER ◽  
TAL M. LEWIN ◽  
CAROL J. QUAIFE ◽  
RICHARD D. PALMITER ◽  
RALPH L. BRINSTER ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Factor ◽  
Transgenic Mice ◽  
Somatic Growth ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Growth Factor I

Testes-specific transgene expression in insulin-like growth factor-I transgenic mice

1999 ◽  
Vol 54 (1) ◽  
pp. 32-42 ◽  
Author(s):  
Michael K. Dyck ◽  
Mariette Ouellet ◽  
Marc Gagn� ◽  
Denis Petitclerc ◽  
Marc-Andr� Sirard ◽  
...  
Keyword(s):  
Growth Factor ◽  
Transgenic Mice ◽  
Transgene Expression ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Growth Factor I

Transgenic mice with osteoblast-targeted insulin-like growth factor-I show increased bone remodeling

Bone ◽  
2006 ◽  
Vol 39 (3) ◽  
pp. 494-504 ◽  
Author(s):  
Jin Jiang ◽  
Alexander C. Lichtler ◽  
Gloria A. Gronowicz ◽  
Douglas J. Adams ◽  
Stephen H. Clark ◽  
...  
Keyword(s):  
Growth Factor ◽  
Transgenic Mice ◽  
Bone Remodeling ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Growth Factor I
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