scholarly journals Genetic isolation of a region of chromosome 8 that exerts major effects on blood pressure and cardiac mass in the spontaneously hypertensive rat.

1997 ◽  
Vol 99 (4) ◽  
pp. 577-581 ◽  
Author(s):  
V Kren ◽  
M Pravenec ◽  
S Lu ◽  
D Krenova ◽  
J M Wang ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Spontaneously Hypertensive Rat ◽  
Cardiac Mass ◽  
Chromosome 8 ◽  
Genetic Isolation ◽  
Spontaneously Hypertensive ◽  
Hypertensive Rat

Genetic isolation of a blood pressure quantitative trait locus on chromosome 2 in the spontaneously hypertensive rat

2001 ◽  
Vol 19 (6) ◽  
pp. 1061-1064 ◽  
Author(s):  
Michal Pravenec ◽  
Václav Zídek ◽  
Alena Musilová ◽  
Jaroslav Vorlícuek ◽  
Vladimír Kruen ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Quantitative Trait Locus ◽  
Quantitative Trait ◽  
Spontaneously Hypertensive Rat ◽  
Chromosome 2 ◽  
Genetic Isolation ◽  
Spontaneously Hypertensive ◽  
Hypertensive Rat ◽  
Trait Locus

Genetic Isolation of a Chromosome 1 Region Affecting Blood Pressure in the Spontaneously Hypertensive Rat

Hypertension ◽  
1997 ◽  
Vol 30 (4) ◽  
pp. 854-858 ◽  
Author(s):  
Elizabeth St. Lezin ◽  
Weizhong Liu ◽  
Jia-Ming Wang ◽  
Ning Wang ◽  
Vladimir Kren ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Spontaneously Hypertensive Rat ◽  
Chromosome 1 ◽  
Genetic Isolation ◽  
Spontaneously Hypertensive ◽  
Hypertensive Rat

Hypoxic moderation of systemic hypertension in the spontaneously hypertensive rat

1987 ◽  
Vol 252 (3) ◽  
pp. R554-R561 ◽  
Author(s):  
W. N. Henley ◽  
A. Tucker
Keyword(s):  
Blood Pressure ◽  
Spontaneously Hypertensive Rat ◽  
Metabolic Adaptation ◽  
Systemic Hypertension ◽  
Thyroid Status ◽  
Blood Pressure Elevation ◽  
Spontaneously Hypertensive ◽  
Moderate Hypobaric Hypoxia ◽  
Hypertensive Rat ◽  
Wistar Kyoto

The mechanism by which chronic, moderate, hypobaric hypoxia attenuates systemic systolic blood pressure (SBP) in the spontaneously hypertensive rat (SHR) was investigated in a three-part study. In experiment 1, 10 wk of hypoxia (3,658 m altitude) commencing in 7-wk-old rats was partially effective in preventing the rise in SBP [hypoxic SHR (SHR-H) 154 mmHg vs. normoxic SHR (SHR-N) 180 mmHg; P less than 0.01]. When hypoxia was initiated in 5-wk-old SHR (experiments 2 and 3), protection against hypertension was nearly complete (experiment 2: SHR-H 122 mmHg vs. SHR-N 175 mmHg; P less than 0.001; experiment 3: 135 vs. 152 mmHg, respectively; P less than 0.05). Elevations in O2 consumption (VO2) and rectal temperature (Tre) in SHR vs. normotensive [Wistar-Kyoto (WKY)] rats provided evidence that the SHR is a hypermetabolic animal. Thyroid hormonal indices suggested that SHR changed from a low to high thyroid status at a time that rapid blood pressure elevation occurred; however, hypoxia did not influence thyroid status. Acute, significant decrements in VO2 and Tre in SHR-H (experiments 2 and 3) accompanied the attenuation of SBP by hypoxia, whereas large decrements in VO2 and SBP did not occur in hypoxic WKY. Timely administration of moderate hypoxia protects against the development of hypertension in the SHR. This protection may relate to a metabolic adaptation made by the hypoxic SHR.

Sodium–Proton (Na+/H+) Exchange Inhibition Increases Blood Pressure in Spontaneously Hypertensive Rat

1994 ◽  
Vol 308 (3) ◽  
pp. 145-151 ◽  
Author(s):  
Yiu-Fai Chen ◽  
Ren-Hui Yang ◽  
Qing-Cheng Meng ◽  
Edward J. Cragoe ◽  
Suzanne Oparil
Keyword(s):  
Blood Pressure ◽  
Spontaneously Hypertensive Rat ◽  
Spontaneously Hypertensive ◽  
Hypertensive Rat
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