scholarly journals The relationship between the fibrinogen D domain self-association/cross-linking site (gammaXL) and the fibrinogen Dusart abnormality (Aalpha R554C-albumin): clues to thrombophilia in the "Dusart syndrome".

1996 ◽  
Vol 97 (10) ◽  
pp. 2342-2350 ◽  
Author(s):  
M W Mosesson ◽  
K R Siebenlist ◽  
J f Hainfeld ◽  
J S Wall ◽  
J Soria ◽  
...  
Keyword(s):  
Cross Linking ◽  
Self Association ◽  
The Relationship

scholarly journals Unveiling the self-association and desolvation in crystal nucleation

IUCrJ ◽  
2021 ◽  
Vol 8 (3) ◽  
pp. 468-479
Author(s):  
Danning Li ◽  
Yongli Wang ◽  
Shuyi Zong ◽  
Na Wang ◽  
Xin Li ◽  
...  
Keyword(s):  
Density Functional ◽  
Interaction Strength ◽  
Solution Chemistry ◽  
The Self ◽  
Crystal Nucleation ◽  
Nucleation Kinetics ◽  
Molecular Conformations ◽  
Self Association ◽  
Induction Times ◽  
The Relationship

As the first step in the crystallization process, nucleation has been studied by many researchers. In this work, phenacetin (PHEN) was selected as a model compound to investigate the relationship between the solvent and nucleation kinetics. Induction times at different supersaturation in six solvents were measured. FTIR and NMR spectroscopy were employed to explore the solvent–solute interactions and the self-association properties in solution. Density functional theory (DFT) was adopted to evaluate the strength of solute–solvent interactions and the molecular conformations in different solvents. Based on these spectroscopy data, molecular simulation and nucleation kinetic results, a comprehensive understanding of the relationship between molecular structure, crystal structure, solution chemistry and nucleation dynamics is discussed. Both the solute–solvent interaction strength and the supramolecular structure formed by the self-association of solute molecules affect the nucleation rate. The findings reported here shed new light on the molecular mechanism of nucleation in solution.

scholarly journals A gamma Gly-268 to Glu substitution is responsible for impaired fibrin assembly in a homozygous dysfibrinogen Kurashiki I

Blood ◽  
1996 ◽  
Vol 87 (11) ◽  
pp. 4686-4694 ◽  
Author(s):  
K Niwa ◽  
M Takebe ◽  
T Sugo ◽  
Y Kawata ◽  
J Mimuro ◽  
...  
Keyword(s):  
Tissue Type ◽  
Factor Xiiia ◽  
Cross Linking ◽  
Fibrin Gel ◽  
Functional Abnormality ◽  
Human Fibrinogen ◽  
Fibrin Monomer ◽  
Longitudinal Association ◽  
Self Association ◽  
A Site

A new type of gamma Gly-268 (GGA) to Glu (GAA) substitution has been identified in a homozygous dysfibrinogen by analyses of the affected polypeptide and its encoding gene derived from a 58 year-old man manifesting no major bleeding or thrombosis. The functional abnormality was characterized by impaired fibrin assembly most likely due to failure to construct properly aligned double-stranded fibrin protofibrils. This presumption was deduced from the following findings: (1) Factor XIIIa-catalyzed cross-linking of the fibrin gamma-chains progressed in a normal fashion, indicating that the contact between the central E domain of one fibrin monomer and the D domain of another took place normally; (2) Nevertheless, factor XIIIa-catalyzed cross-linking of the fibrinogen gamma-chains was obviously delayed, suggesting that longitudinal association of D domains of different fibrin monomers, ie, D:D association was perturbed; (3) Plasminogen activation catalyzed by tissue-type plasminogen activator was not as efficiently facilitated by polymerizing fibrin monomer derived from the patient as by the normal counterpart. Therefore, gamma Gly-268 would not be involved in the 'a' site residing in the D domain, which functions as a complementary binding site with the thrombin-activated 'A' site in the central E domain, but would be rather involved in the D:D self association sites recently proposed for human fibrinogen. Thus, the gamma Glu-268 substitution newly identified in this homozygous dysfibrinogen seems to impair proper alignment of adjacent D domains of neighboring fibrin molecules in the double-stranded fibrin protofibril, resulting in delayed fibrin gel formation.

Distinct Steps of Cross-linking, Self-association, and Maturation of Tropoelastin Are Necessary for Elastic Fiber Formation

2007 ◽  
Vol 369 (3) ◽  
pp. 841-851 ◽  
Author(s):  
Fumiaki Sato ◽  
Hiroshi Wachi ◽  
Marie Ishida ◽  
Risa Nonaka ◽  
Satoshi Onoue ◽  
...  
Keyword(s):  
Elastic Fiber ◽  
Fiber Formation ◽  
Cross Linking ◽  
Self Association

The relationship between collagen scaffold cross-linking agents and neutrophils in the foreign body reaction

Biomaterials ◽  
2010 ◽  
Vol 31 (35) ◽  
pp. 9192-9201 ◽  
Author(s):  
Qingsong Ye ◽  
Martin C. Harmsen ◽  
Marja J.A. van Luyn ◽  
Ruud A. Bank
Keyword(s):  
Foreign Body ◽  
Foreign Body Reaction ◽  
Collagen Scaffold ◽  
Cross Linking ◽  
The Relationship

Research of Electrochemistry Measuring System Based on Saliva Glucose

2011 ◽  
Vol 301-303 ◽  
pp. 1139-1144
Author(s):  
Li Ying Jiang ◽  
Li Jie Ren ◽  
Qing Hua Chen ◽  
Guang Zhao Cui
Keyword(s):  
Glucose Oxidase ◽  
Chemical Sensors ◽  
Linear Relation ◽  
Glucose Solution ◽  
Solution Concentration ◽  
Measuring System ◽  
Cross Linking ◽  
Glucose Content ◽  
Relationship Of ◽  
The Relationship

According to the relationship of glucose content in diabetes saliva and blood, the biosensor for detecting saliva glucose was introduced based on electrochemical detecting principle, glucose oxidase was immobilized onto the surface of electrode by glutaraldehyde cross-linking. The measuring system was designed by using potentiostat for amperometric chemical sensors. The characters of the microsystem has been demonstrated with the detection of standard glucose solution concentration of saliva parameter. Compared with the data obtained from the instrument CHI660A, it showed that has a good linear relation in the linear range of 0-2200µmol/L, with the correlation coefficient of 0.9531.

Binding of pp60v-src to membranes: evidence for multiple membrane interactions

1992 ◽  
Vol 70 (10-11) ◽  
pp. 1187-1192 ◽  
Author(s):  
Lauren Silverman ◽  
Catherine T. Sigal ◽  
Marilyn D. Resh
Keyword(s):  
Membrane Binding ◽  
Cross Linking ◽  
Binding Characteristics ◽  
Binding Domains ◽  
Rous Sarcoma ◽  
Subcellular Membrane ◽  
Sarcoma Virus ◽  
The Relationship

Membrane association of pp60v-src, the myristylated transforming protein of Rous sarcoma virus, has been shown to be a receptor-mediated process, which is inhibited by myristylated src peptides containing the N-terminal 11 amino acids of the v-src sequence (MGYsrc). By cross-linking radiolabeled MGYsrc peptide to fibroblast membranes, a 32-kilodalton membrane protein was identified as a candidate src receptor. To elucidate the potential role of p32 in binding pp60v-src, we studied the relationship between binding of MGYsrc peptide and pp60v-src polypeptide to cellular membranes. The subcellular membrane distribution of p32 was distinct from that of pp60v-src in transformed cells. Moreover, under certain defined in vitro conditions, it was possible to inhibit peptide cross-linking to p32 without significantly affecting pp60v-src membrane binding. However, when internal sequences were removed from pp60v-src, the binding characteristics of the src deletion polypeptide and MGYsrc peptide became identical. These data indicate that the presence of internal membrane binding domains influences the interaction of myristylated N-terminal src sequences with p32, and suggest that accessory binding factors might be involved in establishing stable contact between pp60v-src and the membrane phospholipid bilayer.Key words: myristylation, pp60v-src, membrane binding, cross-linking.

Changes in the Molecular Structure of UHMW Polyethylene under the Influence of Thermal and Radiation Modification, as Well as Time

2013 ◽  
Vol 197 ◽  
pp. 19-24 ◽  
Author(s):  
Joanna Maszybrocka ◽  
Piotr Czaja ◽  
Jerzy Cybo ◽  
Jacek Michniowski ◽  
Adrian Barylski
Keyword(s):  
Molecular Structure ◽  
Atmospheric Oxygen ◽  
Absorbed Dose ◽  
Cross Linking ◽  
Highly Active ◽  
Degree Of Oxidation ◽  
Order Of Magnitude ◽  
Radiation Modification ◽  
The Relationship ◽  
Over Time

The paper presents the results of an examination of UHMW polyethylene type GUR1050 using the EPR, FTIR and SEM methods. The relationship between the number of radicals in the polymer and the absorbed dose of ionizing radiation has been shown. The radicals, being highly active macroparticles, disappear in time, so that after about a year their amount is reduced by approximately one order of magnitude. The disappearance of the radicals over time results in a change in EPR spectra, an increase in the degree of oxidation, and cross-linking. The most probable mechanisms are the formation of alkyl and allyl radicals and their gradual transitions, which lead to the absorption of atmospheric oxygen, and the recombination of radicals, which leads to the formation of cross linkages. Thermal treatment of the samples is an effective method of eliminating the radicals. Tribological tests and their analysis by means of SEM observation showed that the irradiated samples proved to have higher resistance to abrasion than the material that was not exposed to radiation.

Modulus of Plasticized Ionic Rubbers

1972 ◽  
Vol 45 (4) ◽  
pp. 908-917
Author(s):  
A. Eisenberg ◽  
M. King
Keyword(s):  
Dielectric Constant ◽  
Acrylic Acid ◽  
Vinyl Alcohol ◽  
High Dielectric Constant ◽  
Poly Vinyl Alcohol ◽  
Cross Linking ◽  
Two Component ◽  
High Dielectric ◽  
The Relationship ◽  
Ionic Forms

Abstract The rubbery modulus of a crosslinked ionizable rubber is explored in the absence of the crosslinking effect of ions, that is, only through the effect of ions on conformation. The crosslinking effect is eliminated by plasticizing the rubber with a liquid of high dielectric constant. Experimentally, a rubber is prepared by mixing poly (acrylic acid) and poly (vinyl alcohol) and cross-linking thermally. The relationship between the rubbery moduli of the unionized and the ionized forms of the plasticized material is studied. A theory for the modulus of such a two-component rubber is derived and the predictions are compared with experiment. It is shown that the predicted ratio of the moduli in the acidic and ionic forms is in the same direction as determined experimentally, but that the calculation underestimates the magnitude of the effect. Several reasons for this discrepancy are given.

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