scholarly journals Islet transplantation under the kidney capsule fully corrects the impaired skeletal muscle glucose transport system of streptozocin diabetic rats.

1996 ◽  
Vol 97 (6) ◽  
pp. 1389-1397 ◽  
Author(s):  
R Napoli ◽  
A M Davalli ◽  
M F Hirshman ◽  
R Weitgasser ◽  
G C Weir ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Glucose Transport ◽  
Islet Transplantation ◽  
Transport System ◽  
Diabetic Rats ◽  
Kidney Capsule ◽  
Glucose Transport System ◽  
Muscle Glucose Transport

Effects of maturation and aging on the skeletal muscle glucose transport system

1992 ◽  
Vol 262 (5) ◽  
pp. E619-E626 ◽  
Author(s):  
R. J. Barnard ◽  
L. O. Lawani ◽  
D. A. Martin ◽  
J. F. Youngren ◽  
R. Singh ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Glucose Transport ◽  
Kinase Activity ◽  
Age Groups ◽  
Insulin Receptors ◽  
Glucose Transporters ◽  
Glucose Transport System ◽  
Significant Difference ◽  
Old Rats ◽  
Muscle Glucose Transport

Insulin resistance in old, compared with young, humans and animals has been well documented. The resistance is due primarily to defects in skeletal muscle. In the present study, skeletal muscle sarcolemmal membranes were purified from five age groups of female Fischer rats ranging from 2 to 24 mo. Basal specific D-glucose transport was not significantly different among any of the groups. Maximum insulin-stimulated transport was progressively decreased from 96.4 +/- 5.0 pmol.mg-1.15 s-1 in the 2-mo-old animals to 70.8 +/- 8.9 pmol.mg-1.15 s-1 in the 24-mo-old animals. Most of the decrease occurred during maturation, and in fact there was no significant difference in maximum transport among the 8-, 16-, and 24-mo-old rats. The decrease in insulin-stimulated transport in the 24-mo-old animals was due to a reduction in the number of glucose transporters translocated into the sarcolemma membrane (9.8 +/- 0.6 vs. 7.8 +/- 0.6 pmol/mg protein). The intracellular or microsomal pool of glucose transporters was not significantly different between the 2- and 24-mo-old animals (8.8 +/- 0.6 vs. 8.5 +/- 0.9/mg protein). Western blotting revealed no differences in the cellular GLUT-4 contents between the 2- and 24-mo-old rats. The number of insulin receptors (2.3 +/- 0.4 vs. 2.1 +/- 0.5 pmol/mg protein) was not significantly different. Tyrosine kinase activity of the insulin receptor was, however, significantly reduced in the 24-mo-old compared with the 2-mo-old animals.(ABSTRACT TRUNCATED AT 250 WORDS)

scholarly journals In vitro analysis of the glucose-transport system in GLUT4-null skeletal muscle

1999 ◽  
Vol 342 (2) ◽  
pp. 321 ◽  
Author(s):  
Jeffrey W. RYDER ◽  
Yuichi KAWANO ◽  
Alexander V. CHIBALIN ◽  
Jorge RINCÓN ◽  
Tsu-Shuen TSAO ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Glucose Transport ◽  
Transport System ◽  
Glucose Transport System ◽  
Vitro Analysis ◽  
In Vitro Analysis
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