scholarly journals Characterization of a glomerular epithelial cell metalloproteinase as matrix metalloproteinase-9 with enhanced expression in a model of membranous nephropathy.

1996 ◽  
Vol 97 (4) ◽  
pp. 1094-1101 ◽  
Author(s):  
J I McMillan ◽  
J W Riordan ◽  
W G Couser ◽  
A S Pollock ◽  
D H Lovett
Keyword(s):  
Epithelial Cell ◽  
Matrix Metalloproteinase ◽  
Membranous Nephropathy ◽  
Matrix Metalloproteinase 9 ◽  
Glomerular Epithelial Cell ◽  
Enhanced Expression ◽  
Metalloproteinase 9

scholarly journals Characterization of the Monomeric and Dimeric Forms of Latent and Active Matrix Metalloproteinase-9

2000 ◽  
Vol 275 (4) ◽  
pp. 2661-2668 ◽  
Author(s):  
Matthew W. Olson ◽  
M. Margarida Bernardo ◽  
Martin Pietila ◽  
David C. Gervasi ◽  
Marta Toth ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Matrix Metalloproteinase 9 ◽  
Active Matrix ◽  
Metalloproteinase 9

Construction, Expression, and Characterization of a Baculovirally Expressed Catalytic Domain of Human Matrix Metalloproteinase-9

2001 ◽  
Vol 23 (3) ◽  
pp. 447-452 ◽  
Author(s):  
Sepideh Sadatmansoori ◽  
John MacDougall ◽  
Shahram Khademi ◽  
Laurence S. Cooke ◽  
Linda Guarino ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Catalytic Domain ◽  
Matrix Metalloproteinase 9 ◽  
Metalloproteinase 9

scholarly journals Erratum to: The enhanced expression of the matrix metalloproteinase 9 in nasal NK/T-cell lymphoma

BMC Cancer ◽  
2008 ◽  
Vol 8 (1) ◽  
Author(s):  
Koh-ichi Sakata ◽  
Masanori Someya ◽  
Mutsuko Omatsu ◽  
Hiroko Asanuma ◽  
Tadashi Hasegawa ◽  
...  
Keyword(s):  
T Cell ◽  
Matrix Metalloproteinase ◽  
Cell Lymphoma ◽  
Matrix Metalloproteinase 9 ◽  
T Cell Lymphoma ◽  
The Matrix ◽  
Enhanced Expression ◽  
Nk T Cell ◽  
Metalloproteinase 9

Localization and Characterization of Matrix Metalloproteinase-9 in Experimental Rat Adjuvant Arthritis

1994 ◽  
Vol 732 (1 Inhibition of) ◽  
pp. 484-485 ◽  
Author(s):  
MONICA STEIN-PICARELLA ◽  
DIANE AHRENS ◽  
CAROL MASE ◽  
HARRY GOLDEN ◽  
MICHAEL J. NIEDBALA
Keyword(s):  
Matrix Metalloproteinase ◽  
Adjuvant Arthritis ◽  
Matrix Metalloproteinase 9 ◽  
Rat Adjuvant Arthritis ◽  
Metalloproteinase 9

scholarly journals Urinary Matrix Metalloproteinase-9 and Nephrin in Idiopathic Membranous Nephropathy: A Cross-Sectional Study

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Akankwasa Gilbert ◽  
An Changjuan ◽  
Cheng Guixue ◽  
Liu Jianhua ◽  
Qin Xiaosong
Keyword(s):  
Matrix Metalloproteinase ◽  
Membranous Nephropathy ◽  
Healthy Subjects ◽  
Kidney Injury ◽  
Matrix Metalloproteinase 9 ◽  
Idiopathic Membranous Nephropathy ◽  
Enzyme Linked Immunosorbent Assay ◽  
Cross Sectional ◽  
Glomerular Diseases ◽  
Metalloproteinase 9

Aim. Idiopathic membranous nephropathy (IMN) has a varied clinical course that requires accurate prediction as a prerequisite for treatment administration. Currently, its prognosis relies on proteinuria, a clinical parameter whose onset lags behind kidney injury. Increased urinary excretion of matrix metalloproteinase-9 (MMP-9) and nephrin has been reported in a number of IMN-like glomerular diseases in which they reflected disease severity. However, little or nothing is known of the importance of these biomarkers in IMN, a major cause of adult nephrotic syndrome. To highlight their potential, we measured both biomarkers and assessed their relationships with key parameters of renal function in IMN. Methods. We quantified urinary MMP-9 and nephrin in 107 biopsy-proven IMN patients and 70 healthy subjects by enzyme-linked immunosorbent assay (ELISA). We then compared biomarker levels between patients and healthy subjects and among patients with different clinical features. We also determined the relationship of each biomarker with proteinuria and the estimated glomerular filtration rate (eGFR). Results. Urinary MMP-9 and nephrin were significantly higher in IMN compared to healthy controls. Unlike nephrin, MMP-9 correlated significantly with proteinuria and was significantly higher among patients with nephrotic range proteinuria. Both biomarkers were correlated with eGFR, but only MMP-9 was significantly higher in patients with eGFR less than 90 ml/min/1.73 m2. Conclusion. Our findings suggest that urinary MMP-9 holds a greater potential than urinary nephrin in monitoring the severity of IMN.

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