scholarly journals Hypertonicity, but not hypothermia, elicits substance P release from rat C-fiber neurons in primary culture.

1995 ◽  
Vol 95 (5) ◽  
pp. 2359-2366 ◽  
Author(s):  
A Garland ◽  
J E Jordan ◽  
J Necheles ◽  
L E Alger ◽  
M M Scully ◽  
...  
Keyword(s):  
Substance P ◽  
Primary Culture ◽  
P Release ◽  
C Fiber ◽  
Substance P Release

Calcium and capsaicin- induced substance P release from peripheral terminals of primary sensory neurons

1988 ◽  
Vol 22 (1-2) ◽  
pp. 117 ◽  
Author(s):  
C.A. Maggi ◽  
P. Santicioli ◽  
P. Geppetti ◽  
R. Patacchini ◽  
E. Del Bianco ◽  
...  
Keyword(s):  
Substance P ◽  
Sensory Neurons ◽  
Primary Sensory Neurons ◽  
P Release ◽  
Substance P Release

scholarly journals Sufentanil, Morphine, Met-enkephalin, and k-Agonist (U-50,488H) Inhibit Substance P Release from Primary Sensory Neurons

1989 ◽  
Vol 70 (4) ◽  
pp. 672-677 ◽  
Author(s):  
H. Ming Chang ◽  
Charles B. Berde ◽  
George G. Holz ◽  
Grieg F. Steward ◽  
Richard M. Kream
Keyword(s):  
Substance P ◽  
Sensory Neurons ◽  
Primary Sensory Neurons ◽  
P Release ◽  
Inhibit Substance ◽  
Substance P Release

scholarly journals Effects of General Anesthetics on Substance P Release and c-Fos Expression in the Spinal Dorsal Horn

2013 ◽  
Vol 119 (2) ◽  
pp. 433-442 ◽  
Author(s):  
Toshifumi Takasusuki ◽  
Shigeki Yamaguchi ◽  
Shinsuke Hamaguchi ◽  
Tony L. Yaksh
Keyword(s):  
Nitrous Oxide ◽  
Substance P ◽  
Dorsal Horn ◽  
Receptor Internalization ◽  
General Anesthetics ◽  
Neurokinin 1 Receptor ◽  
P Release ◽  
Fos Expression ◽  
Neurokinin 1 ◽  
Substance P Release

Abstract Background: The authors examined in vivo the effects of general anesthetics on evoked substance P release (primary afferent excitability) and c-Fos expression (neuronal activation) in superficial dorsal horn. Methods: Rats received saline, propofol (100 mg/kg), pentobarbital (50 mg/kg), isoflurane (2 minimum alveolar concentration), nitrous oxide (66%), or fentanyl (30 μg/kg). During anesthesia, rats received intraplantar 5% formalin (50 μl) to left hind paw. Ten minutes later, rats underwent transcardial perfusion with 4% paraformaldehyde. Substance P release from small primary afferents was assessed by incidence of neurokinin 1 receptor internalization in the superficial dorsal horn. In separate studies, rats were sacrificed after 2 h and c-Fos expression measured. Results: Intraplantar formalin-induced robust neurokinin 1 receptor internalization in ipsilateral dorsal horn (ipsilateral: 54 ± 6% [mean ± SEM], contralateral: 12 ± 2%; P < 0.05; n = 4). Fentanyl, but not propofol, pentobarbital, isoflurane, nor nitrous oxide alone inhibited neurokinin 1 receptor internalization. However, 2 minimum alveolar concentration isoflurane + nitrous oxide reduced neurokinin 1 receptor internalization (27 ± 3%; P < 0.05; n = 5). All agents reduced c-Fos expression (control: 34 ± 4, fentanyl: 8 ± 2, isoflurane: 12 ± 3, nitrous oxide: 11 ± 2, isoflurane + nitrous oxide: 12 ± 1, pentobarbital: 11 ± 2, propofol: 13 ± 3; P < 0.05; n = 3). Conclusion: General anesthetics at anesthetic concentrations block spinal neuron activation through a mechanism that is independent of an effect on small primary afferent peptide release. The effect of fentanyl alone and the synergistic effect of isoflurane and nitrous oxide on substance P release suggest a correlative rationale for the therapeutic use of these anesthetic protocols by blocking nociceptive afferent transmitter release and preventing the initiation of cascade, which is immediately postsynaptic to the primary afferent.

scholarly journals Sensory neurons accelerate reepithelialization through Substance P release in an innervated tissue‐engineered model of skin wound healing.

2013 ◽  
Vol 27 (S1) ◽  
Author(s):  
Mathieu Blais ◽  
Lorène Mottier ◽  
Sébastien Cadau ◽  
Rémi Parenteau‐ Bareil ◽  
François Berthod
Keyword(s):  
Wound Healing ◽  
Substance P ◽  
Sensory Neurons ◽  
Skin Wound ◽  
Skin Wound Healing ◽  
P Release ◽  
Substance P Release

Spinal substance P release in vivo during the induction of long-term potentiation in dorsal horn neurons

Pain ◽  
2002 ◽  
Vol 96 (1) ◽  
pp. 49-55 ◽  
Author(s):  
Abdullahi Warsame Afrah ◽  
Atle Fiskå ◽  
Johannes Gjerstad ◽  
Henrik Gustafsson ◽  
Arne Tjølsen ◽  
...  
Keyword(s):  
Substance P ◽  
Dorsal Horn ◽  
Long Term Potentiation ◽  
Dorsal Horn Neurons ◽  
P Release ◽  
Term Potentiation ◽  
Substance P Release

Regulation of substance P release mediated via prejunctional histamine H3 receptors

1995 ◽  
Vol 273 (1-2) ◽  
pp. 83-88 ◽  
Author(s):  
Tsuyako Ohkubo ◽  
Manabu Shibata ◽  
Masayuki Inoue ◽  
Hidehiro Kaya ◽  
Hiroshi Takahashi
Keyword(s):  
Substance P ◽  
Histamine H3 Receptors ◽  
P Release ◽  
H3 Receptors ◽  
Substance P Release ◽  
Histamine H3

scholarly journals Noradrenaline regulates substance P release from rat dorsal root ganglion neurons in vitro

2011 ◽  
Vol 27 (5) ◽  
pp. 300-306 ◽  
Author(s):  
Yan-Jie Wang ◽  
Xing-Fu Li ◽  
Feng Ding ◽  
Qiang Shu ◽  
Li-Jun Song ◽  
...  
Keyword(s):  
Substance P ◽  
Dorsal Root Ganglion ◽  
Dorsal Root ◽  
Dorsal Root Ganglion Neurons ◽  
P Release ◽  
Ganglion Neurons ◽  
Substance P Release
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