scholarly journals Intercellular adhesion molecule-1 is upregulated on peripheral blood T lymphocyte subsets in dual asthmatic responders.

1994 ◽  
Vol 94 (5) ◽  
pp. 1840-1845 ◽  
Author(s):  
V De Rose ◽  
G Rolla ◽  
C Bucca ◽  
P Ghio ◽  
M Bertoletti ◽  
...  
Cardiology ◽  
2018 ◽  
Vol 139 (2) ◽  
pp. 110-118 ◽  
Author(s):  
Huiliang Wu ◽  
Jing Zhang

Objectives: The aim of this study was to evaluate the association of miR-126 with risk and severity of coronary artery disease (CAD) as well as its correlation with inflammatory cytokines and endothelial related proteins. Methods: In total, 215 patients suspected of CAD who underwent coronary angiography were enrolled in this case control study and were divided into a CAD group (n = 119) and control group (n = 96). miR-126 relative expression was assessed by real-time polymerase chain reaction. Results: The relative expression of miR-126 decreased in CAD patients compared to controls (p < 0.001), and the receiver operating characteristic curve showed a good diagnostic value of miR-126 for CAD risk with an area under the curve of 0.801 (95% CI 0.740-0.861). Additionally, miR-126 was negatively correlated with high-sensitivity C-reactive protein levels (p < 0.001) and reversely associated with TNF-α (p = 0.008) and IL-6 (p < 0.001) levels, while it was positively correlated with the IL-10 level (p < 0.001). In addition, miR-126 was negatively associated with intercellular adhesion molecule-1 (ICAM-1) levels (p = 0.001), and no association of miR-126 with vascular endothelial growth factor was detected (p = 0.142). Meanwhile, the miR-126 relative level was negatively associated with the Gensini score (p < 0.001). Conclusions: Peripheral blood mononuclear cell miR-126 predicts risk and severity and correlates with inflammatory cytokines as well as ICAM-1 in patients with CAD.


2014 ◽  
Vol 59 (1) ◽  
pp. 102-107 ◽  
Author(s):  
Andrzej Dabrowski ◽  
Joanna Osada ◽  
Milena I. Dabrowska ◽  
Urszula Wereszczynska-Siemiatkowska ◽  
Andrzej Siemiatkowski

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