scholarly journals Postcapillary venule endothelial cells in kidney express a multispecific chemokine receptor that is structurally and functionally identical to the erythroid isoform, which is the Duffy blood group antigen.

1994 ◽  
Vol 94 (3) ◽  
pp. 985-991 ◽  
Author(s):  
T J Hadley ◽  
Z H Lu ◽  
K Wasniowska ◽  
A W Martin ◽  
S C Peiper ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Blood Group ◽  
Chemokine Receptor ◽  
Blood Group Antigen ◽  
Postcapillary Venule ◽  
Duffy Blood Group

scholarly journals Differential expression of ACKR1 in cancer of the vulva.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Disease Progression ◽  
Differential Expression ◽  
Blood Group ◽  
Chemokine Receptor ◽  
Microarray Data ◽  
Transcriptome Analysis ◽  
Vulvar Cancer ◽  
Vulvar Carcinoma ◽  
Duffy Blood Group ◽  
Tissue Of Origin

In these brief notes we document work using published microarray data (1, 2) to pioneer integrative transcriptome analysis comparing vulvar carcinoma to its tissue of origin, the vulva. We report the differential expression of atypical chemokine receptor 1 (Duffy blood group), encoded by ACKR1, in cancer of the vulva. ACKR1 may be of pertinence to understanding transformation and disease progression in vulvar cancer (3).

scholarly journals Role ofPlasmodium vivaxDuffy-binding protein 1 in invasion of Duffy-null Africans

2016 ◽  
Vol 113 (22) ◽  
pp. 6271-6276 ◽  
Author(s):  
Karthigayan Gunalan ◽  
Eugenia Lo ◽  
Jessica B. Hostetler ◽  
Delenasaw Yewhalaw ◽  
Jianbing Mu ◽  
...  
Keyword(s):  
Blood Group ◽  
Malaria Parasite ◽  
Binding Protein ◽  
Squirrel Monkeys ◽  
Blood Group Antigen ◽  
Affinity Binding ◽  
Duffy Binding Protein ◽  
Duffy Blood Group ◽  
Duffy Antigen ◽  
The World

The ability of the malaria parasitePlasmodium vivaxto invade erythrocytes is dependent on the expression of the Duffy blood group antigen on erythrocytes. Consequently, Africans who are null for the Duffy antigen are not susceptible toP. vivaxinfections. Recently,P. vivaxinfections in Duffy-null Africans have been documented, raising the possibility thatP. vivax, a virulent pathogen in other parts of the world, may expand malarial disease in Africa.P. vivaxbinds the Duffy blood group antigen through its Duffy-binding protein 1 (DBP1). To determine if mutations in DBP1 resulted in the ability ofP. vivaxto bind Duffy-null erythrocytes, we analyzedP. vivaxparasites obtained from two Duffy-null individuals living in Ethiopia where Duffy-null and -positive Africans live side-by-side. We determined that, although the DBP1s from these parasites contained unique sequences, they failed to bind Duffy-null erythrocytes, indicating that mutations in DBP1 did not account for the ability ofP. vivaxto infect Duffy-null Africans. However, an unusual DNA expansion of DBP1 (three and eight copies) in the two Duffy-nullP. vivaxinfections suggests that an expansion of DBP1 may have been selected to allow low-affinity binding to another receptor on Duffy-null erythrocytes. Indeed, we show that Salvador (Sal) IP. vivaxinfects Squirrel monkeys independently of DBP1 binding to Squirrel monkey erythrocytes. We conclude thatP. vivaxSal I and perhapsP. vivaxin Duffy-null patients may have adapted to use new ligand–receptor pairs for invasion.

scholarly journals Differential expression of Duffy blood group chemokine receptor in cancers of the breast.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Differential Expression ◽  
Blood Group ◽  
Chemokine Receptor ◽  
Survival Data ◽  
Normal Breast ◽  
Differentially Expressed ◽  
Significant Differential Expression ◽  
Primary Tumors ◽  
Duffy Blood Group

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding the Duffy blood group chemokine receptor, DARC, also known as the atypical chemokine receptor 1, ACKR1, when comparing primary tumors of the breast to the tissue of origin, the normal breast. DARC mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of DARC in primary tumors of the breast was correlated with overall survival in patients with luminal A subtype cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by molecular subtype. DARC may be of relevance to initiation, maintenance or progression of cancers of the female breast.

The Duffy Blood Group Antigen: An Update

1994 ◽  
Vol 8 (4) ◽  
pp. 281-288 ◽  
Author(s):  
Kazimiera Wasniowska ◽  
Terence J. Hadley
Keyword(s):  
Blood Group ◽  
Blood Group Antigen ◽  
Duffy Blood Group

scholarly journals Distribution of ABO, Rh, MNSs, Kell and Duffy blood-group antigens in population of Vojvodina

2003 ◽  
Vol 56 (3-4) ◽  
pp. 173-177
Author(s):  
Svetlana Vojvodic
Keyword(s):  
Blood Group ◽  
American Indians ◽  
Significance Test ◽  
Blood Groups ◽  
Blood Group Antigen ◽  
Blood Group Antigens ◽  
Test Results ◽  
Australian Aborigines ◽  
Duffy Blood Group ◽  
Genotype Frequencies

Introduction Analysis of erythrocyte blood group antigen polymorphisms and genetic variability in population of Vojvodina was performed by investigating gene and genotype frequencies which determine antigens of ABO, Rh, MNSs, Kell and Duffy blood-group systems. Material and methods We investigated 350 unrelated persons from Vojvodina in regard to appurtenance of ABO, Rh, MNSs, Kell and Duffy blood-group systems. We calculated gene, genotype, phenotype frequencies and proportion significance test. Results and discussion Results of investigation revealed that gene and genotype frequencies of investigated blood-group systems are similar to corresponding data for majority of European populations, while statistically significant differences were established in inhabitants of geographically distant regions. Values of proportion significance test revealed statistically significant differences of genotype frequencies for ABO and MNSs blood-group antigens in populations of: Australian Aborigines, Chinese population, Arabians, Blacks, Eskimos, American Indians (Navaho and Pueblo) and population of Papua New Guinea. Statistically significant differences of genotype frequencies were established in inhabitants of narrow geographical areas of Europe such as: Finland, Germany, Sweden, Albania, England and Netherlands. Conclusion Our results point to the fact that erythrocyte blood-groups have different frequencies in some parts of the world, and that there are great differences in frequencies of some blood-groups among inhabitants of various continents and races. Genetical peculiarity of the population of Vojvodina points to the fact that differences in blood-group frequencies are also present among inhabitants of narrow geographical areas.

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