scholarly journals Interleukin-1 receptor antagonist decreases bone loss and bone resorption in ovariectomized rats.

1994 ◽  
Vol 93 (5) ◽  
pp. 1959-1967 ◽  
Author(s):  
R B Kimble ◽  
J L Vannice ◽  
D C Bloedow ◽  
R C Thompson ◽  
W Hopfer ◽  
...  
Keyword(s):  
Bone Resorption ◽  
Bone Loss ◽  
Receptor Antagonist ◽  
Interleukin 1 ◽  
Ovariectomized Rats ◽  
Interleukin 1 Receptor Antagonist

scholarly journals Inflammatory Bone Loss in Experimental Periodontitis Induced by Aggregatibacter actinomycetemcomitans in Interleukin-1 Receptor Antagonist Knockout Mice

2014 ◽  
Vol 82 (5) ◽  
pp. 1904-1913 ◽  
Author(s):  
A. Izawa ◽  
Y. Ishihara ◽  
H. Mizutani ◽  
S. Kobayashi ◽  
H. Goto ◽  
...  
Keyword(s):  
Bone Loss ◽  
Periodontal Disease ◽  
Receptor Antagonist ◽  
Mrna Expression ◽  
Interleukin 1 ◽  
Aggregatibacter Actinomycetemcomitans ◽  
Mrna Levels ◽  
Content Type ◽  
Interleukin 1 Receptor Antagonist ◽  
Experimental Periodontitis

ABSTRACTThe interleukin-1 receptor antagonist (IL-1Ra) binds to IL-1 receptors and inhibits IL-1 activity. However, it is not clear whether IL-1Ra plays a protective role in periodontal disease. This study was undertaken to compare experimental periodontitis induced byAggregatibacter actinomycetemcomitansin IL-1Ra knockout (KO) mice and wild-type (WT) mice. Computed tomography (CT) analysis and hematoxylin-and-eosin (H&E) and tartrate-resistant acid phosphatase (TRAP) staining were performed. In addition, osteoblasts were isolated; the mRNA expression of relevant genes was assessed by real-time quantitative PCR (qPCR); and calcification was detected by Alizarin Red staining. Infected IL-1Ra KO mice exhibited elevated (P, <0.05) levels of antibody againstA. actinomycetemcomitans, bone loss in furcation areas, and alveolar fenestrations. Moreover, protein for tumor necrosis factor alpha (TNF-α) and IL-6, mRNA for macrophage colony-stimulating factor (M-CSF), and receptor activator of NF-κB ligand (RANKL) in IL-1Ra KO mouse osteoblasts stimulated withA. actinomycetemcomitanswere increased (P, <0.05) compared to in WT mice. Alkaline phosphatase (ALP), bone sialoprotein (BSP), osteocalcin (OCN)/bone gla protein (BGP), and runt-related gene 2 (Runx2) mRNA levels were decreased (P, <0.05). IL-1α mRNA expression was increased, and calcification was not observed, in IL-1 Ra KO mouse osteoblasts. In brief, IL-1Ra deficiency promoted the expression of inflammatory cytokines beyond IL-1 and altered the expression of genes involved in bone resorption inA. actinomycetemcomitans-infected osteoblasts. Alterations consistent with rapid bone loss in infected IL-Ra KO mice were also observed for genes expressed in bone formation and calcification. In short, these data suggest that IL-1Ra may serve as a potential therapeutic drug for periodontal disease.

O1. Interleukin 1 receptor antagonist and postmenopausal bone loss

Bone ◽  
1994 ◽  
Vol 15 (2) ◽  
pp. 228-229
Author(s):  
RA Hannon ◽  
A Blumsohn ◽  
H Galatti ◽  
H Fenner ◽  
RGG Russell ◽  
...  
Keyword(s):  
Bone Loss ◽  
Receptor Antagonist ◽  
Interleukin 1 ◽  
Postmenopausal Bone Loss ◽  
Interleukin 1 Receptor Antagonist
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