scholarly journals Influence of the high-affinity growth hormone (GH)-binding protein on plasma profiles of free and bound GH and on the apparent half-life of GH. Modeling analysis and clinical applications.

1993 ◽  
Vol 91 (2) ◽  
pp. 629-641 ◽  
Author(s):  
J D Veldhuis ◽  
M L Johnson ◽  
L M Faunt ◽  
M Mercado ◽  
G Baumann
Keyword(s):  
Growth Hormone ◽  
Half Life ◽  
Binding Protein ◽  
Clinical Applications ◽  
High Affinity ◽  
Modeling Analysis

Response of High-Affinity Growth Hormone Binding Protein to Acute Heavy Resistance Exercise

2004 ◽  
Vol 36 (Supplement) ◽  
pp. S239
Author(s):  
Duncan N. French ◽  
Martyn R. Rubin ◽  
William J. Kraemer ◽  
Carl M. Maresh ◽  
Jeff S. Volek ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Resistance Exercise ◽  
Binding Protein ◽  
Hormone Binding ◽  
High Affinity ◽  
Growth Hormone Binding Protein ◽  
Hormone Binding Protein ◽  
Heavy Resistance Exercise

High affinity growth hormone binding protein in plasma of patients with acromegaly and the effect of octreotide treatment

1992 ◽  
Vol 37 (4) ◽  
pp. 373-378 ◽  
Author(s):  
C. A. M. Roelen ◽  
G. H. Donker ◽  
J. H. H. Thijssen ◽  
H. P. F. Koppeschaar ◽  
M. A. Blankenstein
Keyword(s):  
Growth Hormone ◽  
Binding Protein ◽  
Hormone Binding ◽  
High Affinity ◽  
Growth Hormone Binding Protein ◽  
Octreotide Treatment ◽  
Hormone Binding Protein

High-Affinity Growth Hormone Binding Protein and Acute Heavy Resistance Exercise

2005 ◽  
Vol 37 (3) ◽  
pp. 395-403 ◽  
Author(s):  
MARTYN R. RUBIN ◽  
WILLIAM J. KRAEMER ◽  
CARL M. MARESH ◽  
JEFF S. VOLEK ◽  
NICHOLAS A. RATAMESS ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Resistance Exercise ◽  
Binding Protein ◽  
Hormone Binding ◽  
High Affinity ◽  
Growth Hormone Binding Protein ◽  
Hormone Binding Protein ◽  
Heavy Resistance Exercise

scholarly journals Visceral Adipose Tissue Is Associated with Circulating High Affinity Growth Hormone-Binding Protein

1997 ◽  
Vol 82 (3) ◽  
pp. 760-764 ◽  
Author(s):  
Corné A. M. Roelen ◽  
Hans P. F. Koppeschaar ◽  
Wouter R. de Vries ◽  
Yvonne E. M. Snel ◽  
Manorath E. Doerga ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Adipose Tissue ◽  
Visceral Adipose Tissue ◽  
Binding Protein ◽  
Hormone Binding ◽  
High Affinity ◽  
Growth Hormone Binding Protein ◽  
Hormone Binding Protein ◽  
Visceral Adipose

scholarly journals Response of High-Affinity Growth Hormone Binding Protein to Acute Heavy Resistance Exercise

2004 ◽  
Vol 36 (Supplement) ◽  
pp. S239
Author(s):  
Duncan N. French ◽  
Martyn R. Rubin ◽  
William J. Kraemer ◽  
Carl M. Maresh ◽  
Jeff S. Volek ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Resistance Exercise ◽  
Binding Protein ◽  
Hormone Binding ◽  
High Affinity ◽  
Growth Hormone Binding Protein ◽  
Hormone Binding Protein ◽  
Heavy Resistance Exercise

High-affinity growth hormone binding protein, insulin-like growth factor I and insulin-like growth factor binding protein 3 in adults with growth hormone deficiency

1996 ◽  
Vol 135 (1) ◽  
pp. 82-86 ◽  
Author(s):  
Corné A Roelen ◽  
Hans P Koppeschaar ◽  
Wouter R de Vries ◽  
Pierre M Zelissen ◽  
Yvonne E Snel ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Factor ◽  
Gh Deficiency ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
High Affinity ◽  
Growth Hormone Binding Protein ◽  
Igf I ◽  
Hormone Binding Protein ◽  
Igfbp 3

Roelen CA, Koppeschaar HP, de Vries WR, Zelissen PM, Snel YE, Doerga ME, Thijssen JH, Blankenstein RA. High-affinity growth hormone binding protein, insulin-like growth factor I and insulin-like growth factor binding protein 3 in adults with growth hormone deficiency. Eur J Endocrinol 1996;135:82–6. ISSN 0804–4643 The high-affinity growth hormone binding protein (GHBP) circulates in human blood and represents the extracellular domain of the growth hormone (GH) receptor. The effects of GH deficiency on GHBP in adults are not clear. The aim of this study was to evaluate serum GHBP levels in adults with GH deficiency and to assess whether GHBP measurement may contribute to the diagnosis of adult GH deficiency, based on a two-step model. We measured insulin-like growth factor I (IGF-I), IGF binding protein 3 (IGFBP-3) and GHBP levels in serum samples of 36 patients with adult-onset GH deficiency. The GHBP levels were measured by FPLC size-exclusion chromatography; IGF-I and IGFBP-3 levels were measured by RIA. Serum GHBP levels were elevated above the upper limit of the 95% confidence interval in 26 patients, whereas IGF-I and IGFBP-3 levels were low in 10 patients and in 16 patients, respectively. The combination of low serum IGF-I and low IGFBP-3 levels was found in 10 patients. In nine patients, serum IGF-I levels were low, with elevated GHBP levels. Low serum IGF-I, low IGFBP-3 and elevated GHBP levels were found in five patients. Only four out of 36 patients had serum IGF-I, IGFBP-3 and GHBP levels that were within the 95% confidence interval of the control values. We conclude that adults with acquired GH deficiency have elevated GHBP levels in comparison to healthy subjects. We suggest that measurement of GHBP levels might contribute to the diagnosis of adult GH deficiency, though further research is required to study the additional value of GHBP measurements. HPF Koppeschaar, Department of Endocrinology, University Hospital Utrecht, HPL00.407, PO Box 85500, 3508 GA Utrecht, The Netherlands

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