scholarly journals Specificity of T cells invading the skin during acute graft-vs.-host disease after semiallogeneic bone marrow transplantation.

1993 ◽  
Vol 91 (1) ◽  
pp. 12-20 ◽  
Author(s):  
J Gaschet ◽  
B Mahé ◽  
N Milpied ◽  
M C Devilder ◽  
B Dréno ◽  
...  
Keyword(s):  
Bone Marrow ◽  
T Cells ◽  
Bone Marrow Transplantation ◽  
Marrow Transplantation ◽  
Host Disease ◽  
Graft Vs Host Disease ◽  
Acute Graft

Serum elastase and antithrombin-3 in patients with acute graft-vs.-host disease after bone marrow transplantation

2005 ◽  
Vol 19 (4) ◽  
pp. 466-469 ◽  
Author(s):  
Akinari Toda ◽  
Hiroyuki Takatsuka ◽  
Tosiyuki Nakajima ◽  
Kaori Nomura ◽  
Takeshi Wakae ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
Marrow Transplantation ◽  
Host Disease ◽  
Graft Vs Host Disease ◽  
Acute Graft

scholarly journals Accumulation of CD4+T cells in the colon of CsA-treated mice following myeloablative conditioning and bone marrow transplantation

2011 ◽  
Vol 300 (5) ◽  
pp. G843-G852 ◽  
Author(s):  
Jacqueline Perez ◽  
J. Anthony Brandon ◽  
Donald A. Cohen ◽  
C. Darrell Jennings ◽  
Alan M. Kaplan ◽  
...  
Keyword(s):  
Bone Marrow ◽  
T Cells ◽  
Cell Adhesion ◽  
Bone Marrow Transplantation ◽  
Marrow Transplantation ◽  
Time Course ◽  
Mrna Levels ◽  
Host Disease ◽  
T Effector Cells ◽  
Graft Vs Host Disease

Syngeneic graft vs. host disease (SGVHD) was first described as a graft vs. host disease-like syndrome that developed in rats following syngeneic bone marrow transplantation (BMT) and cyclosporin A (CsA) treatment. SGVHD can be induced by reconstitution of lethally irradiated mice with syngeneic bone marrow cells followed by 21 days of treatment with the immunosuppressive agent CsA. Clinical symptoms of the disease appear 2–3 wk following cessation of CsA therapy, and disease-associated inflammation occurs primarily in the colon and liver. CD4+T cells have been shown to play an important role in the inflammatory response observed in the gut of SGVHD mice. Time-course studies revealed a significant increase in migration of CD4+T cells into the colon during CsA therapy, as well as significantly elevated mRNA levels of TNF-α, proinflammatory chemokines, and cell adhesion molecules in colonic tissue of CsA-treated animals compared with BMT controls, as early as day 14 post-BMT. Homing studies revealed a greater migration of labeled CD4+T cells into the gut of CsA-treated mice at day 21 post-BMT than control animals via CsA-induced upregulation of mucosal addressin cell adhesion molecule. This study demonstrates that, during the 21 days of immunosuppressive therapy, functional mechanisms are in place that result in increased homing of CD4+T effector cells to colons of CsA-treated mice.

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