scholarly journals Phosphatidic acid as a second messenger in human polymorphonuclear leukocytes. Effects on activation of NADPH oxidase.

1991 ◽  
Vol 88 (2) ◽  
pp. 531-539 ◽  
Author(s):  
D E Agwu ◽  
L C McPhail ◽  
S Sozzani ◽  
D A Bass ◽  
C E McCall
Keyword(s):  
Nadph Oxidase ◽  
Phosphatidic Acid ◽  
Polymorphonuclear Leukocytes ◽  
Second Messenger ◽  
Human Polymorphonuclear Leukocytes

Characteristics of the cofactor requirements for the superoxide-generating NADPH oxidase of human polymorphonuclear leukocytes

Biochemistry ◽  
1981 ◽  
Vol 20 (6) ◽  
pp. 1468-1476 ◽  
Author(s):  
David R. Light ◽  
Christopher Walsh ◽  
Angela M. O'Callaghan ◽  
Edward J. Goetzl ◽  
Alfred I. Tauber
Keyword(s):  
Nadph Oxidase ◽  
Polymorphonuclear Leukocytes ◽  
Human Polymorphonuclear Leukocytes

Regulation of enzyme release from human polymorphonuclear leukocytes: further evidence for the independent regulation of granule subpopulations

1987 ◽  
Vol 65 (12) ◽  
pp. 1007-1015 ◽  
Author(s):  
Patricia Murphy ◽  
David A. Hart
Keyword(s):  
Polymorphonuclear Leukocytes ◽  
Second Messenger ◽  
Cytochalasin D ◽  
Enzyme Release ◽  
Specific Granules ◽  
Second Messenger Systems ◽  
Specific Granule ◽  
Human Polymorphonuclear Leukocytes

Addition of 5–20 mM LiCl to purified human polymorphonuclear leukocytes led to the release of lysozyme, the specific granule constituent, but not the release of elastase which is in azurophilic granules. In contrast, 2.5–10 μg cytochalasin D/mL induced the release of both lysozyme and elastase. Addition of lipopolysaccharide to leukocytes did not induce enzyme release but primed cells for enhanced release induced by cytochalasin D. Lipopolysaccharide also primed cells for enhanced release of lysozyme by either N-formylmethionylleucylphenylalanine (fMLP) or Li+ but did not prime cells for elastase release by these stimuli. In contrast, fMLP + cytochalasin D interacted synergistically, leading to enhanced elastase release but not lysozyme release from the cells. Additional experiments with combinations of secretogogues and lipopolysaccharide yielded results consistent with the hypothesis that specific granules and subpopulations of azurophilic granules are under separate regulation and, thus, may be influenced by separate elements of intracellular second messenger systems.

Influence of Hyperosmotic Environment Comparable to the Renal Medulla Upon Membrane NADPH Oxidase of Human Polymorphonuclear Leukocytes

1994 ◽  
Vol 152 (5 Part 1) ◽  
pp. 1622-1625 ◽  
Author(s):  
Koichi Takahashi ◽  
Tetsuro Matsumoto ◽  
Shuta Kubo ◽  
Masashi Haraoka ◽  
Masatoshi Tanaka ◽  
...  
Keyword(s):  
Nadph Oxidase ◽  
Polymorphonuclear Leukocytes ◽  
Renal Medulla ◽  
Human Polymorphonuclear Leukocytes ◽  
Hyperosmotic Environment
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