scholarly journals Hormone-mediated down-regulation of hepatic glutathione synthesis in the rat.

1991 ◽  
Vol 88 (1) ◽  
pp. 260-269 ◽  
Author(s):  
S C Lu ◽  
J Kuhlenkamp ◽  
C Garcia-Ruiz ◽  
N Kaplowitz
Keyword(s):  
Down Regulation ◽  
Glutathione Synthesis ◽  
Hepatic Glutathione

Toxic Doses of Acetaminophen Suppress Hepatic Glutathione Synthesis in Rats

Hepatology ◽  
2007 ◽  
Vol 2 (1) ◽  
pp. 8S-12S ◽  
Author(s):  
Bernhard H. Lauterburg ◽  
Jerry R. Mitchell
Keyword(s):  
Glutathione Synthesis ◽  
Hepatic Glutathione

Prednisolone stimulates hepatic glutathione synthesis in mice

1993 ◽  
Vol 18 (1) ◽  
pp. 62-67 ◽  
Author(s):  
Robert F. Speck ◽  
Christian Schranz ◽  
Bernhard H. Lauterburg
Keyword(s):  
Glutathione Synthesis ◽  
Hepatic Glutathione

scholarly journals A Western diet induced NAFLD in LDLR−− mice is associated with reduced hepatic glutathione synthesis

2016 ◽  
Vol 96 ◽  
pp. 13-21 ◽  
Author(s):  
Ling Li ◽  
Guo-Fang Zhang ◽  
Kwangwon Lee ◽  
Rocio Lopez ◽  
Stephen F. Previs ◽  
...  
Keyword(s):  
Western Diet ◽  
Glutathione Synthesis ◽  
Hepatic Glutathione

scholarly journals Biomarkers of Broccoli Consumption: Implications for Glutathione Metabolism and Liver Health

Nutrients ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2514
Author(s):  
Alicia Arredondo Eve ◽  
Xiaoji Liu ◽  
Yanling Wang ◽  
Michael J. Miller ◽  
Elizabeth H. Jeffery ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
De Novo ◽  
Plasma Metabolites ◽  
Glutathione Metabolism ◽  
Glutathione Synthesis ◽  
16S Sequencing ◽  
Hepatic Glutathione ◽  
Liver Health ◽  
Plasma Metabolite ◽  
Diet And Lifestyle

Diet and lifestyle choices contribute to obesity and liver disease. Broccoli, a brassica vegetable, may mitigate negative effects of both diet and lifestyle. Currently, there are no clinically relevant, established molecular biomarkers that reflect variability in human absorption of brassica bioactives, which may be the cause of variability/inconsistencies in health benefits in the human population. Here, we focused on the plasma metabolite profile and composition of the gut microbiome in rats, a relatively homogenous population in terms of gut microbiota, genetics, sex and diet, to determine if changes in the plasma metabolite profiles caused by dietary broccoli relate to molecular changes in liver. Our aim was to identify plasma indicators that reflect how liver health is impacted by dietary broccoli. Rats were fed a 10% broccoli diet for 14 days. We examined the plasma metabolite composition by metabolomics analysis using GC–MS and gut microbiota using 16S sequencing after 0, 1, 2, 4, 7, 14 days of broccoli feeding. We identified 25 plasma metabolites that changed with broccoli consumption, including metabolites associated with hepatic glutathione synthesis, and with de novo fatty acid synthesis. Glutamine, stearic acid, and S-methyl-L-cysteine (SMC) relative abundance changes correlated with changes in gut bacteria previously implicated in metabolic disease and with validated increases in expression of hepatic NAD(P)H dehydrogenase [quinone] 1 (NQO1) and nuclear factor (erythroid-derived 2)-like 2 (Nrf2), associated with elevated hepatic glutathione synthesis. Circulating biomarkers following broccoli consumption reflect gut–liver axis health.

Cholestatic Liver Injury Down-Regulates Hepatic Glutathione Synthesis

1996 ◽  
Vol 63 (2) ◽  
pp. 447-451 ◽  
Author(s):  
Brent A. Neuschwander-Tetri ◽  
Cynthia Nicholson ◽  
Lisa D. Wells ◽  
Thomas F. Tracy, Jr.
Keyword(s):  
Liver Injury ◽  
Glutathione Synthesis ◽  
Hepatic Glutathione ◽  
Cholestatic Liver Injury
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