scholarly journals Characterization of in vivo expression of the human papillomavirus type 16 E4 protein in cervical biopsy tissues.

1991 ◽  
Vol 87 (6) ◽  
pp. 2132-2141 ◽  
Author(s):  
J M Palefsky ◽  
B Winkler ◽  
J P Rabanus ◽  
C Clark ◽  
S Chan ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Human Papillomavirus Type 16 ◽  
Cervical Biopsy ◽  
In Vivo Expression

Protection against human papillomavirus type 16-E7 oncogene-induced tumorigenesis by in vivo expression of dominant-negative c-jun

2002 ◽  
Vol 34 (2) ◽  
pp. 72-77 ◽  
Author(s):  
Matthew R. Young ◽  
Linda Farrell ◽  
Paul Lambert ◽  
Parirokh Awasthi ◽  
Nancy H. Colburn
Keyword(s):  
Human Papillomavirus ◽  
Dominant Negative ◽  
Human Papillomavirus Type 16 ◽  
In Vivo Expression ◽  
E7 Oncogene

scholarly journals Identification and characterization of enhancer agonist human cytotoxic T-cell epitopes of the human papillomavirus type 16 (HPV16) E6/E7

Vaccine ◽  
2017 ◽  
Vol 35 (19) ◽  
pp. 2605-2611 ◽  
Author(s):  
Kwong Y. Tsang ◽  
Massimo Fantini ◽  
Romaine I. Fernando ◽  
Claudia Palena ◽  
Justin M. David ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
T Cell ◽  
Cytotoxic T Cell ◽  
T Cell Epitopes ◽  
Hpv16 E6 ◽  
Human Papillomavirus Type 16 ◽  
Identification And Characterization

Restoration of telomeres in human papillomavirus-immortalized human anogenital epithelial cells

1994 ◽  
Vol 14 (2) ◽  
pp. 961-969
Author(s):  
A J Klingelhutz ◽  
S A Barber ◽  
P P Smith ◽  
K Dyer ◽  
J K McDougall
Keyword(s):  
Human Papillomavirus ◽  
Epithelial Cells ◽  
Telomere Length ◽  
Open Reading Frames ◽  
Population Doubling ◽  
Telomere Shortening ◽  
Human Papillomavirus Type 16 ◽  
Immortalized Cells ◽  
E6 And E7

Loss of telomeres has been hypothesized to be important in cellular senescence and may play a role in carcinogenesis. In this study, we have measured telomere length in association with the immortalization and transformation of human cervical and foreskin epithelial cells by the human papillomavirus type 16 or 18 E6 and E7 open reading frames. By using a telomeric TTAGGG repeat probe, it was shown that the telomeres of precrisis normal and E6-, E7-, and E6/E7-expressing cells gradually shortened with passaging (30 to 100 bp per population doubling). Cells that expressed both E6 and E7 went through a crisis period and gave rise to immortalized lines. In contrast to precrisis cells, E6/E7-immortalized cells generally showed an increase in telomere length as they were passaged in culture, with some later passage lines having telomeres that were similar to or longer than the earliest-passage precrisis cells examined. No consistent association could be made between telomere length and tumorigenicity of cells in nude mice. However, of the three cell lines that grew in vivo, two had long telomeres, thus arguing against the hypothesis that cancer cells favor shortened telomeres. Our results indicate that arrest of telomere shortening may be important in human papillomavirus-associated immortalization and that restoration of telomere length may be advantageous to cells with regard to their ability to proliferate.

Studies on in Vivo Induction of Cytotoxic T Lymphocyte Responses by Synthetic Peptides from E6 and E7 Oncoproteins of Human Papillomavirus Type 16

1995 ◽  
Vol 8 (3) ◽  
pp. 165-174 ◽  
Author(s):  
ASIS K. SARKAR ◽  
GUILLERMO TORTOLERO-LUNA ◽  
PRAMOD N. NEHETE ◽  
RALPH B. ARLINGHAUS ◽  
MICHELE FOLLEN MITCHELL ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
T Lymphocyte ◽  
Synthetic Peptides ◽  
Cytotoxic T Lymphocyte ◽  
Human Papillomavirus Type 16 ◽  
E6 And E7 Oncoproteins ◽  
E6 And E7 ◽  
Lymphocyte Responses ◽  
In Vivo Induction

scholarly journals Restoration of telomeres in human papillomavirus-immortalized human anogenital epithelial cells.

1994 ◽  
Vol 14 (2) ◽  
pp. 961-969 ◽  
Author(s):  
A J Klingelhutz ◽  
S A Barber ◽  
P P Smith ◽  
K Dyer ◽  
J K McDougall
Keyword(s):  
Human Papillomavirus ◽  
Epithelial Cells ◽  
Telomere Length ◽  
Open Reading Frames ◽  
Population Doubling ◽  
Telomere Shortening ◽  
Human Papillomavirus Type 16 ◽  
Immortalized Cells ◽  
E6 And E7

Loss of telomeres has been hypothesized to be important in cellular senescence and may play a role in carcinogenesis. In this study, we have measured telomere length in association with the immortalization and transformation of human cervical and foreskin epithelial cells by the human papillomavirus type 16 or 18 E6 and E7 open reading frames. By using a telomeric TTAGGG repeat probe, it was shown that the telomeres of precrisis normal and E6-, E7-, and E6/E7-expressing cells gradually shortened with passaging (30 to 100 bp per population doubling). Cells that expressed both E6 and E7 went through a crisis period and gave rise to immortalized lines. In contrast to precrisis cells, E6/E7-immortalized cells generally showed an increase in telomere length as they were passaged in culture, with some later passage lines having telomeres that were similar to or longer than the earliest-passage precrisis cells examined. No consistent association could be made between telomere length and tumorigenicity of cells in nude mice. However, of the three cell lines that grew in vivo, two had long telomeres, thus arguing against the hypothesis that cancer cells favor shortened telomeres. Our results indicate that arrest of telomere shortening may be important in human papillomavirus-associated immortalization and that restoration of telomere length may be advantageous to cells with regard to their ability to proliferate.

scholarly journals Characterization of two new monoclonal antibodies against human papillomavirus type 16 L1 protein

2014 ◽  
Vol 9 (1) ◽  
pp. 101 ◽  
Author(s):  
Yan Wang ◽  
Qinglong Shang ◽  
Weizhen Xu ◽  
Di Li ◽  
Hongxi Gu ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Human Papillomavirus ◽  
Human Papillomavirus Type 16 ◽  
L1 Protein
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