scholarly journals The complete nucleotide sequences of the heavy chain variable regions of six monospecific rheumatoid factors derived from Epstein-Barr virus-transformed B cells isolated from the synovial tissue of patients with rheumatoid arthritis. Further evidence that some autoantibodies are unmutated copies of germ line genes.

1990 ◽  
Vol 86 (4) ◽  
pp. 1320-1328 ◽  
Author(s):  
V Pascual ◽  
I Randen ◽  
K Thompson ◽  
M Sioud ◽  
O Forre ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
B Cells ◽  
Synovial Tissue ◽  
Heavy Chain ◽  
Epstein Barr Virus ◽  
Germ Line ◽  
Rheumatoid Factors ◽  
Variable Regions ◽  
Barr Virus ◽  
Epstein Barr

scholarly journals Lytic Epstein‐Barr virus infection in the synovial tissue of patients with rheumatoid arthritis

2000 ◽  
Vol 43 (6) ◽  
pp. 1218-1225 ◽  
Author(s):  
Tsuyoshi Takeda ◽  
Yuzo Mizugaki ◽  
Lina Matsubara ◽  
Shosuke Imai ◽  
Takao Koike ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Virus Infection ◽  
Synovial Tissue ◽  
Epstein Barr Virus ◽  
Epstein Barr Virus Infection ◽  
Barr Virus ◽  
Epstein Barr ◽  
Barr Virus Infection

scholarly journals Rheumatoid Factors Induce Signaling from B Cells, Leading to Epstein-Barr Virus and B-Cell Activation

2004 ◽  
Vol 78 (18) ◽  
pp. 9918-9923 ◽  
Author(s):  
Lixin Yang ◽  
Masayuki Hakoda ◽  
Kazuya Iwabuchi ◽  
Tsuyoshi Takeda ◽  
Takao Koike ◽  
...  
Keyword(s):  
B Cells ◽  
B Cell ◽  
Epstein Barr Virus ◽  
Cell Activation ◽  
Mononuclear Cells ◽  
Rheumatoid Factors ◽  
B Cell Activation ◽  
Barr Virus ◽  
Membrane Bound ◽  
Epstein Barr

ABSTRACT B-cell antigen receptor signaling is initiated upon binding of the antigen to membrane-bound immunoblobulin (Ig), and the anti-Ig antibody (Ab) mimics this signaling. In B cells latently infected with Epstein-Barr virus (EBV), the same signals induce virus activation. We examine here whether rheumatoid factors (RFs), autoantibodies directed against the Fc portion of IgG, induce EBV and B-cell activation. As a source of RFs, RF-producing lymphoblastoid cell line (LCL) clones were isolated from peripheral blood mononuclear cells (PBMC) and synovial cells from patients with rheumatoid arthritis (RA) by EBV transformation. Burkitt's lymphoma-derived Akata cells, which are highly responsive to EBV activation by anti-Ig Abs, were used for the assay of EBV activation. Akata cells expressed IgG3 as membrane-bound Ig. RFs from a synovium-derived LCL were directed to IgG3 and induced EBV activation in 16 to 18% of Akata cells, whereas RFs from another synovium-derived LCL were directed to IgG1 and did not induce EBV activation. Pretreatment of RFs with the purified Fc fragment of human IgG completely abolished EBV activation. Furthermore, B-cell activation was assessed by incorporation of [3H]thymidine. RFs from synovium-derived LCLs efficiently induced B-cell activation, and the addition of CD40 ligand had a synergistic effect. On the other hand, RFs from PBMC-derived LCLs were polyreactive, had a lower affinity to IgG, and did not induce EBV and B-cell activation. The present findings imply a possible role for RFs as EBV and B-cell activators.

scholarly journals Abnormally elevated frequency of Epstein-Barr virus-infected B cells in the blood of patients with rheumatoid arthritis.

1984 ◽  
Vol 73 (6) ◽  
pp. 1789-1795 ◽  
Author(s):  
G Tosato ◽  
A D Steinberg ◽  
R Yarchoan ◽  
C A Heilman ◽  
S E Pike ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
B Cells ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
Epstein Barr ◽  
Elevated Frequency

Lysis of autologous Epstein-Barr virus-infected B cells by cytotoxic T lymphocytes of rheumatoid arthritis patients

1982 ◽  
Vol 24 (1) ◽  
pp. 8-14 ◽  
Author(s):  
Constantine D. Tsoukas ◽  
Dennis A. Carson ◽  
Sherman Fong ◽  
Susan F. Slovin ◽  
Robert I. Fox ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
B Cells ◽  
T Lymphocytes ◽  
Cytotoxic T Lymphocytes ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
Epstein Barr
Sign in / Sign up

Export Citation Format

Share Document