scholarly journals Disulfide-linked gamma delta T cell antigen receptors expressed on T cells derived from patients with primary immunodeficiency disorders.

1989 ◽  
Vol 84 (5) ◽  
pp. 1679-1682 ◽  
Author(s):  
H Seki ◽  
M Nanno ◽  
N K Day ◽  
R A Good ◽  
C D Platsoucas
Keyword(s):  
T Cells ◽  
T Cell ◽  
Primary Immunodeficiency ◽  
Antigen Receptors ◽  
Gamma Delta ◽  
Primary Immunodeficiency Disorders ◽  
Cell Antigen ◽  
T Cell Antigen Receptors ◽  
Gamma Delta T Cell

scholarly journals The delta TCS1 determinant is expressed on both disulfide- and non- disulfide-linked gamma delta T-cell antigen receptors [letter; comment]

Blood ◽  
1991 ◽  
Vol 77 (10) ◽  
pp. 2301-2303 ◽  
Author(s):  
CD Platsoucas ◽  
M Nanno ◽  
H Seki ◽  
G Mathioudakis ◽  
NK Day ◽  
...  
Keyword(s):  
T Cell ◽  
Antigen Receptors ◽  
Gamma Delta ◽  
Cell Antigen ◽  
Letter Comment ◽  
T Cell Antigen Receptors ◽  
Gamma Delta T Cell

Origin and selection of peripheral CD4−CD8− T cells bearing α/β T cell antigen receptors in autoimmunegld mice

1990 ◽  
Vol 20 (4) ◽  
pp. 723-730 ◽  
Author(s):  
Scott Wadsworth ◽  
Katsuyuki Yui ◽  
Richard M. Siegel ◽  
Drew E. Tenenholz ◽  
Joshua A. Hirsch ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Cd8 T Cells ◽  
Antigen Receptors ◽  
Cell Antigen ◽  
T Cell Antigen Receptors ◽  
Selection Of

scholarly journals Developmental arrest of NK1.1+ T cell antigen receptor (TCR)-alpha/beta+ T cells and expansion of NK1.1+ TCR-gamma/delta+ T cell development in CD3 zeta-deficient mice.

1995 ◽  
Vol 182 (3) ◽  
pp. 891-895 ◽  
Author(s):  
H Arase ◽  
S Ono ◽  
N Arase ◽  
S Y Park ◽  
K Wakizaka ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Antigen Receptor ◽  
Gamma Delta ◽  
T Cell Antigen Receptor ◽  
Cell Antigen Receptor ◽  
Cell Antigen ◽  
Alpha Beta ◽  
Gamma Delta T Cell ◽  
Deficient Mice

The relationship between the structure of the T cell antigen receptor (TCR)-CD3 complex and development of NK1.1+ T cells was investigated. The TCR complex of freshly isolated NK1.1+ TCR-alpha/beta+ thymocytes contained CD3 zeta homodimers and CD zeta-FcR gamma heterodimers, whereas that of the majority of NK1.1- T cells did not contain FcR gamma. The function of CD3 zeta and FcR gamma in the development of NK1.1+ T cells was determined by analyzing CD3 zeta- and FcR gamma-deficient mice. The NK1.1+ T cells from wild-type and CD3 zeta-deficient mice had equal levels of CD3 expression. However, the development of NK1.1+ TCR-alpha/beta+ T cells was almost completely disrupted in thymus and spleen in CD3 zeta-deficient mice, whereas no alteration was observed in FcR gamma-deficient mice. In contrast, the number of novel NK1.1+ TCR-gamma/delta+ thymocytes expressing a surface phenotype similar to NK1.1+ TCR-alpha/beta+ thymocytes increased approximately six times in CD3 zeta-deficient mice. These findings establish the distinct roles of the CD3 zeta chain in the development of the following different thymic T cell compartments: NK1.1- TCR+, NK1.1+ TCR-alpha/beta+, and NK1.1+ TCR-gamma/delta+ thymocytes, which cannot be replaced by CD3 eta or FcR gamma chains.

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