scholarly journals Basic fibroblast growth factor as a growth inhibitor for cultured human tumor cells.

1987 ◽  
Vol 80 (5) ◽  
pp. 1516-1520 ◽  
Author(s):  
L Schweigerer ◽  
G Neufeld ◽  
D Gospodarowicz
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Tumor Cells ◽  
Basic Fibroblast Growth Factor ◽  
Human Tumor ◽  
Growth Inhibitor ◽  
Fibroblast Growth ◽  
Human Tumor Cells

scholarly journals Expression of human basic fibroblast growth factor cDNA in baby hamster kidney-derived cells results in autonomous cell growth.

1988 ◽  
Vol 106 (4) ◽  
pp. 1385-1394 ◽  
Author(s):  
G Neufeld ◽  
R Mitchell ◽  
P Ponte ◽  
D Gospodarowicz
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Basic Fibroblast Growth Factor ◽  
Constitutive Expression ◽  
Human Tumor ◽  
Soft Agar ◽  
Biologically Active ◽  
Fibroblast Growth ◽  
Baby Hamster Kidney ◽  
High Concentration

Growth factor over-production by responsive cells might contribute to their autonomous proliferation as well as their acquisition of a transformed phenotype in culture. Basic fibroblast growth factor (bFGF) has been shown to induce transient changes in cell behavior that resemble those encountered in transformed cells. In addition, several types of human tumor cells have been shown to produce bFGF. To determine directly the role that bFGF might play in the induction of the transformed phenotype, we have introduced a human bFGF cDNA expression vector into baby hamster kidney-derived (BHK-21) fibroblasts. One of the BHK transfectants, termed clone 19, expresses the bFGF mRNA and produces biologically active bFGF that accumulates to a high concentration inside the cells. These properties correlate with the ability of the cells to grow in serum-free medium without the addition of exogenous bFGF. Clone 19 cells also proliferated in soft agar, indicating that constitutive expression of the bFGF gene results in a loss of anchorage-dependent growth.

Both normal and tumor cells produce basic fibroblast growth factor

1986 ◽  
Vol 129 (2) ◽  
pp. 273-276 ◽  
Author(s):  
David Moscatelli ◽  
Marco Presta ◽  
Jacquelyn Joseph-Silverstein ◽  
Daniel B. Rifkin
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Tumor Cells ◽  
Basic Fibroblast Growth Factor ◽  
Fibroblast Growth

Basic fibroblast growth factor-binding peptide as a novel targeting ligand of drug carrier to tumor cells

2006 ◽  
Vol 14 (8) ◽  
pp. 536-545 ◽  
Author(s):  
Takeshi Terada ◽  
Miki Mizobata ◽  
Shigeru Kawakami ◽  
Yoshiyuki Yabe ◽  
Fumiyoshi Yamashita ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Tumor Cells ◽  
Basic Fibroblast Growth Factor ◽  
Drug Carrier ◽  
Fibroblast Growth ◽  
Binding Peptide ◽  
Factor Binding
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