scholarly journals Spontaneous expression of the c-sis gene and release of a platelet-derived growth factorlike molecule by human alveolar macrophages.

1986 ◽  
Vol 78 (1) ◽  
pp. 61-66 ◽  
Author(s):  
J F Mornex ◽  
Y Martinet ◽  
K Yamauchi ◽  
P B Bitterman ◽  
G R Grotendorst ◽  
...  
Keyword(s):  
Alveolar Macrophages ◽  
Human Alveolar Macrophages ◽  
Spontaneous Expression

Hypoxia triggers an antimicrobial pathway in human alveolar macrophages

Pneumologie ◽  
2010 ◽  
Vol 64 (S 03) ◽  
Author(s):  
S Stenger ◽  
D Nickel ◽  
M Wagner ◽  
JH Ficker ◽  
C Schumann
Keyword(s):  
Alveolar Macrophages ◽  
Human Alveolar Macrophages

scholarly journals Bacillus anthracis Spores Stimulate Cytokine and Chemokine Innate Immune Responses in Human Alveolar Macrophages through Multiple Mitogen-Activated Protein Kinase Pathways

2006 ◽  
Vol 74 (8) ◽  
pp. 4430-4438 ◽  
Author(s):  
Kaushik Chakrabarty ◽  
Wenxin Wu ◽  
J. Leland Booth ◽  
Elizabeth S. Duggan ◽  
K. Mark Coggeshall ◽  
...  
Keyword(s):  
Immune System ◽  
Bacillus Anthracis ◽  
Alveolar Macrophages ◽  
Innate Immune System ◽  
Innate Immune ◽  
Mitogen Activated Protein Kinase ◽  
Tnf Α ◽  
Human Alveolar Macrophages ◽  
Mitogen Activated Protein ◽  
Multiple Signaling

ABSTRACT Contact with the human alveolar macrophage plays a key role in the innate immune response to Bacillus anthracis spores. Because there is a significant delay between the initial contact of the spore with the host and clinical evidence of disease, there appears to be temporary containment of the pathogen by the innate immune system. Therefore, the early macrophage response to Bacillus anthracis exposure is important in understanding the pathogenesis of this disease. In this paper, we studied the initial events after exposure to spores, beginning with the rapid internalization of spores by the macrophages. Spore exposure rapidly activated the mitogen-activated protein kinase signaling pathways extracellular signal-regulated kinase, c-Jun-NH2-terminal kinase, and p38. This was followed by the transcriptional activation of cytokine and primarily monocyte chemokine genes as determined by RNase protection assays. Transcriptional induction is reflected at the translational level, as interleukin-1α (IL-1α), IL-1β, IL-6, and tumor necrosis factor alpha (TNF-α) cytokine protein levels were markedly elevated as determined by enzyme-linked immunosorbent assay. Induction of IL-6 and TNF-α, and, to a lesser extent, IL-1α and IL-1β, was partially inhibited by the blockade of individual mitogen-activated protein kinases, while the complete inhibition of cytokine induction was achieved when multiple signaling pathway inhibitors were used. Taken together, these data clearly show activation of the innate immune system in human alveolar macrophages by Bacillus anthracis spores. The data also show that multiple signaling pathways are involved in this cytokine response. This report is the first comprehensive examination of this process in primary human alveolar macrophages.

scholarly journals Interleukin-12 Production by Human Alveolar Macrophages Is Controlled by the Autocrine Production of Interleukin-10

1999 ◽  
Vol 20 (2) ◽  
pp. 270-278 ◽  
Author(s):  
Patrick Isler ◽  
Béatrice Galve de Rochemonteix ◽  
Fadia Songeon ◽  
Nicole Boehringer ◽  
Laurent P. Nicod
Keyword(s):  
Alveolar Macrophages ◽  
Interleukin 10 ◽  
Interleukin 12 ◽  
Human Alveolar Macrophages

Androstenedione Metabolism in Human Alveolar Macrophages*

1983 ◽  
Vol 56 (5) ◽  
pp. 920-924 ◽  
Author(s):  
Leon Milewich ◽  
Valsala Kaimal ◽  
Galen B. Toews
Keyword(s):  
Alveolar Macrophages ◽  
Human Alveolar Macrophages

Expression of High-Affinity IgE Receptor (FcεRI) on Human Alveolar Macrophages from Atopic and Non-Atopic Patients

1996 ◽  
Vol 111 (1) ◽  
pp. 55-58 ◽  
Author(s):  
Kenichi Ochiai ◽  
Masaru Kagami ◽  
Keiko Umemiya ◽  
Ryutaro Matsumura ◽  
Tatsuo Kawashima ◽  
...  
Keyword(s):  
Alveolar Macrophages ◽  
Ige Receptor ◽  
High Affinity ◽  
Human Alveolar Macrophages ◽  
High Affinity Ige Receptor

scholarly journals Induction of TNF in Human Alveolar Macrophages As a Potential Evasion Mechanism of VirulentMycobacterium tuberculosis

2002 ◽  
Vol 168 (3) ◽  
pp. 1328-1337 ◽  
Author(s):  
Matthias Engele ◽  
Elmar Stöβel ◽  
Kirstin Castiglione ◽  
Nives Schwerdtner ◽  
Manfred Wagner ◽  
...  
Keyword(s):  
Alveolar Macrophages ◽  
Human Alveolar Macrophages

scholarly journals Chemotactic and phagocytic responses of human alveolar macrophages to activated complement components.

1984 ◽  
Vol 43 (2) ◽  
pp. 775-778 ◽  
Author(s):  
S W Richards ◽  
P K Peterson ◽  
H A Verbrugh ◽  
R D Nelson ◽  
D E Hammerschmidt ◽  
...  
Keyword(s):  
Alveolar Macrophages ◽  
Complement Components ◽  
Human Alveolar Macrophages
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