scholarly journals A monoclonal antibody against basal cells of human epidermis. Potential use in the diagnosis of cervical neoplasia.

1985 ◽  
Vol 76 (5) ◽  
pp. 1978-1983 ◽  
Author(s):  
V B Morhenn ◽  
A B Schreiber ◽  
O Soriero ◽  
W McMillan ◽  
A C Allison
Keyword(s):  
Monoclonal Antibody ◽  
Cervical Neoplasia ◽  
Human Epidermis ◽  
Basal Cells ◽  
Potential Use

Potential Use of Monoclonal Antibody–Drug Conjugates to Prevent Drug Resistance

1988 ◽  
pp. 371-383 ◽  
Author(s):  
CARL-WILHELM VOGEL ◽  
REINHARD BREDEHORST ◽  
MOUNANANDHAM PANNEERSELVAM ◽  
CAROLE J. SPANGLER
Keyword(s):  
Monoclonal Antibody ◽  
Drug Resistance ◽  
Antibody Drug Conjugates ◽  
Drug Conjugates ◽  
Potential Use ◽  
Antibody Drug

scholarly journals Monoclonal antibodies directed against the flagella ofCampylobacter jejuni: cross-reacting and serotypic specificity and potential use in diagnosis

1986 ◽  
Vol 96 (3) ◽  
pp. 377-384 ◽  
Author(s):  
D. G. Newell
Keyword(s):  
Monoclonal Antibody ◽  
Monoclonal Antibodies ◽  
Campylobacter Jejuni ◽  
Clinical Material ◽  
Faecal Material ◽  
Ofcampylobacter Jejuni ◽  
Elisa Technique ◽  
Flagellar Antigen ◽  
Potential Use

SUMMARYNine monoclonal antibodies directed against the flagella ofCampylobacter jejunistrain 81116 have been investigated for serotypic and cross-reacting activity using a panel of 17 Penner serotype strains ofC. jejuni.Four monoclonal antibodies were exclusively specific for serotype-6 strains, which was the serotype ofC. jejunistrain 81116. Two monoclonal antibodies cross-reacted with all the flagellated strains ofC jejunitested. One of these cross-reacting monoclonal antibodies, CF5, was found to react with all otherCampylobacterspecies exceptC. sputorum bulbulusbut it did not react with other bacterial entcropathogens. An antigencapture ELISA technique was established, using this monoclonal antibody, which could detect flagellar antigen in human faecal material. These anti-flagella monoclonal antibodies therefore may be valuable in the diagnosis and serotyping ofC. jejuniin clinical material.

A Potential Use of a Monoclonal Antibody to Placental Alkaline Phosphatase (PLAP) to Detect Lymph Node Metastases of Seminoma

1996 ◽  
Vol 155 (1) ◽  
pp. 337-341 ◽  
Author(s):  
Kiyoshi Koshida ◽  
Tadao Uchibayashi ◽  
Hajime Yamamoto ◽  
Kunihiko Yokoyama ◽  
Kazuyuki Hirano
Keyword(s):  
Monoclonal Antibody ◽  
Alkaline Phosphatase ◽  
Lymph Node ◽  
Lymph Node Metastases ◽  
Placental Alkaline Phosphatase ◽  
Node Metastases ◽  
Potential Use

High throughput chromatography strategies for potential use in the formal process characterization of a monoclonal antibody

2015 ◽  
Vol 113 (6) ◽  
pp. 1273-1283 ◽  
Author(s):  
Matthew G. Petroff ◽  
Haiying Bao ◽  
John P. Welsh ◽  
Miranda van Beuningen - de Vaan ◽  
Jennifer M. Pollard ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
High Throughput ◽  
Formal Process ◽  
Process Characterization ◽  
Potential Use

Expression of protein p27 in various forms of seborrheic keratosis

2016 ◽  
Vol 19 (5) ◽  
pp. 283-286
Author(s):  
Alexandra K. Aleksandrova ◽  
G. I Sukolin ◽  
V. A Smolynnikova
Keyword(s):  
Cell Cycle ◽  
Monoclonal Antibody ◽  
Kinase Inhibitor ◽  
Research Unit ◽  
Basal Cells ◽  
Seborrheic Keratosis ◽  
Histological Types ◽  
Characteristic Features ◽  
Definition Of ◽  
P27 Kip1

The significant role in the pathogenesis of seborrheic keratosis (SK) plays the violation of the cell cycle regulation. According to the research unit the cell proliferation in acanthotic and irritated histological types of SK is regulated by p27 (Kip1), cyclin-dependent kinase inhibitor. Considering the variety of histological types of SK, definition of p27 expression will reveal the characteristic features of the cell cycle disorders and proliferation for each type of tumor. Material and Methods. Of the 102 tumors from patients with SK, according to the results of histological examination, were selected 10 specimens of each histological types of SK: acanthotic, hyperkeratotic, adenoid, irritated, and clonal. We assessed all specimens for p27 (Kip1) expression using immunohistochemistry (monoclonal antibody p27 at a dilution of 1:20 (Novocastra Laboratories Ltd.). Three skin biopsy samples of healthy individuals were included. Results. Severe diffuse nuclear expression of p27 was present in all cases of adenoid, irritated, and 4 cases of clonal histological types of SK. In other tumor types positive reaction with monoclonal antibody to p27 was reduced as compared with healthy skin were recorded single positively stained nuclei of basal cells. Conclusions. Thus, we have found a violation of p27 protein expression in all types of seborrheic keratosis as with the excess (adenoid, irritated, clonal SK type) and in p27 protein deficiency (acanthotic, hyperkeratotic) normal course of cell cycle phases is broken. This leads to the disappearance of control over the cell proliferative activity and apoptosis, facilitating a slow, uncontrolled growth of SK cells.

scholarly journals Characterization of a Broadly Reactive Anti-CD40 Agonistic Monoclonal Antibody for Potential Use as an Adjuvant

PLoS ONE ◽  
2017 ◽  
Vol 12 (1) ◽  
pp. e0170504 ◽  
Author(s):  
Cameron Martin ◽  
Suryakant D. Waghela ◽  
Shehnaz Lokhandwala ◽  
Andy Ambrus ◽  
Jocelyn Bray ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Potential Use
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