scholarly journals Abnormal copper metabolism and deficient lysyl oxidase activity in a heritable connective tissue disorder.

1982 ◽  
Vol 69 (3) ◽  
pp. 730-733 ◽  
Author(s):  
H Kuivaniemi ◽  
L Peltonen ◽  
A Palotie ◽  
I Kaitila ◽  
K I Kivirikko
Keyword(s):  
Connective Tissue ◽  
Oxidase Activity ◽  
Lysyl Oxidase ◽  
Copper Metabolism ◽  
Connective Tissue Disorder

scholarly journals Copper metabolism in mottled mouse mutants. The effect of copper therapy on lysyl oxidase activity in brindled (Mobr) mice

1982 ◽  
Vol 202 (2) ◽  
pp. 369-371 ◽  
Author(s):  
P M Royce ◽  
J Camakaris ◽  
J R Mann ◽  
D M Danks
Keyword(s):  
Acid Solution ◽  
Subcutaneous Injection ◽  
Oxidase Activity ◽  
Lysyl Oxidase ◽  
Sebacic Acid ◽  
Copper Metabolism ◽  
Single Subcutaneous Injection ◽  
Mouse Mutants ◽  
Copper Therapy ◽  
Effect Of Copper

Lysyl oxidase activity in extracts of skin from 1-day-old Mobr/Y mice was found to be between 50 and 60% of that in corresponding extracts from littermate +/Y mice of the same age. It was increased to 84-150% of that in the latter by prior treatment of the Mobr/Y mice at 7 days of age with a single subcutaneous injection of 50 micrograms of copper, retained as Cu+ in an alkyl polyether/sebacic acid solution. This suggests that in this form the copper is able to by-pass the block in copper metabolism and is deliverable to copper-requiring processes.

scholarly journals Atypical presentation of rheumatoid arthritis: a case of massive bilateral pleural effusions in a patient with Caplan syndrome

2019 ◽  
Vol 12 (10) ◽  
pp. e231899
Author(s):  
Yinglun Wu ◽  
Philip C Dittmar
Keyword(s):  
Rheumatoid Arthritis ◽  
Atrial Fibrillation ◽  
Pleural Effusion ◽  
Connective Tissue ◽  
Minimal Change Disease ◽  
Connective Tissue Disorder ◽  
Minimal Change ◽  
Atypical Presentation ◽  
Pleural Effusions ◽  
Recent Treatment

Rheumatoid arthritis (RA) is a common connective tissue disorder affecting the synovial joints. In patients with RA, involvement of the lungs occurs in 30%–40% of cases while pleural effusions occur in only 3%–5%. However, the majority of RA-associated pleural effusions are small, unilateral and asymptomatic. We present a case of massive bilateral pleural effusions in a patient with established rheumatoid pneumoconiosis (Caplan syndrome). Interestingly, the pleural effusion occurred following recent treatment for minimal change disease and atrial fibrillation.

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