scholarly journals Physiologic evaluation of factors controlling glucose tolerance in man: measurement of insulin sensitivity and beta-cell glucose sensitivity from the response to intravenous glucose.

1981 ◽  
Vol 68 (6) ◽  
pp. 1456-1467 ◽  
Author(s):  
R N Bergman ◽  
L S Phillips ◽  
C Cobelli
Keyword(s):  
Insulin Sensitivity ◽  
Glucose Tolerance ◽  
Beta Cell ◽  
Intravenous Glucose ◽  
Beta Cell Glucose Sensitivity ◽  
Glucose Sensitivity ◽  
Cell Glucose

scholarly journals Impaired beta cell glucose sensitivity and whole-body insulin sensitivity as predictors of hyperglycaemia in non-diabetic subjects

Diabetologia ◽  
2005 ◽  
Vol 48 (12) ◽  
pp. 2470-2476 ◽  
Author(s):  
M. Walker ◽  
A. Mari ◽  
M. K. Jayapaul ◽  
S. M. A. Bennett ◽  
E. Ferrannini
Keyword(s):  
Insulin Sensitivity ◽  
Beta Cell ◽  
Whole Body ◽  
Beta Cell Glucose Sensitivity ◽  
Glucose Sensitivity ◽  
Cell Glucose

scholarly journals Impaired beta cell glucose sensitivity and whole-body insulin sensitivity as predictors of hyperglycaemia in non-diabetic subjects

Diabetologia ◽  
2006 ◽  
Vol 49 (6) ◽  
pp. 1456-1456 ◽  
Author(s):  
M. Walker ◽  
A. Mari ◽  
M. K. Jayapaul ◽  
S. M. A. Bennett ◽  
E. Ferrannini
Keyword(s):  
Insulin Sensitivity ◽  
Beta Cell ◽  
Whole Body ◽  
Beta Cell Glucose Sensitivity ◽  
Glucose Sensitivity ◽  
Cell Glucose

scholarly journals Genome-Wide Association Analysis of Pancreatic Beta-Cell Glucose Sensitivity

2020 ◽  
Vol 106 (1) ◽  
pp. 80-90
Author(s):  
Harshal A Deshmukh ◽  
Anne Lundager Madsen ◽  
Ana Viñuela ◽  
Christian Theil Have ◽  
Niels Grarup ◽  
...  
Keyword(s):  
Beta Cell ◽  
Meta Analysis ◽  
Pancreatic Beta Cell ◽  
P Value ◽  
Genetic Determinants ◽  
Genome Wide ◽  
Beta Cell Glucose Sensitivity ◽  
Glucose Sensitivity ◽  
Cell Glucose

Abstract Context Pancreatic beta-cell glucose sensitivity is the slope of the plasma glucose-insulin secretion relationship and is a key predictor of deteriorating glucose tolerance and development of type 2 diabetes. However, there are no large-scale studies looking at the genetic determinants of beta-cell glucose sensitivity. Objective To understand the genetic determinants of pancreatic beta-cell glucose sensitivity using genome-wide meta-analysis and candidate gene studies. Design We performed a genome-wide meta-analysis for beta-cell glucose sensitivity in subjects with type 2 diabetes and nondiabetic subjects from 6 independent cohorts (n = 5706). Beta-cell glucose sensitivity was calculated from mixed meal and oral glucose tolerance tests, and its associations between known glycemia-related single nucleotide polymorphisms (SNPs) and genome-wide association study (GWAS) SNPs were estimated using linear regression models. Results Beta-cell glucose sensitivity was moderately heritable (h2 ranged from 34% to 55%) using SNP and family-based analyses. GWAS meta-analysis identified multiple correlated SNPs in the CDKAL1 gene and GIPR-QPCTL gene loci that reached genome-wide significance, with SNP rs2238691 in GIPR-QPCTL (P value = 2.64 × 10−9) and rs9368219 in the CDKAL1 (P value = 3.15 × 10−9) showing the strongest association with beta-cell glucose sensitivity. These loci surpassed genome-wide significance when the GWAS meta-analysis was repeated after exclusion of the diabetic subjects. After correction for multiple testing, glycemia-associated SNPs in or near the HHEX and IGF2B2 loci were also associated with beta-cell glucose sensitivity. Conclusion We show that, variation at the GIPR-QPCTL and CDKAL1 loci are key determinants of pancreatic beta-cell glucose sensitivity.

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