scholarly journals Influence of surgically induced varicocele on testicular blood flow, temperature, and histology in adult rats and dogs.

1981 ◽  
Vol 68 (1) ◽  
pp. 39-45 ◽  
Author(s):  
D C Saypol ◽  
S S Howards ◽  
T T Turner ◽  
E D Miller
1983 ◽  
Vol 98 (1) ◽  
pp. 35-46 ◽  
Author(s):  
J. Wang ◽  
K. A. A. Galil ◽  
B. P. Setchell

Exposure of the testes of anaesthetized adult rats to 527 rads of γ-irradiation caused testis weight to fall slowly at first and then more rapidly from 21 days afterwards, reaching a minimum at 52 days, when spermatogenesis was severely disrupted. The weights of the accessory organs and the concentrations of testosterone in peripheral blood were slightly reduced; the concentrations in blood from the testicular veins were lower than control at shorter intervals after irradiation, but at later times tended to be similar or greater than control. Testicular blood flow per testis followed testis weight closely, and as a result the production of testosterone by the smaller testes (calculated as the product of plasma flow and the veno–arterial difference in testosterone concentration) was markedly reduced especially when the rats had been stimulated with human chorionic gonadotrophin (hCG). Serum FSH and LH rose appreciably as testis weight fell but there was a proportionately greater rise in FSH than LH, in comparison with surgically castrated animals. Increased amounts of extratubular, extracellular fluid were found in the aspermatogenic testes, but injection of hCG still caused increases in capillary permeability and the amount of fluid in the testis. These results indicate that during aspermatogenesis following irradiation (as with heat and efferent duct ligation) the capacity of the testes to secrete testosterone is severely limited by decreased testicular blood flow, not by the ability of the Leydig cells to release testosterone into their immediate environment.


1997 ◽  
Vol 68 ◽  
pp. S108-S109
Author(s):  
H.K Li ◽  
F Dubocq ◽  
F Bianco ◽  
V.K George ◽  
S.C Crawford ◽  
...  

1986 ◽  
Vol 109 (3) ◽  
pp. 419-425 ◽  
Author(s):  
A. Widmark ◽  
J. E. Damber ◽  
A. Bergh

ABSTRACT The relationship between testicular vascular permeability and testicular microcirculation as measured by laser Doppler flowmetry was studied in adult rats. In untreated control animals there was an oscillatory testicular blood-flow pattern with a frequency of 10·6 ± 0·8 pulses/min and the amount of testicular interstitial fluid (IF) collected was 61·5 ± 2·2 μl/g testis. Treatment of the rats with 25–200 i.u. human chorionic gonadotrophin (hCG) s.c. 8 h before the experiment resulted in a change in the testicular flow pattern from pulsatile to continuous and an increase in IF volume. Treatment with hCG (50 i.u., s.c.) changed the testicular blood-flow pattern from oscillatory to continuous 4, 8 and 16 h after treatment. The flow pattern returned to being pulsatile 32 h after treatment with hCG. The IF information was increased at those times when the blood-flow pattern was continuous. No effects on blood flow or IF formation were observed with 12·5 i.u. hCG s.c. The present study shows a dose- and time-dependent covariation between the increase in testicular IF volume and the disappearance of the pulsatile flow in testicular microcirculation. It appears that a continuous flow pattern favours the transport of fluid from blood vessels to the interstitium. J. Endocr. (1986) 109, 419–425


1983 ◽  
Vol 4 (4) ◽  
pp. 256-260 ◽  
Author(s):  
RICHARD M. HARRISON ◽  
RONALD W. LEWIS ◽  
JAMES A. ROBERTS

Urology ◽  
1999 ◽  
Vol 53 (6) ◽  
pp. 1258-1262 ◽  
Author(s):  
Haikun Li ◽  
Francisco Dubocq ◽  
Yang Jiang ◽  
Rabi Tiguert ◽  
Edward L Gheiler ◽  
...  

Choonpa Igaku ◽  
2014 ◽  
Vol 41 (6) ◽  
pp. 801-810
Author(s):  
Kimihiko MORIYA

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