scholarly journals Alterations in immunoregulatory T cell subsets in active systemic lupus erythematosus.

1980 ◽  
Vol 66 (5) ◽  
pp. 1171-1174 ◽  
Author(s):  
C Morimoto ◽  
E L Reinherz ◽  
S F Schlossman ◽  
P H Schur ◽  
J A Mills ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
T Cell ◽  
Lupus Erythematosus ◽  
Active Systemic Lupus Erythematosus ◽  
T Cell Subsets ◽  
Systemic Lupus

scholarly journals Phenotypic and functional similarities between 5-azacytidine-treated t cells and a t cell subset in patients with active systemic lupus erythematosus

1992 ◽  
Vol 35 (6) ◽  
pp. 647-662 ◽  
Author(s):  
Bruce C. Richardson ◽  
John R. Strahler ◽  
T. Scott Pivirotto ◽  
Jawaid Quddus ◽  
Garry E. Bayliss ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
T Cells ◽  
T Cell ◽  
Lupus Erythematosus ◽  
Cell Subset ◽  
Active Systemic Lupus Erythematosus ◽  
Systemic Lupus ◽  
T Cell Subset

scholarly journals Regulatory T Cell Responses to High-Dose Methylprednisolone in Active Systemic Lupus Erythematosus

PLoS ONE ◽  
2015 ◽  
Vol 10 (12) ◽  
pp. e0143689 ◽  
Author(s):  
Alexis Mathian ◽  
Romain Jouenne ◽  
Driss Chader ◽  
Fleur Cohen-Aubart ◽  
Julien Haroche ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
T Cell ◽  
Lupus Erythematosus ◽  
Regulatory T Cell ◽  
T Cell Responses ◽  
Active Systemic Lupus Erythematosus ◽  
High Dose ◽  
Systemic Lupus ◽  
Cell Responses ◽  
High Dose Methylprednisolone

scholarly journals CD3+CD4+gp130+ T Cells Are Associated With Worse Disease Activity in Systemic Lupus Erythematosus Patients

2021 ◽  
Vol 12 ◽  
Author(s):  
Nur Diyana Mohd Shukri ◽  
Aziz Farah Izati ◽  
Wan Syamimee Wan Ghazali ◽  
Che Maraina Che Hussin ◽  
Kah Keng Wong
Keyword(s):  
Systemic Lupus Erythematosus ◽  
T Cells ◽  
T Cell ◽  
Disease Activity ◽  
Lupus Erythematosus ◽  
Lymphocyte Subpopulations ◽  
Gene Set Enrichment Analysis ◽  
T Cell Subsets ◽  
Healthy Controls ◽  
Systemic Lupus

The receptors for IL-35, IL-12Rβ2 and gp130, have been implicated in the inflammatory pathophysiology of autoimmune diseases. In this study, we set out to investigate the serum IL-35 levels and the surface levels of IL-12Rβ2 and gp130 in CD3+CD4+, CD3+CD4─ and CD3─CD4─ lymphocyte subpopulations in systemic lupus erythematosus (SLE) patients (n=50) versus healthy controls (n=50). The potential T cell subsets associated with gp130 transcript (i.e. IL6ST) expression in CD4+ T cells of SLE patients was also examined in publicly-available gene expression profiling (GEP) datasets. Here, we report that serum IL-35 levels were significantly higher in SLE patients than healthy controls (p=0.038) but it was not associated with SLEDAI-2K scores. The proportions of IL-12Rβ2+ and gp130+ cells in SLE patients did not differ significantly with those of healthy controls in all lymphocyte subpopulations investigated. Essentially, higher SLEDAI-2K scores were positively correlated with increased proportion of gp130+ cells, but not IL-12Rβ2+ cells, on CD3+CD4+ T cells (r=0.425, p=0.002, q=0.016). Gene Set Enrichment Analysis (GSEA) of a GEP dataset of CD4+ T cells isolated from SLE patients (n=8; GSE4588) showed that IL6ST expression was positively associated with genes upregulated in CD4+ T cells vs myeloid or B cells (q<0.001). In an independent GEP dataset of CD4+ T cells isolated from SLE patients (n=9; GSE1057), IL6ST expression was induced upon anti-CD3 stimulation, and that Treg, TCM and CCR7+ T cells gene sets were significantly enriched (q<0.05) by genes highly correlated with IL6ST expression (n=92 genes; r>0.75 with IL6ST expression) upon anti-CD3 stimulation in these SLE patients. In conclusion, gp130 signaling in CD3+CD4+ T cell subsets may contribute to increased disease activity in SLE patients, and it represents a promising therapeutic target for inhibition in the disease.

scholarly journals Detection of Antilymphocyte Antibody with Two-Color Method in Systemic Lupus Erythematosus and Its Heterogeneous Specificities against Human T-Cell Subsets

1979 ◽  
Vol 64 (5) ◽  
pp. 1213-1220 ◽  
Author(s):  
Kunio Okudaira ◽  
Hidenori Nakai ◽  
Tetsuo Hayakawa ◽  
Takamichi Kashiwado ◽  
Kiyoaki Tanimoto ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
T Cell ◽  
Lupus Erythematosus ◽  
T Cell Subsets ◽  
Systemic Lupus ◽  
Human T Cell ◽  
Antilymphocyte Antibody

scholarly journals A defect of immunoregulatory T cell subsets in systemic lupus erythematosus patients demonstrated with anti-2H4 antibody.

1987 ◽  
Vol 79 (3) ◽  
pp. 762-768 ◽  
Author(s):  
C Morimoto ◽  
A D Steinberg ◽  
N L Letvin ◽  
M Hagan ◽  
T Takeuchi ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
T Cell ◽  
Lupus Erythematosus ◽  
T Cell Subsets ◽  
Systemic Lupus

Imbalance between CD8+CD28+ and CD8+CD28– T-cell subsets and its clinical significance in patients with systemic lupus erythematosus

Lupus ◽  
2019 ◽  
Vol 28 (10) ◽  
pp. 1214-1223
Author(s):  
S Minning ◽  
Y Xiaofan ◽  
X Anqi ◽  
G Bingjie ◽  
S Dinglei ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
T Cells ◽  
T Cell ◽  
Lupus Erythematosus ◽  
Fas Ligand ◽  
Activity Index ◽  
Cell Subset ◽  
T Cell Subsets ◽  
Systemic Lupus ◽  
T Cell Subset

Objective The aim of this study was to evaluate the changes in CD8+CD28–/CD8+CD28+ T-cell subset balance and in the CD8+CD28– Treg cell number and function in patients with systemic lupus erythematosus (SLE). Methods Cell isolation and flow cytometry analysis were employed to investigate the T-cell subsets. Results It was found that in high-activity SLE patients, the CD8+CD28+ T-cell subset was reduced, which was inversely correlated with the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI), and that the CD8+CD28–/CD8+CD28+ ratio was elevated, which was positively correlated with SLEDAI and with renal damage and inversely correlated with serum complement level, whereas the CD8+CD28– T-cell subset was increased only in inactive patients. It was also found that apoptosis of CD8+ T cells increased, and Fas, Fas ligand (FasL) and interleukin (IL)-6 expression were high, whereas cytotoxic T-lymphocyte–associated antigen 4 (CTLA-4) expression was low by the CD8+CD28+ T cell subset in active SLE patients; apoptosis was positively correlated with SLEDAI and with the expression of Fas and FasL by the CD8+CD28+ T-cell subset in active SLE patients. IL-6 and CTLA-4 expression were found to be low by the CD8+CD28– T cell subset in active SLE patients. Conclusion These data suggest that high expression of Fas, FasL and IL-6 and low expression of CTLA-4 by the CD8+CD28+ T-cell subset promotes the activation-induced cell death of the CD8+CD28+ T-cell subset, resulting in an imbalance of CD8+CD28–/CD8+CD28+ T cells in active SLE patients, which represents an important feature in the immunological pathogenesis of SLE. The CD8+CD28– T-cell subset may play some role in inactive SLE.

Low-dose interleukin-2 treatment selectively modulates CD4+ T cell subsets in patients with systemic lupus erythematosus

2016 ◽  
Vol 22 (9) ◽  
pp. 991-993 ◽  
Author(s):  
Jing He ◽  
Xia Zhang ◽  
Yunbo Wei ◽  
Xiaolin Sun ◽  
Yaping Chen ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
T Cell ◽  
Lupus Erythematosus ◽  
Low Dose ◽  
Interleukin 2 ◽  
T Cell Subsets ◽  
Cd4 T Cell ◽  
Systemic Lupus
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