scholarly journals The Physiological Role of Thyrotropin-Releasing Hormone in the Regulation of Thyroid-Stimulating Hormone and Prolactin Secretion in the Rat

1978 ◽  
Vol 61 (2) ◽  
pp. 441-448 ◽  
Author(s):  
Arthur R. C. Harris ◽  
Dana Christianson ◽  
M. Susan Smith ◽  
Shih-Lieh Fang ◽  
Lewis E. Braverman ◽  
...  
Keyword(s):  
Physiological Role ◽  
Thyroid Stimulating Hormone ◽  
Prolactin Secretion ◽  
Thyrotropin Releasing Hormone ◽  
Releasing Hormone ◽  
Stimulating Hormone

Physiological role of galanin in the regulation of anterior pituitary function in humans

1994 ◽  
Vol 266 (1) ◽  
pp. E57-E61 ◽  
Author(s):  
A. Giustina ◽  
M. Licini ◽  
M. Schettino ◽  
M. Doga ◽  
G. Pizzocolo ◽  
...  
Keyword(s):  
Anterior Pituitary ◽  
Physiological Role ◽  
Thyroid Stimulating Hormone ◽  
Pituitary Function ◽  
Slight Reduction ◽  
Baseline Serum ◽  
Releasing Hormone ◽  
Anterior Pituitary Function ◽  
Stimulating Hormone

The aim of our study was to elucidate the physiological role of the neuropeptide galanin in the regulation of anterior pituitary function in human subjects. Six healthy men (age range 26-35 yr, body mass index range 20-24 kg/m2) underwent in random order 1) an intravenous bolus injection of growth hormone-releasing hormone (GHRH)-(1-29)-NH2 (100 micrograms) + thyrotropin-releasing hormone (TRH, 200 micrograms) + luteinizing hormone-releasing hormone (LHRH, 100 micrograms) + corticotropin-releasing hormone (CRH, 100 micrograms), and 2) intravenous saline (100 ml) at time 0 plus either human galanin (500 micrograms) in saline (100 ml) or saline (100 ml) from -15 to +30 min. Human galanin determined a significant increase in serum GH (GH peak: 11.3 +/- 2.2 micrograms/l) from both baseline and placebo levels. No significant differences were observed between GH values after galanin and those after GHRH alone (24.3 +/- 5.2 micrograms/l). Human galanin significantly enhanced the GH response to GHRH (peak 49.5 +/- 10 micrograms/l) with respect to either GHRH or galanin alone. Human galanin caused a slight decrease in baseline serum adrenocorticotropic hormone (ACTH; 16.3 +/- 2.4 pg/ml) and cortisol levels (8 +/- 1.5 micrograms/dl). Galanin also determined a slight reduction in both the ACTH (peak 27 +/- 8 pg/ml) and cortisol (peak 13.8 +/- 1.3 micrograms/dl) responses to CRH. Baseline and releasing hormone-stimulated secretions of prolactin, thyroid-stimulating hormone, LH, and follicle-stimulating hormone were not altered by galanin. Our data suggest a physiological role for the neuropeptide galanin in the regulation of GH secretion in humans.(ABSTRACT TRUNCATED AT 250 WORDS)

Thyroid-Stimulating Hormone and Prolactin Responses to Thyrotropin-Releasing Hormone in Common Migraine

Cephalalgia ◽  
1987 ◽  
Vol 7 (4) ◽  
pp. 267-272 ◽  
Author(s):  
Giovanni Murialdo ◽  
Paola Masturzo ◽  
Ugo Filippi ◽  
Diego De Palma ◽  
Daniela Balbi ◽  
...  
Keyword(s):  
Intravenous Administration ◽  
Dose Response ◽  
Thyroid Stimulating Hormone ◽  
Thyrotropin Releasing Hormone ◽  
Healthy Controls ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Releasing Hormone ◽  
The One ◽  
Stimulating Hormone

Intravenous administration of 50 μg or 200 μg thyrotropin-releasing hormone (TRH) to men with common migraine elicited blunted prolactin (PRL) responses, when compared with healthy controls. The thyroid-stimulating hormone (TSH) response was enhanced after 50 μg TRH in the migraineurs, but not after 200 μg. The physiologic TSH dose-response relationship was abolished in migraine sufferers. The data may be interpreted in the light of dopaminergic and noradrenergic supersensitivity, for PRL and TSH, respectively. The TSH response in migraine differs from the one that occurs in depression.

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