scholarly journals Overloading human aortic smooth muscle cells with low density lipoprotein-cholesteryl esters reproduces features of atherosclerosis in vitro.

1977 ◽  
Vol 59 (6) ◽  
pp. 1196-1202 ◽  
Author(s):  
J L Goldstein ◽  
R G Anderson ◽  
L M Buja ◽  
S K Basu ◽  
M S Brown
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Muscle Cells ◽  
Low Density ◽  
Cholesteryl Esters ◽  
Aortic Smooth Muscle Cells ◽  
Aortic Smooth Muscle

Retro-endocytosis of low density lipoprotein by cultured bovine aortic smooth muscle cells

1981 ◽  
Vol 664 (2) ◽  
pp. 255-265 ◽  
Author(s):  
Teresa H. Aulinskas ◽  
Deneys R. Van Der Westhuyzen ◽  
Edwin L. Bierman ◽  
Wieland Gevers ◽  
Gerhard A. Coetzee
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Muscle Cells ◽  
Low Density ◽  
Aortic Smooth Muscle Cells ◽  
Aortic Smooth Muscle

scholarly journals Oxidized Low Density Lipoprotein (LDL) Affects Hyaluronan Synthesis in Human Aortic Smooth Muscle Cells

2013 ◽  
Vol 288 (41) ◽  
pp. 29595-29603 ◽  
Author(s):  
Manuela Viola ◽  
Barbara Bartolini ◽  
Davide Vigetti ◽  
Evgenia Karousou ◽  
Paola Moretto ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Muscle Cells ◽  
Low Density ◽  
Oxidized Low Density Lipoprotein ◽  
Aortic Smooth Muscle Cells ◽  
Aortic Smooth Muscle

Metabolism of cytoplasmic triacylglycerol in cultured aortic smooth muscle cells

1981 ◽  
Vol 59 (8) ◽  
pp. 662-667 ◽  
Author(s):  
O. Stein ◽  
G. A. Coetzee ◽  
Y. Stein
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Muscle Cells ◽  
Cholesterol Content ◽  
Cellular Cholesterol ◽  
Aortic Smooth Muscle Cells ◽  
Aortic Smooth Muscle ◽  
Chase Period

The turnover of cytoplasmic triacylglycerol was studied in cultured rat, rabbit, and bovine aortic smooth muscle cells. Cytoplasmic triacylglycerol was labeled with [3H]glycerol in the presence of oleic acid in the medium and its loss from the cell was studied in the presence of carrier glycerol. Multiple additions of Isuprel or dibutyryl cyclic AMP during the chase period did not enhance the loss of labeled triacylglycerol. The rate of hydrolysis of cellular triacylglycerol was unchanged in the absence or in the presence of 100 μM chloroquine. Modulation of cellular cholesterol content by addition of low density lipoprotein or high density apolipoprotein–sphingomyelin liposomes did not affect the residence time of the cellular triacylglycerol. We conclude that cytoplasmic triacylglycerol in cultured aortic smooth muscle cells is metabolized by an extralysosomal enzyme which is neither catecholamine responsive nor affected by modulation of cellular cholesterol.

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