scholarly journals Effect of increased peritubule protein concentration on proximal tubule reabsorption in the presence and absence of extracellular volume expansion.

1975 ◽  
Vol 55 (3) ◽  
pp. 612-620 ◽  
Author(s):  
C E Ott ◽  
J A Haas ◽  
J L Cuche ◽  
F G Knox
Keyword(s):  
Proximal Tubule ◽  
Volume Expansion ◽  
Protein Concentration ◽  
Extracellular Volume ◽  
Presence And Absence ◽  
Extracellular Volume Expansion

scholarly journals Increased NHE3 abundance and transport activity in renal proximal tubule of rats with heart failure

2012 ◽  
Vol 302 (1) ◽  
pp. R166-R174 ◽  
Author(s):  
Bruna H. Inoue ◽  
Leonardo dos Santos ◽  
Thaissa D. Pessoa ◽  
Ednei L. Antonio ◽  
Bruna P. M. Pacheco ◽  
...  
Keyword(s):  
Heart Failure ◽  
Proximal Tubule ◽  
Volume Expansion ◽  
Extracellular Volume ◽  
Left Ventricular ◽  
Male Rats ◽  
Sodium Reabsorption ◽  
Mrna Levels ◽  
Transport Activity ◽  
Extracellular Volume Expansion

Heart failure (HF) is associated with a reduced effective circulating volume that drives sodium and water retention and extracellular volume expansion. We therefore hypothesized that Na+/H+ exchanger isoform 3 (NHE3), the major apical transcellular pathway for sodium reabsorption in the proximal tubule, is upregulated in an experimental model of HF. HF was induced in male rats by left ventricle radiofrequency ablation. Sham-operated rats (sham) were used as controls. At 6 wk after surgery, HF rats exhibited cardiac dysfunction with a dramatic increase in left ventricular end-diastolic pressure. By means of stationary in vivo microperfusion and pH-dependent sodium uptake, we demonstrated that NHE3 transport activity was significantly higher in the proximal tubule of HF compared with sham rats. Increased NHE3 activity was paralleled by increased renal cortical NHE3 expression at both protein and mRNA levels. In addition, the baseline PKA-dependent NHE3 phosphorylation at serine 552 was reduced in renal cortical membranes of rats with HF. Collectively, these results suggest that NHE3 is upregulated in the proximal tubule of HF rats by transcriptional, translational, and posttranslational mechanisms. Enhanced NHE3-mediated sodium reabsorption in the proximal tubule may contribute to extracellular volume expansion and edema, the hallmark feature of HF. Moreover, our study emphasizes the importance of undertaking a cardiorenal approach to contain progression of cardiac disease.

Role of Oxytocin in the Natriuresis of Extracellular Volume Expansion

1969 ◽  
Vol 130 (4) ◽  
pp. 1276-1279 ◽  
Author(s):  
S. G. Massry ◽  
H. Vorherr ◽  
C. R. Kleeman
Keyword(s):  
Volume Expansion ◽  
Extracellular Volume ◽  
Extracellular Volume Expansion

Extracellular Volume Expansion Caused by Protein Malnutrition in Peritoneal Dialysis Patients with Appropriate Salt and Water Removal

2008 ◽  
Vol 28 (4) ◽  
pp. 407-412 ◽  
Author(s):  
M.-José Fernández-Reyes ◽  
M.-Auxiliadora Bajo ◽  
Gloria del Peso ◽  
Dabaiba Regidor ◽  
Covadonga Hevia ◽  
...  
Keyword(s):  
Peritoneal Dialysis ◽  
Volume Expansion ◽  
Extracellular Volume ◽  
Protein Malnutrition ◽  
Water Removal ◽  
Dialysis Patients ◽  
Extracellular Volume Expansion

scholarly journals Myocardial Extracellular Volume Expansion and the Risk of Recurrent Atrial Fibrillation After Pulmonary Vein Isolation

2014 ◽  
Vol 7 (1) ◽  
pp. 1-11 ◽  
Author(s):  
Tomas G. Neilan ◽  
Francois-Pierre Mongeon ◽  
Ravi V. Shah ◽  
Otavio Coelho-Filho ◽  
Siddique A. Abbasi ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Pulmonary Vein ◽  
Pulmonary Vein Isolation ◽  
Volume Expansion ◽  
Extracellular Volume ◽  
Recurrent Atrial Fibrillation ◽  
Extracellular Volume Expansion

Extracellular volume expansion and delayed resolution of hypertension after canine aortic coarctectomy

Life Sciences ◽  
1983 ◽  
Vol 32 (11) ◽  
pp. 1197-1206
Author(s):  
Curtis G. Wickre ◽  
Gerald M. Baur ◽  
Jan Wong ◽  
Janice Woodruff ◽  
Susan P. Bagby
Keyword(s):  
Volume Expansion ◽  
Extracellular Volume ◽  
Extracellular Volume Expansion
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