scholarly journals Neutral Proteases and Cathepsin D in Human Articular Cartilage

1974 ◽  
Vol 53 (4) ◽  
pp. 1044-1053 ◽  
Author(s):  
Asher I. Sapolsky ◽  
David S. Howell ◽  
J. Frederick Woessner
Keyword(s):  
Articular Cartilage ◽  
Cathepsin D ◽  
Human Articular Cartilage ◽  
Neutral Proteases

scholarly journals Studies on cathepsin B in human articular cartilage

1978 ◽  
Vol 171 (1) ◽  
pp. 149-154 ◽  
Author(s):  
M T Bayliss ◽  
S Y Ali
Keyword(s):  
Articular Cartilage ◽  
Cathepsin B ◽  
Cathepsin D ◽  
Human Articular Cartilage ◽  
Normal Cartilage ◽  
Elderly Individuals ◽  
Age Related ◽  
Hydrolysis Of ◽  
Increased Activity ◽  
Thiol Proteinase

The thiol proteinase cathepsin B (EC 3.4.22.1), previously called cathepsin B1, was assayed in human articular cartilage by its hydrolysis of the synthetic substrate alpha-N-benzoyl-DL-arginine 2-naphthylamide. The enzyme was activated by cysteine and EDTA and completely inhibited by iodoacetamide and HgCl2. It was also partially inhibited by whole human serum. Human osteoarthrotic cartilage had increased activity when compared with normal cartilage. Cathepsin B activity of normal cartilage was age-related, being high in juveniles and declining to low values in adult and elderly individuals. Cathepsin D and cathepsin B both exhibited a zonal variation through the cartilage depth; the surface cells appeared to contain more activity than those close to the subchondral bone.

scholarly journals The Action of Cathepsin D in Human Articular Cartilage on Proteoglycans

1973 ◽  
Vol 52 (3) ◽  
pp. 624-633 ◽  
Author(s):  
Asher I. Sapolsky ◽  
Roy D. Altman ◽  
J. Frederick Woessner ◽  
David S. Howell
Keyword(s):  
Articular Cartilage ◽  
Cathepsin D ◽  
Human Articular Cartilage

scholarly journals Neutral proteases capable of proteoglycan digesting activity in osteoarthritic and normal human articular cartilage

1984 ◽  
Vol 27 (3) ◽  
pp. 305-312 ◽  
Author(s):  
Johanne Martel-Pelletier ◽  
Jean-Pierre Pelletier ◽  
Jean-Marie Cloutier ◽  
David S. Howell ◽  
Latifa Ghandur-Mnaymneh ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Human Articular Cartilage ◽  
Normal Human ◽  
Neutral Proteases

3-D High-Frequency Ultrasound Backscatter Analysis of Human Articular Cartilage

2014 ◽  
Vol 40 (1) ◽  
pp. 244-257 ◽  
Author(s):  
Nils Männicke ◽  
Martin Schöne ◽  
Matthias Gottwald ◽  
Felix Göbel ◽  
Michael L. Oelze ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
High Frequency ◽  
Human Articular Cartilage ◽  
High Frequency Ultrasound ◽  
Ultrasound Backscatter ◽  
Frequency Ultrasound
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