scholarly journals THE METABOLISM OF VARIOUSLY C14-LABELED GLUCOSE IN MAN AND AN ESTIMATION OF THE EXTENT OF GLUCOSE METABOLISM BY THE HEXOSE MONOPHOSPHATE PATHWAY

1961 ◽  
Vol 40 (7) ◽  
pp. 1263-1279 ◽  
Author(s):  
Stanton Segal ◽  
Mones Berman ◽  
Alberta Blair
Keyword(s):  
Glucose Metabolism ◽  
Hexose Monophosphate ◽  
Hexose Monophosphate Pathway

Evidence for the Hexose Monophosphate Pathway for Glucose Metabolism in Human Pancreatic β-Cells

Nature ◽  
1960 ◽  
Vol 185 (4711) ◽  
pp. 468-469 ◽  
Author(s):  
JAMES B. FIELD ◽  
PHYLLIS JOHNSON ◽  
BETTY HERRING ◽  
ARNOLD N. WEINBERG
Keyword(s):  
Glucose Metabolism ◽  
Hexose Monophosphate ◽  
Β Cells ◽  
Pancreatic Β Cells ◽  
Hexose Monophosphate Pathway

scholarly journals Effect of dithiocyano-methane on hexose monophosphate pathway in the respiratory metabolism of Escherichia coli

AMB Express ◽  
2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Yanfeng Chen ◽  
Wenjie Ke ◽  
Huabin Qin ◽  
Siwei Chen ◽  
Limei Qin ◽  
...  
Keyword(s):  
Gene Expression ◽  
Escherichia Coli ◽  
Control Group ◽  
Respiratory Metabolism ◽  
Hexose Monophosphate ◽  
Hexose Monophosphate Pathway ◽  
Response To Stress ◽  
Glucose Decomposition ◽  
Decomposition Pathway ◽  
Glucose 6 Phosphate Dehydrogenase

Abstract This paper studied the inhibitory effects of dithiocyano-methane (DM) on the glucose decomposition pathway in the respiratory metabolism of Escherichia coli. We investigated the effects of DM on the activities of key enzymes (ATPase and glucose-6-phosphate dehydrogenase, G6PDH), the levels of key product (nicotinamide adenosine denucleotide hydro-phosphoric acid, NADPH), and gene expression in the hexose monophosphate pathway (HMP). The results showed that the minimum inhibitory concentration (MIC) and the minimum bactericide concentration (MBC) of DM against the tested strains were 5.86 mg/L and 11.72 mg/L, respectively. Bacteria exposed to DM at MIC demonstrated an increase in bacterial ATPase and G6PDH activities, NADPH levels, and gene expression in the HMP pathway compared to bacteria in the control group, which could be interpreted as a behavioral response to stress introduced by DM. However, DM at a lethal concentration of 10 × MIC affected glucose decomposition by inhibiting mainly the HMP pathway in E. coli.

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