scholarly journals SUSCEPTIBILITY OF RATS TO EXPERIMENTAL PYELONEPHRITIS FOLLOWING RECOVERY FROM POTASSIUM DEPLETION*†

1960 ◽  
Vol 39 (1) ◽  
pp. 28-33 ◽  
Author(s):  
James W. Woods ◽  
Louis G. Welt ◽  
Walter Hollander ◽  
Margaret Newton
Keyword(s):  
Potassium Depletion ◽  
Experimental Pyelonephritis

scholarly journals SUSCEPTIBILITY OF RATS TO EXPERIMENTAL PYELONEPHRITIS DURING POTASSIUM DEPLETION*

1961 ◽  
Vol 40 (3) ◽  
pp. 599-602 ◽  
Author(s):  
James W. Woods ◽  
Louis G. Welt ◽  
Walter Hollander
Keyword(s):  
Potassium Depletion ◽  
Experimental Pyelonephritis

scholarly journals Effects of potassium depletion on renal tubular chloride transport in the rat

1978 ◽  
Vol 14 (5) ◽  
pp. 414-427 ◽  
Author(s):  
Robert G. Luke ◽  
Fred S. Wright ◽  
Nicole Fowler ◽  
Michael Kashgarian ◽  
Gerhard H. Giebisch
Keyword(s):  
Chloride Transport ◽  
Potassium Depletion ◽  
Renal Tubular

The role of antibody in experimental pyelonephritis

1969 ◽  
Vol 97 (3) ◽  
pp. 513-525 ◽  
Author(s):  
Michael Kyriakos ◽  
Norman S. Ikari
Keyword(s):  
Experimental Pyelonephritis

Potassium depletion improves myocardial potassium uptake in vivo

2004 ◽  
Vol 287 (1) ◽  
pp. C135-C141 ◽  
Author(s):  
Henning Bundgaard
Keyword(s):  
Uptake Rate ◽  
High Plasma ◽  
Potassium Depletion ◽  
Uptake Capacity ◽  
K Uptake ◽  
Impulse Generation ◽  
Uptake Rates ◽  
Clinical Interest ◽  
A Minor

Potassium depletion (KD) is a very common clinical entity often associated with adverse cardiac effects. KD is generally considered to reduce muscular Na-K-ATPase density and secondarily reduce K uptake capacity. In KD rats we evaluated myocardial Na-K-ATPase density, ion content, and myocardial K reuptake. KD for 2 wk reduced plasma K to 1.8 ± 0.1 vs. 3.5 ± 0.2 mM in controls ( P < 0.01, n = 7), myocardial K to 80 ± 1 vs. 86 ± 1 μmol/g wet wt ( P < 0.05, n = 7), increased Mg, and induced a tendency to increased Na. Myocardial Na-K-ATPase α2-subunit abundance was reduced by ∼30%, whereas increases in α1- and K-dependent pNPPase activity of 24% ( n = 6) and 13% ( n = 6), respectively, were seen. This indicates an overall upregulation of the myocardial Na-K pump pool. KD rats tolerated a higher intravenous KCl dose. KCl infusion until animals died increased myocardial K by 34% in KD rats and 18% in controls ( P < 0.05, n = 6 for both) but did not induce different net K uptake rates between groups. However, clamping plasma K at ∼5.5 mM by KCl infusion caused a higher net K uptake rate in KD rats (0.22 ± 0.04 vs. 0.10 ± 0.03 μmol·g wet wt−1·min−1; P < 0.05, n = 8). In conclusion, a minor KD-induced decrease in myocardial K increased Na-K pump density and in vivo increased K tolerance and net myocardial K uptake rate during K repletion. Thus the heart is protected from major K losses and accumulates considerable amounts of K during exposure to high plasma K. This is of clinical interest, because a therapeutically induced rise in myocardial K may affect contractility and impulse generation-propagation and may attenuate increased myocardial Na, the hallmark of heart failure.

TOTAL BODY CHLORIDE IN TUBERCULOUS MENINGITIS

PEDIATRICS ◽  
1954 ◽  
Vol 14 (2) ◽  
pp. 87-92
Author(s):  
DONALD B. CHEEK
Keyword(s):  
Tuberculous Meningitis ◽  
Metabolic Alkalosis ◽  
Extracellular Fluid ◽  
Fluid Restriction ◽  
Potassium Depletion ◽  
Water Excretion ◽  
Serum Chloride ◽  
The Status ◽  
Total Body

Seven children with tuberculous meningitis have been studied. In the absence of fluid restriction and vomiting, hypotonic expansion of the extracellular fluid has been revealed. This draws attention to an alteration in water excretion. Metabolic alkalosis yields evidence of cell potassium depletion. The serum chloride is no indication as to the status of total body chloride.

scholarly journals Expression of rat thick limb Na/H exchangers in potassium depletion and chronic metabolic acidosis

2001 ◽  
Vol 60 (4) ◽  
pp. 1386-1396 ◽  
Author(s):  
Kamel Laghmani ◽  
Christine Richer ◽  
Pascale Borensztein ◽  
Michel Paillard ◽  
Marc Froissart
Keyword(s):  
Metabolic Acidosis ◽  
Potassium Depletion ◽  
Chronic Metabolic Acidosis
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