scholarly journals The Role of Anaerobic Metabolism in the Performance of Mild Muscular Work. II. The Effect of Asymptomatic Heart Disease1

1958 ◽  
Vol 37 (11) ◽  
pp. 1593-1602 ◽  
Author(s):  
William E. Huckabee
1979 ◽  
Vol 47 (4) ◽  
pp. 701-705 ◽  
Author(s):  
J. M. Pequignot ◽  
L. Peyrin ◽  
M. H. Mayet ◽  
R. Flandrois

The urinary excretion of dihydroxyphenylalanine (DOPA), catecholamines (CA) [dopamine (DA), norepinephrine (NE), and epinephrine (e)], their 3-O-methylated derivatives [3-O-methyldopamine (3-MT), normetanephrine (NMN), and metanephrine (MN)], and their deaminated metabolites [dihydroxyphenylacetic acid (DOPAC) and vanilmandelic acid (VMA)] was studied in six healthy men, at rest during short-term (15 min) or exhaustive submaximal exercise, and in the 2-h postexercise recovery period. During short-term exercise only NE and VMA excretions increased, whereas in postexercise period only DA output was enhanced. Exhaustive muscular work induced a rise in NE and E excretion during the test, and an increase in DA, NE, and NMN urinary levels during postexercise recovery, while the output of deaminated metabolites was unaltered. It is concluded that both release and synthesis of CA are stimulated by submaximal exercise, which induces, in addition to NE, a specific release of DA. A possible role of NE in lipid mobilization during recovery from exhaustive muscular work is evoked. The origin and role of released DA are also discussed.


2021 ◽  
Vol 71 (4) ◽  
pp. 158-160
Author(s):  
Arifah Nur Shadrina ◽  
Irene Yuniar

Shock in children remains public health importance and causes significant morbidity and mortality worldwide. Hypoperfusion in shock results in decreased oxygen delivery to the tissues, causing a shift from more efficient aerobic pathways to anaerobic metabolism, which results in lactate as the end product. Unlike blood lactate measurement, near-infrared spectroscopy (NIRS) monitoring system is safe and easy to use in measuring tissue oxygenation non-invasively. However, NIRS monitoring has yet to be validated against a standard measure of regional oxygenation. The primary objective of this article is to review the role of cerebral oxygen saturation (rSO2) measured by NIRS in evaluating the outcome of pediatric shock resuscitation.


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