scholarly journals THE EFFECT OF SALICYLATES ON THE ELECTROLYTE STRUCTURE OF THE BLOOD PLASMA. II. THE ACTION OF THERAPEUTIC DOSES OF SODIUM SALICYLATE AND OF ACETYLSALICYLIC ACID IN MAN1

1945 ◽  
Vol 24 (5) ◽  
pp. 770-774 ◽  
Author(s):  
George M. Guest ◽  
S. Rapoport ◽  
C. Roscoe
Keyword(s):  
Acetylsalicylic Acid ◽  
Blood Plasma ◽  
Sodium Salicylate ◽  
Therapeutic Doses

scholarly journals INFLUENCE OF SODIUM SALICYLATE UPON THE ARTHRITIS OF RABBITS INOCULATED WITH NON-HEMOLYTIC STREPTOCOCCI

1923 ◽  
Vol 37 (4) ◽  
pp. 553-584 ◽  
Author(s):  
Homer F. Swift ◽  
Ralph H. Boots
Keyword(s):  
Sodium Salicylate ◽  
The Other ◽  
Other Hand ◽  
Anti Inflammatory ◽  
Therapeutic Doses ◽  
Inflammatory Action

1. Rabbits inoculated intravenously with non-hemolytic streptococci, while under the influence of full therapeutic doses of sodium salicylate, developed almost as many inflamed joints as the untreated controls similarly inoculated. 2. The salicylated rabbits, on the other hand, had a much higher proportion of mildly inflamed Joints than did the controls. 3. This anti-inflammatory action was most evident in the animals inoculated with streptococci of the lowest virulence, and could not be demonstrated in animals inoculated with hemolytic streptococci.

scholarly journals Analysis of Pharmacokinetic Parameters of Acetylsalicylic Acid for Prediction of Potential Nephrotoxic Effects

2021 ◽  
Vol 9 (4) ◽  
pp. 209-215
Author(s):  
L. M. Krasnykh ◽  
O. A. Goroshko ◽  
G. F. Vasilenko ◽  
G. I. Gorodetskaya ◽  
V. V. Smirnov ◽  
...  
Keyword(s):  
Salicylic Acid ◽  
Acetylsalicylic Acid ◽  
Blood Plasma ◽  
Maximum Concentration ◽  
Test Procedure ◽  
Elimination Rate ◽  
Statistical Processing ◽  
Apparent Volume ◽  
Pharmacokinetic Parameters ◽  
In Blood Plasma

Nonsteroidal anti-inflammatory drugs, including acetylsalicylic acid, can have a dose-dependent nephrotoxic effect. The study of the pharmacokinetics of acetylsalicylic acid products will contribute to timely detection and correction of side effects caused by this medicinal product.The aim of the study was to evaluate potential nephrotoxic effects following a single oral administration of 75 mg of acetylsalicylic acid, based on the analysis of the pharmacokinetic parameters.Materials and methods: the study involved 24 healthy volunteers who received 75 mg of acetylsalicylic acid (tablets) once orally. The measurement of the active metabolite of acetylsalicylic acid—salicylic acid—in blood plasma was performed by HPLC/MS using an Agilent 1200 liquid chromatography system coupled to an Agilent 6140 tandem mass spectrometer. Agilent Eclipse XDB-C18 column (4.6 mm×150 mm; 5.0 μm) was used for chromatographic separation. The test procedure used in the study was validated. The results obtained were used to calculate the pharmacokinetic parameters: Cmax (maximum concentration), Tmax (time to maximum concentration), T1/2 (half-life of the drug), AUC0-t (area under the pharmacokinetic curve from 0 to the last time point of the curve), AUC0-∞ (total area under the pharmacokinetic curve from 0 to ∞), MRT (mean residence time of the drug in the blood), Kel (elimination rate constant), Cl/F (total clearance), Vd/F (apparent volume of distribution). The Statistics (22.0.0.0) software was used for statistical processing of the results.Results: T1/2 of salicylic acid in blood plasma was determined to be 1.6 ± 0.5 h, Cmax was 4523.0 ± 725.0 ng/mL, and Tmax was 0.98 ± 0.4 h. AUC0–t was equal to 16183.0 ± 3823.0 ng×h/m, Vd/F was 12.0 ± 3.1 L/kg, and MRT was 2.9 ± 0.6 h.Conclusions: the analysis of the pharmacokinetic parameters demonstrated a high absorption rate, intensive distribution, and moderate elimination rate of salicylic acid (the main metabolite of acetylsalicylic acid), indicating a low risk of nephrotoxic effects associated with the studied dose of the drug.

Effect of antipyretic drugs on circadian rhythm in body temperature of rats

1987 ◽  
Vol 253 (2) ◽  
pp. R306-R313 ◽  
Author(s):  
W. E. Scales ◽  
M. J. Kluger
Keyword(s):  
Circadian Rhythm ◽  
Body Temperature ◽  
Acetylsalicylic Acid ◽  
Sodium Salicylate ◽  
Prostaglandin Synthesis ◽  
Plateau Phase ◽  
Considerable Evidence ◽  
Set Point ◽  
Significant Fall ◽  
Prostaglandin Synthesis Inhibitors

In many species, including the laboratory rat, body temperature varies on a circadian (24 h) basis. There is considerable evidence that the circadian rise in body temperature is attributable to an elevation in thermoregulatory set point. We hypothesized that this rise in set point may be mediated by prostaglandins. If this hypothesis is correct, then it should be possible to block or reduce the nighttime rise in body temperature by the administration of prostaglandin synthesis inhibitors. Rats were injected with the prostaglandin synthesis inhibitors sodium salicylate, acetylsalicylic acid, and indomethacin at 5:00 P.M. and at 9:00 A.M. Administration of these drugs had little effect on body temperature during the day but caused a significant fall in body temperature at night when temperature is normally in the rising or plateau phase of the cycle. We conclude that prostaglandin synthesis is an important component of the circadian rise in body temperature in the rat. In addition, evidence is presented that there exists a cryogenic factor that opposes the nighttime prostaglandin-mediated rise in body temperature.

Comparative pharmacokinetics of acetylsalicylic acid and sodium salicylate in chickens and turkeys

2013 ◽  
Vol 54 (4) ◽  
pp. 538-544 ◽  
Author(s):  
B. Poźniak ◽  
M. Świtała ◽  
K. Jaworski ◽  
P. Okoniewski ◽  
P. Niewiński
Keyword(s):  
Acetylsalicylic Acid ◽  
Sodium Salicylate

Adverse effects associated with high-dose acetylsalicylic acid and sodium salicylate treatment in broilers

2012 ◽  
Vol 53 (6) ◽  
pp. 777-783 ◽  
Author(s):  
B. Poźniak ◽  
M. Świtała ◽  
K. Bobrek ◽  
S. Graczyk ◽  
S. Dzimira
Keyword(s):  
Adverse Effects ◽  
Acetylsalicylic Acid ◽  
Sodium Salicylate ◽  
High Dose
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