scholarly journals THE DAILY URINARY EXCRETION OF ESTROGENIC AND ANDROGENIC SUBSTANCES BY NORMAL MEN AND WOMEN 1

1937 ◽  
Vol 16 (5) ◽  
pp. 695-703 ◽  
Author(s):  
T. F. Gallagher ◽  
D. H. Peterson ◽  
R. I. Dorfman ◽  
A. T. Kenyon ◽  
F. C. Koch
Keyword(s):  
Urinary Excretion ◽  
Men And Women ◽  
Normal Men

Circadian rhythms of 6-sulphatoxy melatonin, cortisol and electrolyte excretion at the summer and winter solstices in normal men and women

1986 ◽  
Vol 113 (3) ◽  
pp. 450-456 ◽  
Author(s):  
D.J. Kennaway ◽  
P. Royles
Keyword(s):  
Circadian Rhythms ◽  
Urinary Excretion ◽  
Sodium Excretion ◽  
Animal Species ◽  
Normal Subjects ◽  
Electrolyte Excretion ◽  
Urinary Cortisol ◽  
Men And Women ◽  
Urinary Cortisol Excretion ◽  
Normal Men

Abstract. Urinary excretion of 6-suphatoxy melatonin, cortisol, potassium and sodium was monitored at four hourly intervals for 24 h in 30 normal subjects at the summer and winter solstices. The 24 h profiles were fitted to sine curves and mean 24-h excretion, time of maximum excretion and amplitude of the curves compared. The excretion of 6-sulphatoxy melatonin was remarkably stable at the two times of the year (24-h excretion 108 ± 6.3 nmol in summer and 105 ± 6.3 nmol in winter, mean ± sem). The time of maximum excretion was significantly delayed in winter by 1 h and 40 min. Urinary cortisol excretion was significantly higher in winter, however, the amplitude was unaltered. The time of maximum excretion of cortisol was significantly delayed by 1 h and 34 min. Potassium and sodium excretion were both unaffected by seasonal influences. These results contrast with results in some animal species in which the duration of the melatonin signal is thought to be the key determinant in subsequent melatonin action. In humans it is likely that the phasing of the melatonin rhythm is of prime importance.

scholarly journals Urinary Excretion of Erythropoietin in Normal Men and Women

Blood ◽  
1966 ◽  
Vol 28 (3) ◽  
pp. 344-353 ◽  
Author(s):  
RAYMOND ALEXANIAN ◽  
Brenda Prewitt
Keyword(s):  
Urinary Excretion ◽  
Dose Response ◽  
Normal Subjects ◽  
Adult Males ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Men And Women ◽  
Linear Dose ◽  
Prepubertal Boys ◽  
Normal Men

Abstract The bioassay of erythropoietin in polycythemic mice was modified to include a protein-depletion diet and a divided erythropoietin injection schedule. Although less than 0.05 unit of standard erythropoietin was not detected, a more linear dose/response relationship resulted from increasing doses of erythropoietin in the 0.1 to 1.0 unit range. The amount of erythropoietin in concentrated specimens prepared from the 24-hour urinary excretion of 25 normal subjects was measured in comparison with known quantities of standard erythropoietin. A mean daily erythropoietin excretion in men of 2.8 ± 1.3 units, in women of 0.9 ± 0.4 unit and in prepubertal boys of 1.0 unit was calculated. The higher erythropoietin excretion in adult males may be secondary to a greater production of erythropoietin in this sex.

ÉTUDES IN VIVO SUR LE MÉTABOLISME DES ANDROGÉNES APRES ADMINISTRATION DE STÉROÏDES INHIBITEURS DE L'OVULATION

1965 ◽  
Vol 50 (1) ◽  
pp. 131-144 ◽  
Author(s):  
P. Mauvais-Jarvis ◽  
M. F. Jayle ◽  
J. Decourt ◽  
J. Louchart ◽  
J. Truffert
Keyword(s):  
Luteinizing Hormone ◽  
Urinary Excretion ◽  
Normal Subjects ◽  
Hormone Activity ◽  
Testosterone Production ◽  
Normal Men ◽  
Ethinyl Oestradiol

ABSTRACT Normal subjects and hirsute women with micropolycystic ovaries were treated with ethinyl-oestrenol + 3-methoxy-ethinyl-oestradiol (Lyndiol®), in view of studying the action of this compound on the production of androgens and on the urinary excretion of their metabolites. In normal men, the production of testosterone and the excretion of androsterone and aetiocholanolone are suppressed, whereas the excretion of other 17-ketosteroids and the production of dehydroepiandrosterone sulphate are unchanged. Moreover, the luteinizing hormone activity (LH) in plasma is depressed. It seems that the preparation inhibits specifically the testicular androgen production, by suppressing the hypothalamo-hypophyseal control of LH. Testosterone production and urinary 17-ketosteroid excretion are modified in the same way in women with Stein-Leventhal's syndrome. Physiopathological and therapeutical implications which come from these results are discussed.

Hysterical traits and variability of mood in normal men

1979 ◽  
Vol 9 (2) ◽  
pp. 301-304 ◽  
Author(s):  
Peter V. Rabins ◽  
Phillip R. Slavney
Keyword(s):  
Men And Women ◽  
Normal Women ◽  
Normal Men

SynopsisIn a study of 40 normal men it was found that self-ratings on variability of mood were positively correlated with self-ratings on hysterical traits. These results are similar to those found in normal women and lend support both to the validity of the concept of hysterical personality and to the idea that men and women experience fluctuations of mood in a similar way.

Differences in insulin sensitivity between normal men and women

Metabolism ◽  
1985 ◽  
Vol 34 (12) ◽  
pp. 1133-1138 ◽  
Author(s):  
Peter J. Hale ◽  
John V. Wright ◽  
Malcolm Nattrass
Keyword(s):  
Insulin Sensitivity ◽  
Men And Women ◽  
Normal Men

THE ESTIMATION OF 3α-HYDROXY-5α-ANDROST-16-ENE AND OTHER C19-Δ16-STEROIDS IN URINE BY GAS-LIQUID CHROMATOGRAPHY

1970 ◽  
Vol 63 (1) ◽  
pp. 79-90 ◽  
Author(s):  
B. W. L. Brooksbank ◽  
D. B. Gower
Keyword(s):  
Liquid Chromatography ◽  
Excretion Rate ◽  
Quantitative Estimation ◽  
Colorimetric Method ◽  
Gas Liquid Chromatography ◽  
Urinary Excretion Rate ◽  
Men And Women ◽  
Accuracy And Precision ◽  
Preliminary Purification ◽  
Normal Men

ABSTRACT A method is described for the quantitative estimation of C19-Δ16-steroids in human urine. After extraction and preliminary purification by the method of Brooksbank & Haslewood (1961), the steroids were analyzed as chloromethyl dimethylsilyl ethers by gas-liquid chromatography. The specificity, accuracy and precision of the method were found to be satisfactory and comparison with the colorimetric method of Brooksbank & Haslewood (1961) for urinary 3α-hydroxy-5α-androst-16-ene showed a high correlation coefficient, r = 0.97 (P < 0.001). Figures are given for the urinary excretion rate of 3α-hydroxy-5α-androst-16-ene of normal men and women and of some women suffering from hirsutism and from adrenocortical overactivity. The values are given for 3α-hydroxy-5β-androst-16-ene and 3β-hydroxyandrosta-5,16-diene in pools of urine from healthy men and women.

A more specific, liquid-chromatographic method for free cortisol in urine.

1982 ◽  
Vol 28 (12) ◽  
pp. 2418-2420 ◽  
Author(s):  
E Canalis ◽  
G E Reardon ◽  
A M Caldarella
Keyword(s):  
Present Method ◽  
Chromatographic Method ◽  
Urinary Cortisol ◽  
Men And Women ◽  
Coefficients Of Variation ◽  
Liquid Chromatographic Method ◽  
Analytical Recovery ◽  
Free Cortisol ◽  
Normal Men ◽  
Liquid Chromatographic

Abstract Currently used assays for urinary cortisol reportedly overestimate it, owing to cross-reacting substances. We describe here a method for separating and measuring by liquid chromatography cortisol extracted from urine. The method is specific for cortisol and as little as 5 ng per sample can be measured. Mean analytical recovery of added cortisol was 98.8% (SD 6.1%) and the coefficients of variation ranged from 3.1 to 4.7% (within-day) and from 7.1 to 14% (between-day). Mean (and SD) urinary excretion of cortisol for 45 normal men and women was 20.1 (SD 7.6) micrograms/24 h; for 29 children it was 14.1 (SD 6.0) micrograms/24 h. Results by radioimmunoassay were 1.4- to 4.3-fold greater than by this method, and results of the two assays did not correlate well (r = 0.59, p less than 0.01). We consider the present method to be a practical and specific assay for three cortisol in urine.

Comparison of effects of sustained isocapnic hypoxia on ventilation in men and women

1997 ◽  
Vol 83 (2) ◽  
pp. 599-607 ◽  
Author(s):  
Dimitar Sajkov ◽  
Alister Neill ◽  
Nicholas A. Saunders ◽  
R. Douglas McEvoy
Keyword(s):  
Menstrual Cycle ◽  
Minute Ventilation ◽  
Premenopausal Women ◽  
Follicular Phase ◽  
Inspiratory Time ◽  
Men And Women ◽  
Ventilatory Responses ◽  
Reduced Frequency ◽  
Normal Men ◽  
Respiratory Depressant

Sajkov, Dimitar, Alister Neill, Nicholas A. Saunders, and R. Douglas McEvoy. Comparison of the effects of sustained isocapnic hypoxia on ventilation in men and women. J. Appl. Physiol. 83(2): 599–607, 1997.—Sleep-related respiratory disturbances are more common in men than in premenopausal women. This might, in part, be due to different susceptibilities to the respiratory depressant effects of hypoxia. Therefore, we compared ventilation during 10 min of baseline room-air breathing and 20-min sustained isocapnic hypoxia (fractional inspired O2 = 11%, arterial saturation of O2 ≈ 80%) followed by 10 min of breathing 100% O2 in 10 normal men and in 10 women in the follicular phase of the menstrual cycle. Control measurements were made during two transitions from room air (10 min) to 100% O2 (10 min) and averaged. Inspired minute ventilation (V˙i) after 2 min of hypoxia was the same in men and women [131 ± 6.1% baseline for men, 136 ± 7.7% baseline for women; not significant (NS)] and declined to the same level after 20 min (115 ± 5.0% baseline for men, 116 ± 6.6% baseline for women; NS) associated with a similar decline in inspiratory time and tidal volume. Breathing frequency did not change.V˙i decreased transiently during subsequent 100% O2 breathing in both men and women, associated with reduced frequency and duty cycle and increased expiratory time. The fall inV˙i was significantly greater than that observed during control hyperoxia experiments in men but not in women. We conclude that ventilatory responses to sustained isocapnic hypoxia do not differ between awake healthy men and women in the follicular phase of their menstrual cycle. However, after termination of isocapnic hypoxia, men appear to depress their ventilation to a greater degree than women.

Individual Variation in Serum Calcium in Normal Men and Women.

1931 ◽  
Vol 28 (9) ◽  
pp. 907-913 ◽  
Author(s):  
R. E. Boynton ◽  
E. M. Greisheimer
Keyword(s):  
Serum Calcium ◽  
Individual Variation ◽  
Men And Women ◽  
Normal Men

Differential effects of a dopaminergic drug (piribedil) on pituitary hormone release in normal men and women

1983 ◽  
Vol 104 (4) ◽  
pp. 385-389 ◽  
Author(s):  
Laura De Marinis ◽  
Antonio Mancini ◽  
Francesco Calabrò ◽  
Michele Massari ◽  
Massimo Torlontano ◽  
...  
Keyword(s):  
Dopamine Receptor Agonist ◽  
Pituitary Hormone ◽  
Hormone Release ◽  
Men And Women ◽  
Differential Effects ◽  
Anterior Pituitary Hormone ◽  
Sexual Steroid ◽  
Dopaminergic Tone ◽  
Normal Women ◽  
Normal Men

Abstract. Six normal women, in the follicular phase of their menstrual cycle, and 6 normal men received orally 40, 60 and 100 mg doses of piribedil, a dopamine receptor agonist, or placebo. The effects of piribedil on anterior pituitary hormone release was evaluated. In normal women a dose-related decrease in Prl levels was observed, while in men the Prl decrement was not related to the dose employed. In women an increase in serum hGH occurred after administration of the lowest (40 mg) dose of piribedil. In normal men, on the contrary, a modest hGH stimulation was present after administration of all doses of the drug. No consistent changes in serum TSH, LH and FSH concentrations were observed and no side effects were reported. The results from this study indicate that piribedil can exert differential effects on hypophyseal trophic hormone release and that these effects are sex-related. It is possible that the differences observed in men and women after the administration of piribedil are due to a different endogenous dopaminergic tone, induced by the different sexual steroid environment.

Sign in / Sign up

Export Citation Format

Share Document