scholarly journals EXPERIMENTAL ANEMIA PRODUCED BY PHENYL-HYDRAZINE DERIVATIVES

1926 ◽  
Vol 2 (4) ◽  
pp. 329-342 ◽  
Author(s):  
Perrin H. Long
Keyword(s):  
Phenyl Hydrazine ◽  
Hydrazine Derivatives

Synthesis of 4-(5-Aryl-1,3,4-oxadiazol-2-yl)phenyl-hydrazine Derivatives from 3-(4-Hydrazinocarbonyl-phenyl)sydnones.

ChemInform ◽  
2007 ◽  
Vol 38 (37) ◽  
Author(s):  
Hung-Te Chang ◽  
Kuo-Chen Chiang ◽  
Fung Fuh Wong ◽  
Chun-Sheng Huang ◽  
Yang-Ming Liao ◽  
...  
Keyword(s):  
Phenyl Hydrazine ◽  
Hydrazine Derivatives

Synthesis of 4-(5-aryl-1,3,4-oxadiazol-2-yl)phenyl-hydrazine derivatives from 3-(4-hydrazinocarbonyl-phenyl)sydnones

2007 ◽  
Vol 18 (4) ◽  
pp. 438-442 ◽  
Author(s):  
Hung-Te Chang ◽  
Kuo-Chen Chiang ◽  
Fung Fuh Wong ◽  
Chun-Sheng Huang ◽  
Yang-Ming Liao ◽  
...  
Keyword(s):  
Phenyl Hydrazine ◽  
Hydrazine Derivatives

The Mechanism of Erythroblast Denucleation

1967 ◽  
Vol 25 ◽  
pp. 48-49
Author(s):  
Charles F. Simpson ◽  
J. W. Carlisle ◽  
J. M. Kling
Keyword(s):  
Babesia Canis ◽  
Phenyl Hydrazine ◽  
Principal Mechanism

It is not known whether loss of nuclei from erythroblasts occurs by extrusion or by karyolysis, or both. In this study, blood from anemic dogs was utilized. Dogs were anemic as a result of severe parasitism with a hematozoic parasite, Babesia canis, or were made anemic by treating them with phenyl hydrazine hydrochloride.The mechanism of denucleation was the same in both types of anemia investigated. It was found that extrusion was the principal mechanism of denucleation from the erythroblast. However, probably karyolysis also occurred occasionally, prior to extrusion.

Synthesis and Antibacterial Screening of Some Pyrazole Derivatives Catalyzed by Cetyltrimethylammoniumbromide (CTAB)

2020 ◽  
Vol 17 ◽  
Author(s):  
Ravi Bansal ◽  
Pradeep K. Soni ◽  
Neha Gupta ◽  
Sameer S. Bhagyawant ◽  
Anand K. Halve
Keyword(s):  
Hydrazine Hydrate ◽  
Ethyl Acetoacetate ◽  
Aromatic Aldehydes ◽  
Pyrazole Derivatives ◽  
Phenyl Hydrazine ◽  
One Pot ◽  
Antibacterial Screening ◽  
Water As Solvent ◽  
Substituted Pyrazoles ◽  
Sulfinic Esters

Aims: In this article we have developed an eco-friendly one-pot multi-component reaction methodology was employed for the green synthesis of functionalized pyrazole derivatives viz cyclo-condensation of aromatic aldehydes, ethyl acetoacetate and phenyl hydrazine and/or hydrazine hydrate in the presence of cetyltrimethylammoniumbromide (CTAB) at 90°C temperature in aqueous medium. Method: In the present protocol we developed a green method for the synthesis of functionalized pyrazole derivatives through one-pot, multi-component cyclo-condensation of aromatic aldehydes, phenyl hydrazine or hydrazine hydrate and ethyl acetoacetate using cetyltrimethylammoniumbromide (CTAB) as a catalyst in water as solvent. Our methodology confers advantages such as short reaction time, atom economy, purification of product without using column chromatographic and hazardous solvent. The reaction is being catalyzed by cetyltrimethylammoniumbromide (CTAB) and thus products are formed under the green reaction conditions. Results: Initially the reaction of benzaldehyde and phenylhydrazine with ethyl acetoacetate was carried out in water at room temperature in the absence of the catalyst; no product was obtained after 24 h (Table 1 entry 1). When the reaction was carried out using L-proline as catalyst in ethanol at 70°C the yield of product was 20. Conclusion: This research not only provides a green and efficient method for the synthesis of sulfinic esters but also shows new applications of electrochemistry in organic synthesis. We consider that this green and efficient synthetic protocol used to prepare sulfinic esters will have good applications in future. In conclusion, we have developed successfully a green and efficient one-pot multi-component methodology for the synthesis of substituted pyrazoles using CTAB as a catalyst in water as solvent with excellent yields. Purifications of compounds were achieved without the use of traditional chromatographic procedures. This methodology has advantages of operational simplicity, clean reaction profiles and relatively broad scope which make it more attractive for the diversity oriented synthesis of these heterocyclic libraries. In this methodology we suggest the further alternative possibility for formation of substituted pyrazoles. The compound 7h can be used as an anticancer drug in pharma industry.

scholarly journals A Facile Synthesis and Studies of Some New Chalcones and Their Derivatives Based on Heterocyclic Ring

2012 ◽  
Vol 9 (4) ◽  
pp. 1897-1905 ◽  
Author(s):  
A. Solankee ◽  
K. Patel ◽  
R. Patel
Keyword(s):  
Inhibitory Concentration ◽  
Guanidine Hydrochloride ◽  
Heterocyclic Ring ◽  
Dilution Method ◽  
Facile Synthesis ◽  
Phenyl Hydrazine ◽  
Gram Negative ◽  
E Coli ◽  
Heterocyclic Aldehydes ◽  
Broth Dilution

Chalcones(6a-f)have been prepared by the condensation of ketone(5)and different aromatic and heterocyclic aldehydes. These chalcones(6a-f)on treatment with guanidine hydrochloride and phenyl hydrazine hydrochloride in presence of alkali give aminopyrimidines(7a-f)and phenylpyrazolines(8a-f)respectively. All the newly synthesized compounds have been characterized on the basis of IR,1HNMR spectral data as well as physical data. Antibacterial activity (minimum inhibitory concentration MIC) against Gram-positiveS. aureusMTCC 96 andS. pyogeneusMTCC 442 and Gram-negativeP. aeruginosaMTCC 1688 andE. coliMTCC 443 bacteria, as well as antifungal acivities (MIC) againstC. albicansMTCC 227,A. nigerMTCC 282 andA. clavatusMTCC 1323 were determined by broth dilution method.

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