scholarly journals Leydig cell–derived heme oxygenase-1 regulates apoptosis of premeiotic germ cells in response to stress

2002 ◽  
Vol 109 (4) ◽  
pp. 457-467 ◽  
Author(s):  
Nobuaki Ozawa ◽  
Nobuhito Goda ◽  
Nobuya Makino ◽  
Tokio Yamaguchi ◽  
Yasunori Yoshimura ◽  
...  
Keyword(s):  
Heme Oxygenase ◽  
Germ Cells ◽  
Leydig Cell ◽  
Heme Oxygenase 1 ◽  
Response To Stress

scholarly journals Modulation of Inflammation and Immune Responses by Heme Oxygenase-1: Implications for Infection with Intracellular Pathogens

Antioxidants ◽  
2020 ◽  
Vol 9 (12) ◽  
pp. 1205
Author(s):  
Diego L. Costa ◽  
Eduardo P. Amaral ◽  
Bruno B. Andrade ◽  
Alan Sher
Keyword(s):  
Immune Responses ◽  
Heme Oxygenase ◽  
Host Cells ◽  
In Vivo Studies ◽  
Heme Oxygenase 1 ◽  
Intracellular Pathogens ◽  
Pathogen Control ◽  
Response To Stress ◽  
Stress Signals

Heme oxygenase-1 (HO-1) catalyzes the degradation of heme molecules releasing equimolar amounts of biliverdin, iron and carbon monoxide. Its expression is induced in response to stress signals such as reactive oxygen species and inflammatory mediators with antioxidant, anti-inflammatory and immunosuppressive consequences for the host. Interestingly, several intracellular pathogens responsible for major human diseases have been shown to be powerful inducers of HO-1 expression in both host cells and in vivo. Studies have shown that this HO-1 response can be either host detrimental by impairing pathogen control or host beneficial by limiting infection induced inflammation and tissue pathology. These properties make HO-1 an attractive target for host-directed therapy (HDT) of the diseases in question, many of which have been difficult to control using conventional antibiotic approaches. Here we review the mechanisms by which HO-1 expression is induced and how the enzyme regulates inflammatory and immune responses during infection with a number of different intracellular bacterial and protozoan pathogens highlighting mechanistic commonalities and differences with the goal of identifying targets for disease intervention.

Induction of HEME Oxygenase 1 reduces inflammation and fibrosis in a mouse model of chronic hepatitis

2011 ◽  
Vol 49 (01) ◽  
Author(s):  
R Barikbin ◽  
D Schwinge ◽  
C Schramm ◽  
G Tiegs ◽  
G Sass
Keyword(s):  
Chronic Hepatitis ◽  
Mouse Model ◽  
Heme Oxygenase ◽  
Heme Oxygenase 1
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